Comparison of In Vivo with In Vitro Pharmacokinetics of Mercury Between Methylmercury Chloride and Methylmercury Cysteine Using Rats and Caco2 Cells
The in vivo and in vitro pharmacokinetics of mercury (Hg) were compared between methylmercury chloride (MeHg·Cl) and methylmercury cysteine (MeHg-Cys) using rats and Caco2 cells because humans can be exposed to MeHg compounds through dietary fish. The in vivo pharmacokinetics of Hg immediately after...
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| Veröffentlicht in: | Archives of environmental contamination and toxicology 2012-11, Vol.63 (4), p.628-636 |
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| creator | Mori, Nobuhiro Yamamoto, Megumi Tsukada, Eri Yokooji, Tomoharu Matsumura, Naoko Sasaki, Masanori Murakami, Teruo |
| description | The in vivo and in vitro pharmacokinetics of mercury (Hg) were compared between methylmercury chloride (MeHg·Cl) and methylmercury cysteine (MeHg-Cys) using rats and Caco2 cells because humans can be exposed to MeHg compounds through dietary fish. The in vivo pharmacokinetics of Hg immediately after the digestion of MeHg compounds are still obscure. In Caco2 cells, membrane uptake and subcellular distribution of MeHg compounds were examined. When rats received it intravenously, MeHg·Cl showed 20-fold greater plasma and 2-fold greater blood concentrations of Hg than MeHg-Cys, indicating that their pharmacokinetic properties are different. One hour later, however, Hg concentrations in plasma and blood became virtually identical between MeHg·Cl and MeHg-Cys, although blood Hg concentrations were >100-fold greater than those in plasma. When administered into the closed rat’s jejunum loop, MeHg·Cl and MeHg-Cys were rapidly and efficiently taken up by intestinal membranes, and Hg was retained in intestinal membranes for a relatively long time. When administered orally, no difference was observed in plasma and blood Hg concentrations between MeHg·Cl and MeHg-Cys: plasma and blood Hg concentrations increased gradually and reached steady levels at 8 h after administration. In Caco2 cells, uptake of MeHg-Cys was significantly suppressed by
l
-leucine, although this was not seen with MeHg·Cl. In Caco2 cells, 81 % of Hg was recovered from cytosol fractions and 13 % of Hg from nuclear fractions (including debris) after a 2-h incubation with MeHg-Cys. In conclusion, the mechanism of membrane uptake and volume of distribution in the initial distribution phase were clearly different between MeHg·Cl and MeHg-Cys. However, such pharmacokinetic differences between them disappeared 1 h after intravenous and after oral routes of administration, possibly due to the metabolism in the body. |
| doi_str_mv | 10.1007/s00244-012-9800-5 |
| format | Article |
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l
-leucine, although this was not seen with MeHg·Cl. In Caco2 cells, 81 % of Hg was recovered from cytosol fractions and 13 % of Hg from nuclear fractions (including debris) after a 2-h incubation with MeHg-Cys. In conclusion, the mechanism of membrane uptake and volume of distribution in the initial distribution phase were clearly different between MeHg·Cl and MeHg-Cys. However, such pharmacokinetic differences between them disappeared 1 h after intravenous and after oral routes of administration, possibly due to the metabolism in the body.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/s00244-012-9800-5</identifier><identifier>PMID: 22932937</identifier><identifier>CODEN: AECTCV</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Administration, Intravenous ; Administration, Oral ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biocompatibility ; Biological and medical sciences ; Biomedical materials ; Blood ; Body temperature ; Caco-2 Cells ; Comparative analysis ; Cysteine - analogs & derivatives ; Cysteine - blood ; Cysteine - pharmacokinetics ; Earth and Environmental Science ; Ecotoxicology ; Ecotoxicology, biological effects of pollution ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental monitoring ; Experiments ; Fishes ; Fundamental and applied biological sciences. Psychology ; General aspects ; Humans ; In vivo testing ; In vivo tests ; Laboratory animals ; Leucine - pharmacology ; Male ; Membranes ; Mercury ; Mercury - blood ; Mercury - pharmacokinetics ; Methylmercury ; Methylmercury Compounds - blood ; Methylmercury Compounds - pharmacokinetics ; Monitoring/Environmental Analysis ; Pharmacokinetics ; Physiology ; Plasma ; Pollution ; Rats ; Rats, Sprague-Dawley ; Small intestine ; Soil Science & Conservation ; Studies ; Surgical implants ; Tissue Distribution</subject><ispartof>Archives of environmental contamination and toxicology, 2012-11, Vol.63 (4), p.628-636</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><rights>2015 INIST-CNRS</rights><rights>Springer Science+Business Media New York 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-9bc207863e7bdd2fd2814f2fdbc5a4de7f0e9c15aa7d83efe9c3a85a2f46fc573</citedby><cites>FETCH-LOGICAL-c435t-9bc207863e7bdd2fd2814f2fdbc5a4de7f0e9c15aa7d83efe9c3a85a2f46fc573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00244-012-9800-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00244-012-9800-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26545620$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22932937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mori, Nobuhiro</creatorcontrib><creatorcontrib>Yamamoto, Megumi</creatorcontrib><creatorcontrib>Tsukada, Eri</creatorcontrib><creatorcontrib>Yokooji, Tomoharu</creatorcontrib><creatorcontrib>Matsumura, Naoko</creatorcontrib><creatorcontrib>Sasaki, Masanori</creatorcontrib><creatorcontrib>Murakami, Teruo</creatorcontrib><title>Comparison of In Vivo with In Vitro Pharmacokinetics of Mercury Between Methylmercury Chloride and Methylmercury Cysteine Using Rats and Caco2 Cells</title><title>Archives of environmental contamination and toxicology</title><addtitle>Arch Environ Contam Toxicol</addtitle><addtitle>Arch Environ Contam Toxicol</addtitle><description>The in vivo and in vitro pharmacokinetics of mercury (Hg) were compared between methylmercury chloride (MeHg·Cl) and methylmercury cysteine (MeHg-Cys) using rats and Caco2 cells because humans can be exposed to MeHg compounds through dietary fish. The in vivo pharmacokinetics of Hg immediately after the digestion of MeHg compounds are still obscure. In Caco2 cells, membrane uptake and subcellular distribution of MeHg compounds were examined. When rats received it intravenously, MeHg·Cl showed 20-fold greater plasma and 2-fold greater blood concentrations of Hg than MeHg-Cys, indicating that their pharmacokinetic properties are different. One hour later, however, Hg concentrations in plasma and blood became virtually identical between MeHg·Cl and MeHg-Cys, although blood Hg concentrations were >100-fold greater than those in plasma. When administered into the closed rat’s jejunum loop, MeHg·Cl and MeHg-Cys were rapidly and efficiently taken up by intestinal membranes, and Hg was retained in intestinal membranes for a relatively long time. When administered orally, no difference was observed in plasma and blood Hg concentrations between MeHg·Cl and MeHg-Cys: plasma and blood Hg concentrations increased gradually and reached steady levels at 8 h after administration. In Caco2 cells, uptake of MeHg-Cys was significantly suppressed by
l
-leucine, although this was not seen with MeHg·Cl. In Caco2 cells, 81 % of Hg was recovered from cytosol fractions and 13 % of Hg from nuclear fractions (including debris) after a 2-h incubation with MeHg-Cys. In conclusion, the mechanism of membrane uptake and volume of distribution in the initial distribution phase were clearly different between MeHg·Cl and MeHg-Cys. However, such pharmacokinetic differences between them disappeared 1 h after intravenous and after oral routes of administration, possibly due to the metabolism in the body.</description><subject>Administration, Intravenous</subject><subject>Administration, Oral</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biocompatibility</subject><subject>Biological and medical sciences</subject><subject>Biomedical materials</subject><subject>Blood</subject><subject>Body temperature</subject><subject>Caco-2 Cells</subject><subject>Comparative analysis</subject><subject>Cysteine - analogs & derivatives</subject><subject>Cysteine - blood</subject><subject>Cysteine - pharmacokinetics</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental monitoring</subject><subject>Experiments</subject><subject>Fishes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Humans</subject><subject>In vivo testing</subject><subject>In vivo tests</subject><subject>Laboratory animals</subject><subject>Leucine - pharmacology</subject><subject>Male</subject><subject>Membranes</subject><subject>Mercury</subject><subject>Mercury - blood</subject><subject>Mercury - pharmacokinetics</subject><subject>Methylmercury</subject><subject>Methylmercury Compounds - blood</subject><subject>Methylmercury Compounds - pharmacokinetics</subject><subject>Monitoring/Environmental Analysis</subject><subject>Pharmacokinetics</subject><subject>Physiology</subject><subject>Plasma</subject><subject>Pollution</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Small intestine</subject><subject>Soil Science & Conservation</subject><subject>Studies</subject><subject>Surgical implants</subject><subject>Tissue Distribution</subject><issn>0090-4341</issn><issn>1432-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkV1rFDEUhoModrv6A7yRgAi9Gc3nJnOpgx-FlopYb0M2k3RTZ5I1yVj2f_iDzXa2KgVBCBxOznPec5IXgGcYvcIIidcZIcJYgzBpWolQwx-ABWaUNEgg-hAsEGpRwyjDR-A452tUQSnZY3BESEvrEQvws4vjViefY4DRwdMAv_ofEd74spmTkiL8tNFp1CZ-88EWb_KePLfJTGkH39pyY22oednshvFw222GmHxvoQ79_dIuF1uF4GX24Qp-1iXfUl0dQGBnhyE_AY-cHrJ9eohLcPn-3ZfuY3N28eG0e3PWGEZ5adq1IUjIFbVi3ffE9URi5mpcG65Zb4VDtjWYay16Sa2rCdWSa-LYyhku6BKczLrbFL9PNhc1-mzqBjrYOGWFMaYEC0HJ_6BYcknq9y_Bi3vodZxSqA9RGEnMKaaMVgrPlEkx52Sd2iY_6rSrkNq7q2Z3VTVN7d1VvPY8PyhP69H2vzvu7KzAywOgs9GDSzoYn_9wK874iqDKkZnLtRSubPp7xX9N_wXYEr3A</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Mori, Nobuhiro</creator><creator>Yamamoto, Megumi</creator><creator>Tsukada, Eri</creator><creator>Yokooji, Tomoharu</creator><creator>Matsumura, Naoko</creator><creator>Sasaki, Masanori</creator><creator>Murakami, Teruo</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><scope>7SU</scope><scope>KR7</scope></search><sort><creationdate>20121101</creationdate><title>Comparison of In Vivo with In Vitro Pharmacokinetics of Mercury Between Methylmercury Chloride and Methylmercury Cysteine Using Rats and Caco2 Cells</title><author>Mori, Nobuhiro ; Yamamoto, Megumi ; Tsukada, Eri ; Yokooji, Tomoharu ; Matsumura, Naoko ; Sasaki, Masanori ; Murakami, Teruo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-9bc207863e7bdd2fd2814f2fdbc5a4de7f0e9c15aa7d83efe9c3a85a2f46fc573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Intravenous</topic><topic>Administration, Oral</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biocompatibility</topic><topic>Biological and medical sciences</topic><topic>Biomedical materials</topic><topic>Blood</topic><topic>Body temperature</topic><topic>Caco-2 Cells</topic><topic>Comparative analysis</topic><topic>Cysteine - analogs & derivatives</topic><topic>Cysteine - blood</topic><topic>Cysteine - pharmacokinetics</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental monitoring</topic><topic>Experiments</topic><topic>Fishes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Humans</topic><topic>In vivo testing</topic><topic>In vivo tests</topic><topic>Laboratory animals</topic><topic>Leucine - pharmacology</topic><topic>Male</topic><topic>Membranes</topic><topic>Mercury</topic><topic>Mercury - blood</topic><topic>Mercury - pharmacokinetics</topic><topic>Methylmercury</topic><topic>Methylmercury Compounds - blood</topic><topic>Methylmercury Compounds - pharmacokinetics</topic><topic>Monitoring/Environmental Analysis</topic><topic>Pharmacokinetics</topic><topic>Physiology</topic><topic>Plasma</topic><topic>Pollution</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Small intestine</topic><topic>Soil Science & Conservation</topic><topic>Studies</topic><topic>Surgical implants</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mori, Nobuhiro</creatorcontrib><creatorcontrib>Yamamoto, Megumi</creatorcontrib><creatorcontrib>Tsukada, Eri</creatorcontrib><creatorcontrib>Yokooji, Tomoharu</creatorcontrib><creatorcontrib>Matsumura, Naoko</creatorcontrib><creatorcontrib>Sasaki, Masanori</creatorcontrib><creatorcontrib>Murakami, Teruo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Environmental Engineering Abstracts</collection><collection>Civil Engineering Abstracts</collection><jtitle>Archives of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mori, Nobuhiro</au><au>Yamamoto, Megumi</au><au>Tsukada, Eri</au><au>Yokooji, Tomoharu</au><au>Matsumura, Naoko</au><au>Sasaki, Masanori</au><au>Murakami, Teruo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of In Vivo with In Vitro Pharmacokinetics of Mercury Between Methylmercury Chloride and Methylmercury Cysteine Using Rats and Caco2 Cells</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><stitle>Arch