Effects of chronic guanosine treatment on hippocampal damage and cognitive impairment of rats submitted to chronic cerebral hypoperfusion

Chronic cerebral hypoperfusion contributes to a cognitive decline related to brain disorders. Its experimental model in rats is a permanent bilateral common carotid artery occlusion (2VO). Overstimulation of the glutamatergic system excitotoxicity due to brain energetic disturbance in 2VO animals se...

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Veröffentlicht in:	Neurological sciences 2012-10, Vol.33 (5), p.985-997
Hauptverfasser:	Ganzella, Marcelo, de Oliveira, Enderson Dias Alves, Comassetto, Daniel Diniz, Cechetti, Fernanda, Cereser, Victor Hermes, Moreira, Júlia Dubois, Hansel, Gisele, Almeida, Roberto Farina, Ramos, Denise Barbosa, Figueredo, Yanier Nuñes, Souza, Debora Guerini, Oses, Jean Pierre, Worm, Paulo Valdeci, Achaval, Matilde, Netto, Carlos Alexandre, Souza, Diogo Onofre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagonism Astrocytes Brain Ischemia - drug therapy Brain Ischemia - metabolism Brain Ischemia - pathology Brain-derived neurotrophic factor Carotid artery Cerebral blood flow Cerebrospinal fluid Chromatography, High Pressure Liquid Cognition - drug effects Cognition Disorders - drug therapy Cognition Disorders - metabolism Cognition Disorders - pathology Cognitive ability Excitotoxicity Glutamatergic transmission Guanosine Guanosine - pharmacology Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Immunohistochemistry Ischemia Male Maze Learning - drug effects Medicine Medicine & Public Health Neurology Neuronal-glial interactions Neuroprotection Neuroprotective Agents - pharmacology Neuroradiology Neurosciences Neurosurgery nucleosides Original Article Plasma levels Psychiatry purines Purines - blood Purines - cerebrospinal fluid Pyramidal cells Rats Rats, Wistar S100 beta protein
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