Involvement of platelet derived microparticles in tumor metastasis and tissue regeneration
Abstract Platelets play a major role in hemostasis, but are also involved in vascular biology processes such as angiogenesis and tumor metastasis. Activated platelets release many proteins favoring wound healing and promoting angiogenesis. Microparticles (MP) are small plasma membrane vesicles shed...
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| Veröffentlicht in: | Thrombosis research 2012-10, Vol.130, p.S98-S99 |
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| container_title | Thrombosis research |
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| creator | Varon, David Hayon, Yael Dashevsky, Olga Shai, Ela |
| description | Abstract Platelets play a major role in hemostasis, but are also involved in vascular biology processes such as angiogenesis and tumor metastasis. Activated platelets release many proteins favoring wound healing and promoting angiogenesis. Microparticles (MP) are small plasma membrane vesicles shed from cells upon their activation or apoptosis. Platelet-derived microparticles (PMP) constitute the majority of the pool of MP circulating in the blood. PMP express and may transfer functional receptors, stimulate the release of cytokines, activate intracellular signaling pathways, promote angiogenesis, and are involved in tissue regeneration and cancer metastasis. We investigated the effect of PMP on cancer cells metastasis and their potential beneficial effect in an ischemic stroke model. |
| doi_str_mv | 10.1016/j.thromres.2012.08.289 |
| format | Article |
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Activated platelets release many proteins favoring wound healing and promoting angiogenesis. Microparticles (MP) are small plasma membrane vesicles shed from cells upon their activation or apoptosis. Platelet-derived microparticles (PMP) constitute the majority of the pool of MP circulating in the blood. PMP express and may transfer functional receptors, stimulate the release of cytokines, activate intracellular signaling pathways, promote angiogenesis, and are involved in tissue regeneration and cancer metastasis. We investigated the effect of PMP on cancer cells metastasis and their potential beneficial effect in an ischemic stroke model.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2012.08.289</identifier><identifier>PMID: 23026678</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; Apoptosis ; Blood Platelets - metabolism ; Blood Platelets - pathology ; Brain - blood supply ; Brain - metabolism ; Brain - pathology ; Brain - physiopathology ; Cell Proliferation ; Cell-Derived Microparticles - metabolism ; Cell-Derived Microparticles - pathology ; Disease Models, Animal ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Infarction, Middle Cerebral Artery - blood ; Infarction, Middle Cerebral Artery - pathology ; Infarction, Middle Cerebral Artery - physiopathology ; Lung Neoplasms - blood ; Lung Neoplasms - blood supply ; Lung Neoplasms - secondary ; Male ; Mice ; Neoplasm Invasiveness ; Neovascularization, Pathologic ; Neovascularization, Physiologic ; Neurogenesis ; Platelet Activation ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - blood supply ; Prostatic Neoplasms - pathology ; Rats ; Regeneration ; Signal Transduction</subject><ispartof>Thrombosis research, 2012-10, Vol.130, p.S98-S99</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-aea0917db020f134179146db611450080b1f178aa6565f74306bf42579ba6d133</citedby><cites>FETCH-LOGICAL-c423t-aea0917db020f134179146db611450080b1f178aa6565f74306bf42579ba6d133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0049384812006615$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23026678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Varon, David</creatorcontrib><creatorcontrib>Hayon, Yael</creatorcontrib><creatorcontrib>Dashevsky, Olga</creatorcontrib><creatorcontrib>Shai, Ela</creatorcontrib><title>Involvement of platelet derived microparticles in tumor metastasis and tissue regeneration</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Abstract Platelets play a major role in hemostasis, but are also involved in vascular biology processes such as angiogenesis and tumor metastasis. Activated platelets release many proteins favoring wound healing and promoting angiogenesis. Microparticles (MP) are small plasma membrane vesicles shed from cells upon their activation or apoptosis. Platelet-derived microparticles (PMP) constitute the majority of the pool of MP circulating in the blood. PMP express and may transfer functional receptors, stimulate the release of cytokines, activate intracellular signaling pathways, promote angiogenesis, and are involved in tissue regeneration and cancer metastasis. We investigated the effect of PMP on cancer cells metastasis and their potential beneficial effect in an ischemic stroke model.