TET2 is essential for survival and hematopoietic stem cell homeostasis
Ten-Eleven-Translocation 2 (TET2) is an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state of DNA; somatic loss-of-function mutations of TET2 are frequently observed in patients with diverse myeloid malignancies. To s...
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| creator | Shide, K Kameda, T Shimoda, H Yamaji, T Abe, H Kamiunten, A Sekine, M Hidaka, T Katayose, K Kubuki, Y Yamamoto, S Miike, T Iwakiri, H Hasuike, S Nagata, K Marutsuka, K Iwama, A Matsuda, T Kitanaka, A Shimoda, K |
| description | Ten-Eleven-Translocation 2 (TET2) is an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state of DNA; somatic loss-of-function mutations of
TET2
are frequently observed in patients with diverse myeloid malignancies. To study the function of
TET2 in vivo
, we analyzed Ayu17-449 (
TET2
trap
) mice, in which a gene trap insertion in intron 2 of
TET2
reduces
TET2
mRNA levels to about 20% of that found in wild-type (WT) mice.
TET2
trap/trap
mice were born at Mendelian frequency but died at a high rate by postnatal day 3, indicating the essential role of TET2 for survival. Loss of TET2 results in an increase in the number of hematopoietic stem cells (HSCs)/progenitors in the fetal liver, and
TET2
trap/trap
HSCs exhibit an increased self-renewal ability
in vivo
. In competitive transplantation assays,
TET2
trap/trap
HSCs possess a competitive growth advantage over WT HSCs. These data indicate that TET2 has a critical role in survival and HSC homeostasis. |
| doi_str_mv | 10.1038/leu.2012.94 |
| format | Article |
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TET2
are frequently observed in patients with diverse myeloid malignancies. To study the function of
TET2 in vivo
, we analyzed Ayu17-449 (
TET2
trap
) mice, in which a gene trap insertion in intron 2 of
TET2
reduces
TET2
mRNA levels to about 20% of that found in wild-type (WT) mice.
TET2
trap/trap
mice were born at Mendelian frequency but died at a high rate by postnatal day 3, indicating the essential role of TET2 for survival. Loss of TET2 results in an increase in the number of hematopoietic stem cells (HSCs)/progenitors in the fetal liver, and
TET2
trap/trap
HSCs exhibit an increased self-renewal ability
in vivo
. In competitive transplantation assays,
TET2
trap/trap
HSCs possess a competitive growth advantage over WT HSCs. These data indicate that TET2 has a critical role in survival and HSC homeostasis.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/leu.2012.94</identifier><identifier>PMID: 22469782</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/443/319/1557 ; 631/67/68 ; 692/699/67/1990/2331 ; Animal experimentation ; Animals ; Biological and medical sciences ; Cancer Research ; Cell self-renewal ; Cell Survival ; Critical Care Medicine ; Deoxyribonucleic acid ; DNA ; DNA-Binding Proteins - physiology ; Epigenetics ; Fetuses ; Gastroenterology ; Gene mutations ; Genetic aspects ; Granulocytes ; Hematologic and hematopoietic diseases ; Hematology ; Hematopoiesis ; Hematopoietic stem cells ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - physiology ; Homeostasis ; In vivo methods and tests ; Intensive ; Internal Medicine ; Janus Kinase 2 - physiology ; Kinases ; Leukemia ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Medicine ; Medicine & Public Health ; Mice ; Mice, Inbred C57BL ; mRNA ; Mutation ; Oncology ; original-article ; Physiological aspects ; Progenitor cells ; Proto-Oncogene Proteins - physiology ; RNA, Messenger - analysis ; Stem cell transplantation ; Stem cells ; Survival ; Translocation ; Transplantation ; Tumors</subject><ispartof>Leukemia, 2012-10, Vol.26 (10), p.2216-2223</ispartof><rights>Macmillan Publishers Limited 2012</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2012</rights><rights>Macmillan Publishers Limited 2012.