Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors

Peripheral mediators can contribute to the development and maintenance of inflammatory and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two mechanisms. Activation or excitation by these substances of nociceptive nerve endings or fibers implicates generation of action potent...

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Veröffentlicht in:	Physiological reviews 2012-10, Vol.92 (4), p.1699-1775
Hauptverfasser:	Petho, Gábor, Reeh, Peter W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Bradykinin - metabolism Eicosanoids - metabolism Humans Molecules Neurons Nitric Oxide - metabolism Nociceptors - metabolism Pain - metabolism Pain management Platelet Activating Factor - metabolism Signal transduction Signal Transduction - physiology
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