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Blood Platelets - metabolism</subject><subject>Blood Platelets - pathology</subject><subject>Brain - blood supply</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Cell Proliferation</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>Cell-Derived Microparticles - pathology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Infarction, Middle Cerebral Artery - blood</subject><subject>Infarction, Middle Cerebral Artery - pathology</subject><subject>Infarction, Middle Cerebral Artery - physiopathology</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - blood supply</subject><subject>Lung Neoplasms - secondary</subject><subject>Male</subject><subject>Mice</subject><subject>Neoplasm Invasiveness</subject><subject>Neovascularization, Pathologic</subject><subject>Neovascularization, Physiologic</subject><subject>Neurogenesis</subject><subject>Platelet Activation</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - blood supply</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Rats</subject><subject>Regeneration</subject><subject>Signal Transduction</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EokvhL1Q-ckmYcRzbuSBQVaBSJQ7AhYvlJBPwktiL7azUf09W23LggjTSXN6bp_cNY1cINQKqN_u6_ExxSZRrAShqMLUw3RO2Q6O7SkgtnrIdgOyqxkhzwV7kvAdAjV37nF2IBoRS2uzY99twjPORFgqFx4kfZldopsJHSv5II1_8kOLBpeKHmTL3gZd1iYkvVFzexmfuwsiLz3klnugHBUqu-BhesmeTmzO9etiX7NuHm6_Xn6q7zx9vr9_fVYMUTakcOehQjz0ImLCRqDuUauwVomwBDPQ4oTbOqVa1k5YNqH6SotVd79SITXPJXp_vHlL8vVIudvF5oHl2geKaLSIKpbU0ZpOqs3TrlHOiyR6SX1y6twj2xNXu7SNXe-JqwdiN62a8eshY-4XGv7ZHkJvg3VlAW9Ojp2Tz4CkMNPpEQ7Fj9P_PePvPiWH2wQ9u_kX3lPdxTWHjaNHmzWO_nL57ei4KAKWwbf4AR3uiuA</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Varon, David</creator><creator>Hayon, Yael</creator><creator>Dashevsky, Olga</creator><creator>Shai, Ela</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Involvement of platelet derived microparticles in tumor metastasis and tissue regeneration</title><author>Varon, David ; Hayon, Yael ; Dashevsky, Olga ; Shai, Ela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-aea0917db020f134179146db611450080b1f178aa6565f74306bf42579ba6d133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Blood Platelets - metabolism</topic><topic>Blood Platelets - pathology</topic><topic>Brain - blood supply</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Cell Proliferation</topic><topic>Cell-Derived Microparticles - metabolism</topic><topic>Cell-Derived Microparticles - pathology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Infarction, Middle Cerebral Artery - blood</topic><topic>Infarction, Middle Cerebral Artery - pathology</topic><topic>Infarction, Middle Cerebral Artery - physiopathology</topic><topic>Lung Neoplasms - blood</topic><topic>Lung Neoplasms - blood supply</topic><topic>Lung Neoplasms - secondary</topic><topic>Male</topic><topic>Mice</topic><topic>Neoplasm Invasiveness</topic><topic>Neovascularization, Pathologic</topic><topic>Neovascularization, Physiologic</topic><topic>Neurogenesis</topic><topic>Platelet Activation</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - blood supply</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Rats</topic><topic>Regeneration</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Varon, David</creatorcontrib><creatorcontrib>Hayon, Yael</creatorcontrib><creatorcontrib>Dashevsky, Olga</creatorcontrib><creatorcontrib>Shai, Ela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Varon, David</au><au>Hayon, Yael</au><au>Dashevsky, Olga</au><au>Shai, Ela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of platelet derived microparticles in tumor metastasis and tissue regeneration</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>130</volume><spage>S98</spage><epage>S99</epage><pages>S98-S99</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><abstract>Abstract Platelets play a major role in hemostasis, but are also involved in vascular biology processes such as angiogenesis and tumor metastasis. Activated platelets release many proteins favoring wound healing and promoting angiogenesis. Microparticles (MP) are small plasma membrane vesicles shed from cells upon their activation or apoptosis. Platelet-derived microparticles (PMP) constitute the majority of the pool of MP circulating in the blood. PMP express and may transfer functional receptors, stimulate the release of cytokines, activate intracellular signaling pathways, promote angiogenesis, and are involved in tissue regeneration and cancer metastasis. We investigated the effect of PMP on cancer cells metastasis and their potential beneficial effect in an ischemic stroke model.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>23026678</pmid><doi>10.1016/j.thromres.2012.08.289</doi></addata></record> |
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| ispartof | Thrombosis research, 2012-10, Vol.130, p.S98-S99 |
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| language | eng |
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| subjects | Animals Apoptosis Blood Platelets - metabolism Blood Platelets - pathology Brain - blood supply Brain - metabolism Brain - pathology Brain - physiopathology Cell Proliferation Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - pathology Disease Models, Animal Female Hematology, Oncology and Palliative Medicine Humans Infarction, Middle Cerebral Artery - blood Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Lung Neoplasms - blood Lung Neoplasms - blood supply Lung Neoplasms - secondary Male Mice Neoplasm Invasiveness Neovascularization, Pathologic Neovascularization, Physiologic Neurogenesis Platelet Activation Prostatic Neoplasms - blood Prostatic Neoplasms - blood supply Prostatic Neoplasms - pathology Rats Regeneration Signal Transduction |
| title | Involvement of platelet derived microparticles in tumor metastasis and tissue regeneration |
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