Genetic variant of the G-CSF receptor gene is associated with lower mobilization potential and slower recovery of granulocytes after transplantation of autologous peripheral blood progenitor cells
► CSF3R gene polymorphism rs3917924 was investigated in autologous PBPCT recipients. ► Mobilization yield and pace of hematological recovery were studied. ► Lack of CSF3R variant (T allele) was associated with better mobilization potential. ► Slower recovery of granulocytes characterized patients wi...
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| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2012-11, Vol.60 (2), p.463-467 |
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| creator | Bogunia-Kubik, Katarzyna Gieryng, Anna Gebura, Katarzyna Lange, Andrzej |
| description | ► CSF3R gene polymorphism rs3917924 was investigated in autologous PBPCT recipients. ► Mobilization yield and pace of hematological recovery were studied. ► Lack of CSF3R variant (T allele) was associated with better mobilization potential. ► Slower recovery of granulocytes characterized patients with CSF3R-T allele.
Peripheral blood mobilized by cytokines (i.e. granulocyte colony stimulating factor, G-CSF) and chemotherapy has become a major source of hematopoietic stem and progenitor cells for transplantation (PBPCT). In this study the effect of the G-CSF receptor (CSF3R) gene polymorphism was investigated. The presence of the CSF3R variant (T allele, rs3917924) was related to CD34+ mobilization yield and the pace of granulocyte recovery after autologous PBPCT. The mobilization yield was higher in patients lacking the CSF3R variant (OR=4.756, p=0.046) and those with multiple myeloma (OR=10.534, p=0.019). The pace of granulocyte recovery was found to be associated with the CSF3R polymorphism and was significantly slower in patients carrying the CSF3R-T variant than in CC homozygotes (median of 17 vs. 13days, p |
| doi_str_mv | 10.1016/j.cyto.2012.06.021 |
| format | Article |
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Peripheral blood mobilized by cytokines (i.e. granulocyte colony stimulating factor, G-CSF) and chemotherapy has become a major source of hematopoietic stem and progenitor cells for transplantation (PBPCT). In this study the effect of the G-CSF receptor (CSF3R) gene polymorphism was investigated. The presence of the CSF3R variant (T allele, rs3917924) was related to CD34+ mobilization yield and the pace of granulocyte recovery after autologous PBPCT. The mobilization yield was higher in patients lacking the CSF3R variant (OR=4.756, p=0.046) and those with multiple myeloma (OR=10.534, p=0.019). The pace of granulocyte recovery was found to be associated with the CSF3R polymorphism and was significantly slower in patients carrying the CSF3R-T variant than in CC homozygotes (median of 17 vs. 13days, p<0.001). This association was confirmed (OR=4.445, p=0.014) by multiple regression analysis considering patient age and sex, the number of transplanted CD34+ cells, diagnosis and CSF3R polymorphism. These results imply that CSF3R gene polymorphism plays a significant role in PBPCT.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2012.06.021</identifier><identifier>PMID: 22796466</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Age ; Aged ; Alleles ; Antigens, CD34 - metabolism ; autografting ; Autografts ; CD34 antigen ; Cell Count ; Chemotherapy ; Colonies ; colony-stimulating factors ; CSF3R gene polymorphism ; Cytokines ; Female ; G-CSF ; Gene polymorphism ; Genetic Association Studies ; genetic polymorphism ; Genotype ; Granulocyte colony-stimulating factor ; granulocytes ; Granulocytes - metabolism ; Hematological recovery ; Hematopoietic Stem Cell Mobilization ; Hemopoiesis ; homozygosity ; Homozygotes ; Humans ; Leukocytes (granulocytic) ; Male ; Middle Aged ; Mobilization ; Multiple myeloma ; Multiple regression analysis ; myeloma ; patients ; PBPCT ; Peripheral blood ; Peripheral Blood Stem Cell Transplantation ; Polymorphism, Single Nucleotide - genetics ; Receptors, Colony-Stimulating Factor - genetics ; Regression Analysis ; Sex ; Stem cells ; Transplantation, Autologous ; Young Adult</subject><ispartof>Cytokine (Philadelphia, Pa.), 2012-11, Vol.60 (2), p.463-467</ispartof><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-a7ee977cf5b0479e0965a994cda114232bfac2ad008a086ca683bce7c7050c473</citedby><cites>FETCH-LOGICAL-c413t-a7ee977cf5b0479e0965a994cda114232bfac2ad008a086ca683bce7c7050c473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1043466612002670$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22796466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bogunia-Kubik, Katarzyna</creatorcontrib><creatorcontrib>Gieryng, Anna</creatorcontrib><creatorcontrib>Gebura, Katarzyna</creatorcontrib><creatorcontrib>Lange, Andrzej</creatorcontrib><title>Genetic variant of the G-CSF receptor gene is associated with lower mobilization potential and slower recovery of granulocytes after transplantation of autologous peripheral blood progenitor cells</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>► CSF3R gene polymorphism rs3917924 was investigated in autologous PBPCT recipients. ► Mobilization yield and pace of hematological recovery were studied. ► Lack of CSF3R variant (T allele) was associated with better mobilization potential. ► Slower recovery of granulocytes characterized patients with CSF3R-T allele.
