Requirements for human Dicer and TRBP in microRNA-122 regulation of HCV translation and RNA abundance

Abstract MicroRNA-122 (miR-122) promotes Hepatitis C Virus (HCV) RNA stability, accumulation, and translation through hybridization with the 5′ untranslated region (5′ UTR) of the HCV genome. Depletion of Dicer and TRBP, proteins involved in miRNA biogenesis, reduced HCV RNA accumulation, mature dup...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2012-11, Vol.433 (2), p.479-488
Hauptverfasser:	Zhang, Chao, Huys, Adam, Thibault, Patricia A, Wilson, Joyce A
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Animals Argonaute Base Sequence Cell Line Cells, Cultured DEAD-box RNA Helicases - antagonists & inhibitors DEAD-box RNA Helicases - deficiency DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Dicer Fibroblasts Gene Knockdown Techniques Genome, Viral Genomes Hepacivirus - genetics Hepacivirus - metabolism Hepatitis C virus Host-Pathogen Interactions Humans Infectious Disease Mice Mice, Knockout Micro RNA MicroRNAs - genetics MicroRNAs - metabolism miR-122 miRNA miRNA processing Models, Biological Protein Biosynthesis Replication Ribonuclease III - antagonists & inhibitors Ribonuclease III - deficiency Ribonuclease III - genetics Ribonuclease III - metabolism RNA induced silencing complex RNA processing RNA Processing, Post-Transcriptional RNA Stability RNA viruses RNA, Small Interfering - genetics RNA, Viral - genetics RNA, Viral - metabolism RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Translation TRBP TRBP protein Virus Replication
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