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-5bae8740250aa9be58ff9da34613d7f1f9b34d10c9638d06984458d97169f2e23</citedby><cites>FETCH-LOGICAL-c580t-5bae8740250aa9be58ff9da34613d7f1f9b34d10c9638d06984458d97169f2e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2012.94$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2012.94$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26442719$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22469782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shide, K</creatorcontrib><creatorcontrib>Kameda, T</creatorcontrib><creatorcontrib>Shimoda, H</creatorcontrib><creatorcontrib>Yamaji, T</creatorcontrib><creatorcontrib>Abe, H</creatorcontrib><creatorcontrib>Kamiunten, A</creatorcontrib><creatorcontrib>Sekine, M</creatorcontrib><creatorcontrib>Hidaka, T</creatorcontrib><creatorcontrib>Katayose, K</creatorcontrib><creatorcontrib>Kubuki, Y</creatorcontrib><creatorcontrib>Yamamoto, S</creatorcontrib><creatorcontrib>Miike, T</creatorcontrib><creatorcontrib>Iwakiri, H</creatorcontrib><creatorcontrib>Hasuike, S</creatorcontrib><creatorcontrib>Nagata, K</creatorcontrib><creatorcontrib>Marutsuka, K</creatorcontrib><creatorcontrib>Iwama, A</creatorcontrib><creatorcontrib>Matsuda, T</creatorcontrib><creatorcontrib>Kitanaka, A</creatorcontrib><creatorcontrib>Shimoda, K</creatorcontrib><title>TET2 is essential for survival and hematopoietic stem cell homeostasis</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>Ten-Eleven-Translocation 2 (TET2) is an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state of DNA; somatic loss-of-function mutations of
TET2
are frequently observed in patients with diverse myeloid malignancies. To study the function of
TET2 in vivo
, we analyzed Ayu17-449 (
TET2
trap
) mice, in which a gene trap insertion in intron 2 of
TET2
reduces
TET2
mRNA levels to about 20% of that found in wild-type (WT) mice.
TET2
trap/trap
mice were born at Mendelian frequency but died at a high rate by postnatal day 3, indicating the essential role of TET2 for survival. Loss of TET2 results in an increase in the number of hematopoietic stem cells (HSCs)/progenitors in the fetal liver, and
TET2
trap/trap
HSCs exhibit an increased self-renewal ability
in vivo
. In competitive transplantation assays,
TET2
trap/trap
HSCs possess a competitive growth advantage over WT HSCs. These data indicate that TET2 has a critical role in survival and HSC homeostasis.</description><subject>631/443/319/1557</subject><subject>631/67/68</subject><subject>692/699/67/1990/2331</subject><subject>Animal experimentation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cancer Research</subject><subject>Cell self-renewal</subject><subject>Cell Survival</subject><subject>Critical Care Medicine</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Epigenetics</subject><subject>Fetuses</subject><subject>Gastroenterology</subject><subject>Gene mutations</subject><subject>Genetic aspects</subject><subject>Granulocytes</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Hematopoiesis</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Homeostasis</subject><subject>In vivo methods and tests</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Janus Kinase 2 - physiology</subject><subject>Kinases</subject><subject>Leukemia</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>mRNA</subject><subject>Mutation</subject><subject>Oncology</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Progenitor cells</subject><subject>Proto-Oncogene Proteins - physiology</subject><subject>RNA, Messenger - analysis</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Survival</subject><subject>Translocation</subject><subject>Transplantation</subject><subject>Tumors</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkt9rFDEQxxdR7LX65LssiCLonfm9yWMprQoFX87nkNud9FJ2N2cmW_C_N8td9aqi5CFk5jPfmQnfqnpByYoSrj_0MK0YoWxlxKNqQUWjllJK-rhaEK2bpTJMnFSniLeEzEn1tDphTCjTaLaortaXa1YHrAERxhxcX_uYapzSXbgrDzd29RYGl-MuBsihrTHDULfQ9_U2DhAxOwz4rHriXY_w_HCfVV-vLtcXn5bXXz5-vji_XrZSk7yUGwe6EYRJ4pzZgNTem85xoSjvGk-92XDRUdIaxXVHlNFCSN2ZhirjGTB-Vr3d6-5S_DYBZjsEnIdxI8QJLaWUM2oaIv-PEiM15bxRBX31G3obpzSWRSxTQjZlPsH-Rc1awghjjrRuXA82jD7m5Nq5tT3nRDFBGmoKtfoLVU4HQ2jjCD6U-IOCN0cFW3B93mLspxziiA_Bd3uwTRExgbe7FAaXvpch7ewXW_xiZ79YIwr98rDTtBmg-8neG6QArw-Aw9b1PrmxDfiLU0Kwfdv3ew5LaryBdPw5f_b9AZD90PI</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Shide, K</creator><creator>Kameda, T</creator><creator>Shimoda, H</creator><creator>Yamaji, T</creator><creator>Abe, H</creator><creator>Kamiunten, A</creator><creator>Sekine, M</creator><creator>Hidaka, T</creator><creator>Katayose, K</creator><creator>Kubuki, Y</creator><creator>Yamamoto, S</creator><creator>Miike, T</creator><creator>Iwakiri, H</creator><creator>Hasuike, S</creator><creator>Nagata, K</creator><creator>Marutsuka, K</creator><creator>Iwama, A</creator><creator>Matsuda, T</creator><creator>Kitanaka, A</creator><creator>Shimoda, K</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>TET2 is essential for survival and hematopoietic stem cell homeostasis</title><author>Shide, K ; Kameda, T ; Shimoda, H ; Yamaji, T ; Abe, H ; Kamiunten, A ; Sekine, M ; Hidaka, T ; Katayose, K ; Kubuki, Y ; Yamamoto, S ; Miike, T ; Iwakiri, H ; Hasuike, S ; Nagata, K ; Marutsuka, K ; Iwama, A ; Matsuda, T ; Kitanaka, A ; Shimoda, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-5bae8740250aa9be58ff9da34613d7f1f9b34d10c9638d06984458d97169f2e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>631/443/319/1557</topic><topic>631/67/68</topic><topic>692/699/67/1990/2331</topic><topic>Animal experimentation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cancer Research</topic><topic>Cell self-renewal</topic><topic>Cell Survival</topic><topic>Critical Care Medicine</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Epigenetics</topic><topic>Fetuses</topic><topic>Gastroenterology</topic><topic>Gene mutations</topic><topic>Genetic aspects</topic><topic>Granulocytes</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Hematopoiesis</topic><topic>Hematopoietic stem cells</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Homeostasis</topic><topic>In vivo methods and tests</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Janus Kinase 2 - physiology</topic><topic>Kinases</topic><topic>Leukemia</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>mRNA</topic><topic>Mutation</topic><topic>Oncology</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Progenitor cells</topic><topic>Proto-Oncogene Proteins - physiology</topic><topic>RNA, Messenger - analysis</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Survival</topic><topic>Translocation</topic><topic>Transplantation</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shide, K</creatorcontrib><creatorcontrib>Kameda, T</creatorcontrib><creatorcontrib>Shimoda, H</creatorcontrib><creatorcontrib>Yamaji, T</creatorcontrib><creatorcontrib>Abe, H</creatorcontrib><creatorcontrib>Kamiunten, A</creatorcontrib><creatorcontrib>Sekine, M</creatorcontrib><creatorcontrib>Hidaka, T</creatorcontrib><creatorcontrib>Katayose, K</creatorcontrib><creatorcontrib>Kubuki, Y</creatorcontrib><creatorcontrib>Yamamoto, S</creatorcontrib><creatorcontrib>Miike, T</creatorcontrib><creatorcontrib>Iwakiri, H</creatorcontrib><creatorcontrib>Hasuike, S</creatorcontrib><creatorcontrib>Nagata, K</creatorcontrib><creatorcontrib>Marutsuka, K</creatorcontrib><creatorcontrib>Iwama, A</creatorcontrib><creatorcontrib>Matsuda, T</creatorcontrib><creatorcontrib>Kitanaka, A</creatorcontrib><creatorcontrib>Shimoda, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shide, K</au><au>Kameda, T</au><au>Shimoda, H</au><au>Yamaji, T</au><au>Abe, H</au><au>Kamiunten, A</au><au>Sekine, M</au><au>Hidaka, T</au><au>Katayose, K</au><au>Kubuki, Y</au><au>Yamamoto, S</au><au>Miike, T</au><au>Iwakiri, H</au><au>Hasuike, S</au><au>Nagata, K</au><au>Marutsuka, K</au><au>Iwama, A</au><au>Matsuda, T</au><au>Kitanaka, A</au><au>Shimoda, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TET2 is essential for survival and hematopoietic stem cell homeostasis</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>26</volume><issue>10</issue><spage>2216</spage><epage>2223</epage><pages>2216-2223</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>Ten-Eleven-Translocation 2 (TET2) is an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state of DNA; somatic loss-of-function mutations of
TET2
are frequently observed in patients with diverse myeloid malignancies. To study the function of
TET2 in vivo
, we analyzed Ayu17-449 (
TET2
trap
) mice, in which a gene trap insertion in intron 2 of
TET2
reduces
TET2
mRNA levels to about 20% of that found in wild-type (WT) mice.
TET2
trap/trap
mice were born at Mendelian frequency but died at a high rate by postnatal day 3, indicating the essential role of TET2 for survival. Loss of TET2 results in an increase in the number of hematopoietic stem cells (HSCs)/progenitors in the fetal liver, and
TET2
trap/trap
HSCs exhibit an increased self-renewal ability
in vivo
. In competitive transplantation assays,
TET2
trap/trap
HSCs possess a competitive growth advantage over WT HSCs. These data indicate that TET2 has a critical role in survival and HSC homeostasis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22469782</pmid><doi>10.1038/leu.2012.94</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-6924 |
| ispartof | Leukemia, 2012-10, Vol.26 (10), p.2216-2223 |
| issn | 0887-6924 1476-5551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1113219705 |
| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals |
| subjects | 631/443/319/1557 631/67/68 692/699/67/1990/2331 Animal experimentation Animals Biological and medical sciences Cancer Research Cell self-renewal Cell Survival Critical Care Medicine Deoxyribonucleic acid DNA DNA-Binding Proteins - physiology Epigenetics Fetuses Gastroenterology Gene mutations Genetic aspects Granulocytes Hematologic and hematopoietic diseases Hematology Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Homeostasis In vivo methods and tests Intensive Internal Medicine Janus Kinase 2 - physiology Kinases Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred C57BL mRNA Mutation Oncology original-article Physiological aspects Progenitor cells Proto-Oncogene Proteins - physiology RNA, Messenger - analysis Stem cell transplantation Stem cells Survival Translocation Transplantation Tumors |
| title | TET2 is essential for survival and hematopoietic stem cell homeostasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T14%3A08%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TET2%20is%20essential%20for%20survival%20and%20hematopoietic%20stem%20cell%20homeostasis&rft.jtitle=Leukemia&rft.au=Shide,%20K&rft.date=2012-10-01&rft.volume=26&rft.issue=10&rft.spage=2216&rft.epage=2223&rft.pages=2216-2223&rft.issn=0887-6924&rft.eissn=1476-5551&rft.coden=LEUKED&rft_id=info:doi/10.1038/leu.2012.94&rft_dat=%3Cgale_proqu%3EA306240719%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1095494996&rft_id=info:pmid/22469782&rft_galeid=A306240719&rfr_iscdi=true |