Catastrophic antiphospholipid syndrome triggered by fulminant disseminated herpes simplex infection in a patient with systemic lupus erythematosus
Infections are considered one of the most common causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE), and occasionally can trigger a catastrophic antiphospholipid syndrome (APS). We describe a 22-year-old SLE patient with lupus nephritis under immunosuppressant ther...
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| Veröffentlicht in: | Lupus 2012-10, Vol.21 (12), p.1359-1361 |
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| creator | Catoggio, C Alvarez-Uría, A Fernandez, PL Cervera, R Espinosa, G |
| description | Infections are considered one of the most common causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE), and occasionally can trigger a catastrophic antiphospholipid syndrome (APS). We describe a 22-year-old SLE patient with lupus nephritis under immunosuppressant therapy and asymptomatic carrier of antiphospholipid antibodies, who was admitted with tonsillitis and acute hepatitis, developing multiorgan failure in a few hours. Postmortem examination revealed hepatic necrosis, tonsillitis, pharyngitis and uterine cervicitis caused by herpes simplex virus (HSV) together with microthrombosis in lungs and glomerular arterioles, suggesting the diagnosis of fulminant HSV disseminated infection and catastrophic APS. |
| doi_str_mv | 10.1177/0961203312458841 |
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We describe a 22-year-old SLE patient with lupus nephritis under immunosuppressant therapy and asymptomatic carrier of antiphospholipid antibodies, who was admitted with tonsillitis and acute hepatitis, developing multiorgan failure in a few hours. Postmortem examination revealed hepatic necrosis, tonsillitis, pharyngitis and uterine cervicitis caused by herpes simplex virus (HSV) together with microthrombosis in lungs and glomerular arterioles, suggesting the diagnosis of fulminant HSV disseminated infection and catastrophic APS.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203312458841</identifier><identifier>PMID: 22930205</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Abdomen ; Antibodies ; Antibodies, Antiphospholipid - immunology ; Anticoagulants ; antiphospholipid antibodies ; antiphospholipid syndrome ; Antiphospholipid Syndrome - etiology ; Antiphospholipid Syndrome - immunology ; Antiphospholipid Syndrome - physiopathology ; Arterioles ; Autoimmune diseases ; Case reports ; Catastrophic Illness ; Cervicitis ; Disseminated infection ; Endothelium ; Fatal Outcome ; Female ; Hepatitis ; Herpes simplex ; Herpes Simplex - etiology ; Herpes Simplex - physiopathology ; Herpes simplex virus ; Herpes viruses ; Humans ; Immunosuppressive agents ; Immunosuppressive Agents - therapeutic use ; Infections ; Liver ; Lung ; Lungs ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - drug therapy ; Lupus nephritis ; Lupus Nephritis - complications ; Lupus Nephritis - drug therapy ; Morbidity ; Mortality ; Multiple Organ Failure - etiology ; Necrosis ; Patients ; Pharyngitis ; Systemic lupus erythematosus ; Tonsillitis ; Uterus ; Viral infections ; Young Adult</subject><ispartof>Lupus, 2012-10, Vol.21 (12), p.1359-1361</ispartof><rights>The Author(s), 2012. Reprints and permissions: http://www.sagepub.co.uk/journalsPermissions.nav</rights><rights>SAGE Publications © Oct 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-85dd96649a848bd8c61a1d63b9965b116c31c47e98eb0fd0521fc1137302d6363</citedby><cites>FETCH-LOGICAL-c398t-85dd96649a848bd8c61a1d63b9965b116c31c47e98eb0fd0521fc1137302d6363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203312458841$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203312458841$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22930205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Catoggio, C</creatorcontrib><creatorcontrib>Alvarez-Uría, A</creatorcontrib><creatorcontrib>Fernandez, PL</creatorcontrib><creatorcontrib>Cervera, R</creatorcontrib><creatorcontrib>Espinosa, G</creatorcontrib><title>Catastrophic antiphospholipid syndrome