miRNA-218 contributes to the regulation of D-glucuronyl C5-epimerase expression in normal and tumor breast tissues

microRNAs (miRNAs) are key posttranscriptional regulators of gene expression. In the present study, regulation of tumor-suppressor gene D-glucuronyl C5-epimerase (GLCE) by miRNA-218 was investigated. Significant downregulation of miRNA-218 expression was shown in primary breast tumors. Exogenous miR...

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Veröffentlicht in:	Epigenetics 2012-10, Vol.7 (10), p.1109-1114
Hauptverfasser:	Prudnikova, Tatiana Y, Mostovich, Luydmila A, Kashuba, Vladimir I, Ernberg, Ingemar, Zabarovsky, Eugene R, Grigorieva, Elvira V
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biology Bioscience biosynthesis breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Brief Report Calcium Cancer Carbohydrate Epimerases - genetics Carbohydrate Epimerases - metabolism Cell Cycle D-glucuronyl C5-epimerase expression Female Gene Expression Regulation, Neoplastic GLCE heparan sulphate proteoglycan Humans Landes MCF-7 Cells MicroRNAs - genetics MicroRNAs - metabolism miRNA Organogenesis Proteins RNA, Messenger - genetics TECHNOLOGY TEKNIKVETENSKAP tumor-suppressor gene
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