Concurrent use of indacaterol plus tiotropium in patients with COPD provides superior bronchodilation compared with tiotropium alone: a randomised, double-blind comparison

BackgroundCurrent guidelines recommend treatment with one or more long-acting bronchodilators for patients with moderate or more severe chronic obstructive pulmonary disease (COPD). The authors investigated the approach of dual bronchodilation using indacaterol, a once-daily long-acting β2 agonist,...

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Veröffentlicht in:	Thorax 2012-09, Vol.67 (9), p.781-788
Hauptverfasser:	Mahler, Donald A, D'Urzo, Anthony, Bateman, Eric D, Özkan, Serir A, White, Tracy, Peckitt, Clare, Lassen, Cheryl, Kramer, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - therapeutic use Adult Analysis of Variance Area Under Curve asthma asthma epidemiology asthma guidelines asthma in primary care asthma pharmacology Biological and medical sciences Bronchodilator Agents - therapeutic use Cardiology. Vascular system chronic obstructive Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma COPD epidemiology COPD exacerbations COPD mechanisms COPD pharmacology Double-Blind Method Drug Therapy, Combination Effectiveness exercise Female Humans Indacaterol Indans - therapeutic use inhaler devices Least-Squares Analysis lung cancer Male Medical sciences Middle Aged Patients perception of asthma/breathlessness Placebos pleural disease Pneumology pulmonary disease Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - physiopathology pulmonary embolism Quinolones - therapeutic use Respiratory Function Tests Scopolamine Derivatives - therapeutic use Severity of Illness Index tiotropium Tiotropium Bromide Treatment Outcome tuberculosis
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