triggered by fulminant disseminated herpes simplex infection in a patient with systemic lupus erythematosus</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Infections are considered one of the most common causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE), and occasionally can trigger a catastrophic antiphospholipid syndrome (APS). We describe a 22-year-old SLE patient with lupus nephritis under immunosuppressant therapy and asymptomatic carrier of antiphospholipid antibodies, who was admitted with tonsillitis and acute hepatitis, developing multiorgan failure in a few hours. Postmortem examination revealed hepatic necrosis, tonsillitis, pharyngitis and uterine cervicitis caused by herpes simplex virus (HSV) together with microthrombosis in lungs and glomerular arterioles, suggesting the diagnosis of fulminant HSV disseminated infection and catastrophic APS.</description><subject>Abdomen</subject><subject>Antibodies</subject><subject>Antibodies, Antiphospholipid - immunology</subject><subject>Anticoagulants</subject><subject>antiphospholipid antibodies</subject><subject>antiphospholipid syndrome</subject><subject>Antiphospholipid Syndrome - etiology</subject><subject>Antiphospholipid Syndrome - immunology</subject><subject>Antiphospholipid Syndrome - physiopathology</subject><subject>Arterioles</subject><subject>Autoimmune diseases</subject><subject>Case reports</subject><subject>Catastrophic Illness</subject><subject>Cervicitis</subject><subject>Disseminated infection</subject><subject>Endothelium</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Hepatitis</subject><subject>Herpes simplex</subject><subject>Herpes Simplex - etiology</subject><subject>Herpes Simplex - physiopathology</subject><subject>Herpes simplex virus</subject><subject>Herpes viruses</subject><subject>Humans</subject><subject>Immunosuppressive agents</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Infections</subject><subject>Liver</subject><subject>Lung</subject><subject>Lungs</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - drug therapy</subject><subject>Lupus nephritis</subject><subject>Lupus Nephritis - complications</subject><subject>Lupus Nephritis - drug therapy</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Multiple Organ Failure - etiology</subject><subject>Necrosis</subject><subject>Patients</subject><subject>Pharyngitis</subject><subject>Systemic lupus erythematosus</subject><subject>Tonsillitis</subject><subject>Uterus</subject><subject>Viral infections</subject><subject>Young Adult</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc2L1TAUxYMoznN070oCbtxUc5M2bZby8AsG3Oi6pMnta4Z-mZui79_wLzbljSID4iLkkvM7J1wOY89BvAao6zfCaJBCKZBl1TQlPGAHKOu6yO_yITvscrHrV-wJ0a0QQoHRj9mVlEYJKaoD-3m0yVKKyzoEx-2cwjoslM8Y1uA5nWcflwl5iuF0woied2feb-MU5gxzH4hwn1NWBowrEqcwrSP-4GHu0aWwzHnilq82BcyW7yENOZdS9jk-butGHOM5DTjZtNBGT9mj3o6Ez-7ua_b1_bsvx4_FzecPn45vbwqnTJOKpvLeaF0a25RN5xunwYLXqjNGVx2AdgpcWaNpsBO9F5WE3gGoOm-eMa2u2atL7hqXbxtSaqdADsfRzrhs1EKGJci6Nv9HRQOlysEyoy_vobfLFue8yE4JDSAkZEpcKBcXooh9u8Yw2XjOULtX296vNlte3AVv3YT-j-F3lxkoLgDZE_796z8CfwF_Lq2P</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Catoggio, C</creator><creator>Alvarez-Uría, A</creator><creator>Fernandez, PL</creator><creator>Cervera, R</creator><creator>Espinosa, G</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U9</scope></search><sort><creationdate>201210</creationdate><title>Catastrophic antiphospholipid syndrome triggered by fulminant disseminated herpes simplex infection in a patient with systemic lupus erythematosus</title><author>Catoggio, C ; Alvarez-Uría, A ; Fernandez, PL ; Cervera, R ; Espinosa, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-85dd96649a848bd8c61a1d63b9965b116c31c47e98eb0fd0521fc1137302d6363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdomen</topic><topic>Antibodies</topic><topic>Antibodies, Antiphospholipid - immunology</topic><topic>Anticoagulants</topic><topic>antiphospholipid antibodies</topic><topic>antiphospholipid syndrome</topic><topic>Antiphospholipid Syndrome - etiology</topic><topic>Antiphospholipid Syndrome - immunology</topic><topic>Antiphospholipid