Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia

Pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) has achieved an 80% cure rate as a result of a risk-adapted therapy largely based on minimal residual disease (MRD) monitoring. However, relapse is still the most frequent adverse event, occurring mainly in the patients with intermedi...

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Veröffentlicht in:	Leukemia 2012-10, Vol.26 (10), p.2245-2253
Hauptverfasser:	Palmi, C, Vendramini, E, Silvestri, D, Longinotti, G, Frison, D, Cario, G, Shochat, C, Stanulla, M, Rossi, V, Di Meglio, A M, Villa, T, Giarin, E, Fazio, G, Leszl, A, Schrappe, M, Basso, G, Biondi, A, Izraeli, S, Conter, V, Valsecchi, M G, Cazzaniga, G, te Kronnie, G
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2422 692/699/67/1990/283 692/699/67/2332 Acute lymphoblastic leukemia Acute lymphocytic leukemia BCR-ABL protein Biological and medical sciences Cancer Research Cellular signal transduction Chromosomes Critical Care Medicine Cytokines Down syndrome Down's syndrome Fusion protein Gene expression Gene Fusion Genetic aspects Hematologic and hematopoietic diseases Hematology Humans Impact analysis Intensive Internal Medicine Leukemia Leukemia in children Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphoblastic leukemia in children Lymphocytes B Lymphocytic leukemia in children Medical prognosis Medical sciences Medicine Medicine & Public Health Minimal residual disease Mutation Oncology original-article Overexpression Patients Pediatrics Physiological aspects Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursors Prognosis Proportional Hazards Models Receptors, Cytokine - genetics Receptors, Cytokine - physiology Receptors, Purinergic P2 - genetics Recurrence Risk Risk Factors Risk groups
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