ZNF804A rs1344706 variant and schizophrenia in a Romanian population from Cluj Napoca
The ZNF804A rs1344706 variant was the first risk factor to be identified through genome-wide association studies and follow-up studies with meta-analysis for schizophrenia as well as bipolar disorders; we investigated 231 schizophrenia and 222 controls to see whether this particular variant was asso...
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| Veröffentlicht in: | Genetic testing and molecular biomarkers 2012-09, Vol.16 (9), p.1135-1137 |
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| container_title | Genetic testing and molecular biomarkers |
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| creator | Zaharie, Andreea Ergul, Emel Ozel, Mavi Deniz Miclutia, Ioana Valentina Stanculete, Mihaela Fadgyas Sazci, Ali |
| description | The ZNF804A rs1344706 variant was the first risk factor to be identified through genome-wide association studies and follow-up studies with meta-analysis for schizophrenia as well as bipolar disorders; we investigated 231 schizophrenia and 222 controls to see whether this particular variant was associated with schizophrenia in a Romanian population from Cluj Napoca. Clearly, there was no association between the ZNF804A rs1344706 variant and schizophrenia. Our study provides evidence for those that found no association with schizophrenia. A surprising result of our study was that the T allele frequency is the highest, thus far among the ethnic groups studied. We used a PCR-RFLP method that had been recently developed in our laboratory to the genotype ZNF804A rs1344706 variant. In conclusion, the ZNF804A rs1344706 variant was not associated with schizophrenia in the Romanian population from Cluj Napoca (χ(2)=0.734, p=0.693). |
| doi_str_mv | 10.1089/gtmb.2012.0066 |
| format | Article |
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we investigated 231 schizophrenia and 222 controls to see whether this particular variant was associated with schizophrenia in a Romanian population from Cluj Napoca. Clearly, there was no association between the ZNF804A rs1344706 variant and schizophrenia. Our study provides evidence for those that found no association with schizophrenia. A surprising result of our study was that the T allele frequency is the highest, thus far among the ethnic groups studied. We used a PCR-RFLP method that had been recently developed in our laboratory to the genotype ZNF804A rs1344706 variant. In conclusion, the ZNF804A rs1344706 variant was not associated with schizophrenia in the Romanian population from Cluj Napoca (χ(2)=0.734, p=0.693).</abstract><cop>United States</cop><pmid>22775511</pmid><doi>10.1089/gtmb.2012.0066</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Bipolar disorder Ethnic groups Female Gene Frequency Genetic Predisposition to Disease Genetic screening Genetic Variation Genome-Wide Association Study Genotype Genotypes Humans Kruppel-Like Transcription Factors - genetics Male Mental disorders Middle Aged Polymerase chain reaction Polymorphism, Single Nucleotide - genetics Restriction fragment length polymorphism Reviews Risk factors Romania Schizophrenia Schizophrenia - genetics Young Adult |
| title | ZNF804A rs1344706 variant and schizophrenia in a Romanian population from Cluj Napoca |
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