Syndrome - physiopathology</topic><topic>Arterioles</topic><topic>Autoimmune diseases</topic><topic>Case reports</topic><topic>Catastrophic Illness</topic><topic>Cervicitis</topic><topic>Disseminated infection</topic><topic>Endothelium</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Hepatitis</topic><topic>Herpes simplex</topic><topic>Herpes Simplex - etiology</topic><topic>Herpes Simplex - physiopathology</topic><topic>Herpes simplex virus</topic><topic>Herpes viruses</topic><topic>Humans</topic><topic>Immunosuppressive agents</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Infections</topic><topic>Liver</topic><topic>Lung</topic><topic>Lungs</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - drug therapy</topic><topic>Lupus nephritis</topic><topic>Lupus Nephritis - complications</topic><topic>Lupus Nephritis - drug therapy</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Multiple Organ Failure - etiology</topic><topic>Necrosis</topic><topic>Patients</topic><topic>Pharyngitis</topic><topic>Systemic lupus erythematosus</topic><topic>Tonsillitis</topic><topic>Uterus</topic><topic>Viral infections</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Catoggio, C</creatorcontrib><creatorcontrib>Alvarez-Uría, A</creatorcontrib><creatorcontrib>Fernandez, PL</creatorcontrib><creatorcontrib>Cervera, R</creatorcontrib><creatorcontrib>Espinosa, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Catoggio, C</au><au>Alvarez-Uría, A</au><au>Fernandez, PL</au><au>Cervera, R</au><au>Espinosa, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Catastrophic antiphospholipid syndrome triggered by fulminant disseminated herpes simplex infection in a patient with systemic lupus erythematosus</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2012-10</date><risdate>2012</risdate><volume>21</volume><issue>12</issue><spage>1359</spage><epage>1361</epage><pages>1359-1361</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Infections are considered one of the most common causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE), and occasionally can trigger a catastrophic antiphospholipid syndrome (APS). We describe a 22-year-old SLE patient with lupus nephritis under immunosuppressant therapy and asymptomatic carrier of antiphospholipid antibodies, who was admitted with tonsillitis and acute hepatitis, developing multiorgan failure in a few hours. Postmortem examination revealed hepatic necrosis, tonsillitis, pharyngitis and uterine cervicitis caused by herpes simplex virus (HSV) together with microthrombosis in lungs and glomerular arterioles, suggesting the diagnosis of fulminant HSV disseminated infection and catastrophic APS.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22930205</pmid><doi>10.1177/0961203312458841</doi><tpages>3</tpages></addata></record> |
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| ispartof | Lupus, 2012-10, Vol.21 (12), p.1359-1361 |
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| subjects | Abdomen Antibodies Antibodies, Antiphospholipid - immunology Anticoagulants antiphospholipid antibodies antiphospholipid syndrome Antiphospholipid Syndrome - etiology Antiphospholipid Syndrome - immunology Antiphospholipid Syndrome - physiopathology Arterioles Autoimmune diseases Case reports Catastrophic Illness Cervicitis Disseminated infection Endothelium Fatal Outcome Female Hepatitis Herpes simplex Herpes Simplex - etiology Herpes Simplex - physiopathology Herpes simplex virus Herpes viruses Humans Immunosuppressive agents Immunosuppressive Agents - therapeutic use Infections Liver Lung Lungs Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - drug therapy Lupus nephritis Lupus Nephritis - complications Lupus Nephritis - drug therapy Morbidity Mortality Multiple Organ Failure - etiology Necrosis Patients Pharyngitis Systemic lupus erythematosus Tonsillitis Uterus Viral infections Young Adult |
| title | Catastrophic antiphospholipid syndrome triggered by fulminant disseminated herpes simplex infection in a patient with systemic lupus erythematosus |
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