Association of the miR-146aC>G, 149C>T, 196a2C>T, and 499A>G polymorphisms with colorectal cancer in the Korean population
MicroRNAs (miRNAs) are small, 18‐ to 22‐nucleotide non‐coding RNAs that regulate target gene expression. Although recent studies focused on various diseases that harbor the miR‐146aC>G (rs2910164), 149C>T (rs2292832), 196a2C>T (rs11614913), and 499A>G (rs3746444) polymorphisms, the role...
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| Veröffentlicht in: | Molecular carcinogenesis 2012-10, Vol.51 (S1), p.E65-E73 |
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| container_title | Molecular carcinogenesis |
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| creator | Min, Kyung Tae Kim, Jong Woo Jeon, Young Joo Jang, Moon Ju Chong, So Young Oh, Doyeun Kim, Nam Keun |
| description | MicroRNAs (miRNAs) are small, 18‐ to 22‐nucleotide non‐coding RNAs that regulate target gene expression. Although recent studies focused on various diseases that harbor the miR‐146aC>G (rs2910164), 149C>T (rs2292832), 196a2C>T (rs11614913), and 499A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown. The present study aimed to evaluate the role of four miRNA polymorphisms in patients with colorectal cancer. We enrolled 446 colorectal cancer patients and 502 control subjects from the Korean population. We found a significantly increased colorectal cancer risk with the miR‐196a2CC genotype compared with the TT/CT genotype (AOR = 1.50; 95% CI = 1.11–2.04; P = 0.01; FDR‐P = 0.04). In the stratified analyses, we observed both weak and strong association data. We found stronger associations of the miR‐196a2 variants in the non‐diabetic and rectal cancer groups than other stratified groups. Our data suggest that the miRNA variants could affect the development of colorectal cancer in the Korean population. © 2011 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/mc.21849 |
| format | Article |
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Our data suggest that the miRNA variants could affect the development of colorectal cancer in the Korean population. © 2011 Wiley Periodicals, Inc.</description><identifier>ISSN: 0899-1987</identifier><identifier>EISSN: 1098-2744</identifier><identifier>DOI: 10.1002/mc.21849</identifier><identifier>PMID: 22161766</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Asian Continental Ancestry Group - genetics ; Case-Control Studies ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Genetic Predisposition to Disease ; Humans ; Male ; microRNA ; MicroRNAs ; Middle Aged ; Polymorphism ; Polymorphism, Single Nucleotide ; Population genetics ; Random Allocation</subject><ispartof>Molecular carcinogenesis, 2012-10, Vol.51 (S1), p.E65-E73</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmc.21849$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmc.21849$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22161766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Min, Kyung Tae</creatorcontrib><creatorcontrib>Kim, Jong Woo</creatorcontrib><creatorcontrib>Jeon, Young Joo</creatorcontrib><creatorcontrib>Jang, Moon Ju</creatorcontrib><creatorcontrib>Chong, So Young</creatorcontrib><creatorcontrib>Oh, Doyeun</creatorcontrib><creatorcontrib>Kim, Nam Keun</creatorcontrib><title>Association of the miR-146aC>G, 149C>T, 196a2C>T, and 499A>G polymorphisms with colorectal cancer in the Korean population</title><title>Molecular carcinogenesis</title><addtitle>Mol. Carcinog</addtitle><description>MicroRNAs (miRNAs) are small, 18‐ to 22‐nucleotide non‐coding RNAs that regulate target gene expression. Although recent studies focused on various diseases that harbor the miR‐146aC>G (rs2910164), 149C>T (rs2292832), 196a2C>T (rs11614913), and 499A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown. The present study aimed to evaluate the role of four miRNA polymorphisms in patients with colorectal cancer. We enrolled 446 colorectal cancer patients and 502 control subjects from the Korean population. We found a significantly increased colorectal cancer risk with the miR‐196a2CC genotype compared with the TT/CT genotype (AOR = 1.50; 95% CI = 1.11–2.04; P = 0.01; FDR‐P = 0.04). In the stratified analyses, we observed both weak and strong association data. We found stronger associations of the miR‐196a2 variants in the non‐diabetic and rectal cancer groups than other stratified groups. 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Carcinog</addtitle><date>2012-10</date><risdate>2012</risdate><volume>51</volume><issue>S1</issue><spage>E65</spage><epage>E73</epage><pages>E65-E73</pages><issn>0899-1987</issn><eissn>1098-2744</eissn><abstract>MicroRNAs (miRNAs) are small, 18‐ to 22‐nucleotide non‐coding RNAs that regulate target gene expression. Although recent studies focused on various diseases that harbor the miR‐146aC>G (rs2910164), 149C>T (rs2292832), 196a2C>T (rs11614913), and 499A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown. The present study aimed to evaluate the role of four miRNA polymorphisms in patients with colorectal cancer. We enrolled 446 colorectal cancer patients and 502 control subjects from the Korean population. We found a significantly increased colorectal cancer risk with the miR‐196a2CC genotype compared with the TT/CT genotype (AOR = 1.50; 95% CI = 1.11–2.04; P = 0.01; FDR‐P = 0.04). 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| subjects | Aged Asian Continental Ancestry Group - genetics Case-Control Studies Colorectal cancer Colorectal Neoplasms - genetics Genetic Predisposition to Disease Humans Male microRNA MicroRNAs Middle Aged Polymorphism Polymorphism, Single Nucleotide Population genetics Random Allocation |
| title | Association of the miR-146aC>G, 149C>T, 196a2C>T, and 499A>G polymorphisms with colorectal cancer in the Korean population |
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