Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1

Acetyl salicylic acid (ASA) is one of the most frequently prescribed medications for the secondary prevention of cardiovascular and cerebrovascular events. It has recently been reported to cause small intestinal mucosal injury at a considerably higher rate than previously believed. The aim of this s...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2012-10, Vol.303 (8), p.G927-G936
Hauptverfasser:	Fukui, Akifumi, Naito, Yuji, Handa, Osamu, Kugai, Munehiro, Tsuji, Toshifumi, Yoriki, Hiroyuki, Qin, Ying, Adachi, Satoko, Higashimura, Yasuki, Mizushima, Katsura, Kamada, Kazuhiro, Katada, Kazuhiro, Uchiyama, Kazuhiko, Ishikawa, Takeshi, Takagi, Tomohisa, Yagi, Nobuaki, Kokura, Satoshi, Yoshikawa, Toshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aspirin - pharmacology Cell Line, Tumor Cellular biology Gene expression Humans Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine, Small - drug effects Intestine, Small - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Permeability Proteins Reactive Oxygen Species - metabolism Small intestine Tight Junctions - metabolism Zonula Occludens-1 Protein - metabolism
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