Peripheral blood mobilized by cytokines (i.e. granulocyte colony stimulating factor, G-CSF) and chemotherapy has become a major source of hematopoietic stem and progenitor cells for transplantation (PBPCT). In this study the effect of the G-CSF receptor (CSF3R) gene polymorphism was investigated. The presence of the CSF3R variant (T allele, rs3917924) was related to CD34+ mobilization yield and the pace of granulocyte recovery after autologous PBPCT. The mobilization yield was higher in patients lacking the CSF3R variant (OR=4.756, p=0.046) and those with multiple myeloma (OR=10.534, p=0.019). The pace of granulocyte recovery was found to be associated with the CSF3R polymorphism and was significantly slower in patients carrying the CSF3R-T variant than in CC homozygotes (median of 17 vs. 13days, p<0.001). This association was confirmed (OR=4.445, p=0.014) by multiple regression analysis considering patient age and sex, the number of transplanted CD34+ cells, diagnosis and CSF3R polymorphism. These results imply that CSF3R gene polymorphism plays a significant role in PBPCT.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Alleles</subject><subject>Antigens, CD34 - metabolism</subject><subject>autografting</subject><subject>Autografts</subject><subject>CD34 antigen</subject><subject>Cell Count</subject><subject>Chemotherapy</subject><subject>Colonies</subject><subject>colony-stimulating factors</subject><subject>CSF3R gene polymorphism</subject><subject>Cytokines</subject><subject>Female</subject><subject>G-CSF</subject><subject>Gene polymorphism</subject><subject>Genetic Association Studies</subject><subject>genetic polymorphism</subject><subject>Genotype</subject><subject>Granulocyte colony-stimulating factor</subject><subject>granulocytes</subject><subject>Granulocytes - metabolism</subject><subject>Hematological recovery</subject><subject>Hematopoietic Stem Cell Mobilization</subject><subject>Hemopoiesis</subject><subject>homozygosity</subject><subject>Homozygotes</subject><subject>Humans</subject><subject>Leukocytes (granulocytic)</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mobilization</subject><subject>Multiple myeloma</subject><subject>Multiple regression analysis</subject><subject>myeloma</subject><subject>patients</subject><subject>PBPCT</subject><subject>Peripheral blood</subject><subject>Peripheral Blood Stem Cell Transplantation</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Receptors, Colony-Stimulating Factor - genetics</subject><subject>Regression Analysis</subject><subject>Sex</subject><subject>Stem cells</subject><subject>Transplantation, Autologous</subject><subject>Young Adult</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAURSMEoqXwAyzASzYZbCexE4kNGrVTpEosStfWi_My41EmDrZnqun38WG8KIUlrGzZx8dXvs6y94KvBBfq835lz8mvJBdyxdWKS_EiuxS8UTnnsng5z8siL5VSF9mbGPec86bQ-nV2IaVuFG1cZr82OGJylp0gOBgT8z1LO2SbfH1_wwJanJIPbEsUc5FBjN46SNixR5d2bPCPGNjBt25wT5CcH9nkE47JwcBg7FhcCBL5E4bzrN8GGI-Dp-xIwj7RdqKlOA10_-IgCo7JD37rj5FNGNy0w0DKdvC-Y1PwFMjNwSwOQ3ybvephiPjuebzKHm6uf6xv87vvm2_rr3e5LUWRctCIjda2r1pe6gbppSpomtJ2IEQpC9n2YCV0nNfAa2VB1UVrUVvNK25LXVxlnxYvBfh5xJjMwcU5AYxIQY0QopBS1kr8H-W1qHXBy5JQuaA2-BgD9mYK7gDhTJCZizZ7Mxdt5qINV4aKpkMfnv3H9oDd3yN_miXg4wL04A1sg4vm4Z4MFf2CuhJFRcSXhUB6spPDYKJ1OFrsHNWVTOfdvxL8BtuXyJc</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Bogunia-Kubik, Katarzyna</creator><creator>Gieryng, Anna</creator><creator>Gebura, Katarzyna</creator><creator>Lange, Andrzej</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20121101</creationdate><title>Genetic variant of the G-CSF receptor gene is associated with lower mobilization potential and slower recovery of granulocytes after transplantation of autologous peripheral blood progenitor cells</title><author>Bogunia-Kubik, Katarzyna ; Gieryng, Anna ; Gebura, Katarzyna ; Lange, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-a7ee977cf5b0479e0965a994cda114232bfac2ad008a086ca683bce7c7050c473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Alleles</topic><topic>Antigens, CD34 - metabolism</topic><topic>autografting</topic><topic>Autografts</topic><topic>CD34 antigen</topic><topic>Cell Count</topic><topic>Chemotherapy</topic><topic>Colonies</topic><topic>colony-stimulating factors</topic><topic>CSF3R gene polymorphism</topic><topic>Cytokines</topic><topic>Female</topic><topic>G-CSF</topic><topic>Gene