Environ Contam Toxicol</stitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>63</volume><issue>4</issue><spage>628</spage><epage>636</epage><pages>628-636</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><abstract>The in vivo and in vitro pharmacokinetics of mercury (Hg) were compared between methylmercury chloride (MeHg·Cl) and methylmercury cysteine (MeHg-Cys) using rats and Caco2 cells because humans can be exposed to MeHg compounds through dietary fish. The in vivo pharmacokinetics of Hg immediately after the digestion of MeHg compounds are still obscure. In Caco2 cells, membrane uptake and subcellular distribution of MeHg compounds were examined. When rats received it intravenously, MeHg·Cl showed 20-fold greater plasma and 2-fold greater blood concentrations of Hg than MeHg-Cys, indicating that their pharmacokinetic properties are different. One hour later, however, Hg concentrations in plasma and blood became virtually identical between MeHg·Cl and MeHg-Cys, although blood Hg concentrations were >100-fold greater than those in plasma. When administered into the closed rat’s jejunum loop, MeHg·Cl and MeHg-Cys were rapidly and efficiently taken up by intestinal membranes, and Hg was retained in intestinal membranes for a relatively long time. When administered orally, no difference was observed in plasma and blood Hg concentrations between MeHg·Cl and MeHg-Cys: plasma and blood Hg concentrations increased gradually and reached steady levels at 8 h after administration. In Caco2 cells, uptake of MeHg-Cys was significantly suppressed by
l
-leucine, although this was not seen with MeHg·Cl. In Caco2 cells, 81 % of Hg was recovered from cytosol fractions and 13 % of Hg from nuclear fractions (including debris) after a 2-h incubation with MeHg-Cys. In conclusion, the mechanism of membrane uptake and volume of distribution in the initial distribution phase were clearly different between MeHg·Cl and MeHg-Cys. However, such pharmacokinetic differences between them disappeared 1 h after intravenous and after oral routes of administration, possibly due to the metabolism in the body.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22932937</pmid><doi>10.1007/s00244-012-9800-5</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-4341 |
| ispartof | Archives of environmental contamination and toxicology, 2012-11, Vol.63 (4), p.628-636 |
| issn | 0090-4341 1432-0703 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1113217732 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Administration, Intravenous Administration, Oral Animal, plant and microbial ecology Animals Applied ecology Biocompatibility Biological and medical sciences Biomedical materials Blood Body temperature Caco-2 Cells Comparative analysis Cysteine - analogs & derivatives Cysteine - blood Cysteine - pharmacokinetics Earth and Environmental Science Ecotoxicology Ecotoxicology, biological effects of pollution Environment Environmental Chemistry Environmental Health Environmental monitoring Experiments Fishes Fundamental and applied biological sciences. Psychology General aspects Humans In vivo testing In vivo tests Laboratory animals Leucine - pharmacology Male Membranes Mercury Mercury - blood Mercury - pharmacokinetics Methylmercury Methylmercury Compounds - blood Methylmercury Compounds - pharmacokinetics Monitoring/Environmental Analysis Pharmacokinetics Physiology Plasma Pollution Rats Rats, Sprague-Dawley Small intestine Soil Science & Conservation Studies Surgical implants Tissue Distribution |
| title | Comparison of In Vivo with In Vitro Pharmacokinetics of Mercury Between Methylmercury Chloride and Methylmercury Cysteine Using Rats and Caco2 Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T14%3A06%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20In%20Vivo%20with%20In%20Vitro%20Pharmacokinetics%20of%20Mercury%20Between%20Methylmercury%20Chloride%20and%20Methylmercury%20Cysteine%20Using%20Rats%20and%20Caco2%20Cells&rft.jtitle=Archives%20of%20environmental%20contamination%20and%20toxicology&rft.au=Mori,%20Nobuhiro&rft.date=2012-11-01&rft.volume=63&rft.issue=4&rft.spage=628&rft.epage=636&rft.pages=628-636&rft.issn=0090-4341&rft.eissn=1432-0703&rft.coden=AECTCV&rft_id=info:doi/10.1007/s00244-012-9800-5&rft_dat=%3Cproquest_cross%3E1113217732%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1081531343&rft_id=info:pmid/22932937&rfr_iscdi=true |