polymorphism</topic><topic>Genetic Association Studies</topic><topic>genetic polymorphism</topic><topic>Genotype</topic><topic>Granulocyte colony-stimulating factor</topic><topic>granulocytes</topic><topic>Granulocytes - metabolism</topic><topic>Hematological recovery</topic><topic>Hematopoietic Stem Cell Mobilization</topic><topic>Hemopoiesis</topic><topic>homozygosity</topic><topic>Homozygotes</topic><topic>Humans</topic><topic>Leukocytes (granulocytic)</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mobilization</topic><topic>Multiple myeloma</topic><topic>Multiple regression analysis</topic><topic>myeloma</topic><topic>patients</topic><topic>PBPCT</topic><topic>Peripheral blood</topic><topic>Peripheral Blood Stem Cell Transplantation</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Receptors, Colony-Stimulating Factor - genetics</topic><topic>Regression Analysis</topic><topic>Sex</topic><topic>Stem cells</topic><topic>Transplantation, Autologous</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bogunia-Kubik, Katarzyna</creatorcontrib><creatorcontrib>Gieryng, Anna</creatorcontrib><creatorcontrib>Gebura, Katarzyna</creatorcontrib><creatorcontrib>Lange, Andrzej</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bogunia-Kubik, Katarzyna</au><au>Gieryng, Anna</au><au>Gebura, Katarzyna</au><au>Lange, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variant of the G-CSF receptor gene is associated with lower mobilization potential and slower recovery of granulocytes after transplantation of autologous peripheral blood progenitor cells</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>60</volume><issue>2</issue><spage>463</spage><epage>467</epage><pages>463-467</pages><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>► CSF3R gene polymorphism rs3917924 was investigated in autologous PBPCT recipients. ► Mobilization yield and pace of hematological recovery were studied. ► Lack of CSF3R variant (T allele) was associated with better mobilization potential. ► Slower recovery of granulocytes characterized patients with CSF3R-T allele.
Peripheral blood mobilized by cytokines (i.e. granulocyte colony stimulating factor, G-CSF) and chemotherapy has become a major source of hematopoietic stem and progenitor cells for transplantation (PBPCT). In this study the effect of the G-CSF receptor (CSF3R) gene polymorphism was investigated. The presence of the CSF3R variant (T allele, rs3917924) was related to CD34+ mobilization yield and the pace of granulocyte recovery after autologous PBPCT. The mobilization yield was higher in patients lacking the CSF3R variant (OR=4.756, p=0.046) and those with multiple myeloma (OR=10.534, p=0.019). The pace of granulocyte recovery was found to be associated with the CSF3R polymorphism and was significantly slower in patients carrying the CSF3R-T variant than in CC homozygotes (median of 17 vs. 13days, p<0.001). This association was confirmed (OR=4.445, p=0.014) by multiple regression analysis considering patient age and sex, the number of transplanted CD34+ cells, diagnosis and CSF3R polymorphism. These results imply that CSF3R gene polymorphism plays a significant role in PBPCT.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>22796466</pmid><doi>10.1016/j.cyto.2012.06.021</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Age Aged Alleles Antigens, CD34 - metabolism autografting Autografts CD34 antigen Cell Count Chemotherapy Colonies colony-stimulating factors CSF3R gene polymorphism Cytokines Female G-CSF Gene polymorphism Genetic Association Studies genetic polymorphism Genotype Granulocyte colony-stimulating factor granulocytes Granulocytes - metabolism Hematological recovery Hematopoietic Stem Cell Mobilization Hemopoiesis homozygosity Homozygotes Humans Leukocytes (granulocytic) Male Middle Aged Mobilization Multiple myeloma Multiple regression analysis myeloma patients PBPCT Peripheral blood Peripheral Blood Stem Cell Transplantation Polymorphism, Single Nucleotide - genetics Receptors, Colony-Stimulating Factor - genetics Regression Analysis Sex Stem cells Transplantation, Autologous Young Adult |
| title | Genetic variant of the G-CSF receptor gene is associated with lower mobilization potential and slower recovery of granulocytes after transplantation of autologous peripheral blood progenitor cells |
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