Protective effect of annexin‐A1 against irreversible damage to cavernous tissue after cavernous nerve injury in the rat
Study Type – Aetiology (case control) Level of Evidence 3b What's known on the subject? and What does the study add? Penile rehabilitation is still controversial regarding good results. Our study shows a non‐invasive treatment option to recovery after cavernous nervous damage. The assessment of...
Gespeichert in:
| Veröffentlicht in: | BJU international 2012-11, Vol.110 (9), p.1346-1351 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1351 |
|---|---|
| container_issue | 9 |
| container_start_page | 1346 |
| container_title | BJU international |
| container_volume | 110 |
| creator | Facio Jr, Fernando N. Burnett, Arthur L. |
| description | Study Type – Aetiology (case control)
Level of Evidence 3b
What's known on the subject? and What does the study add?
Penile rehabilitation is still controversial regarding good results. Our study shows a non‐invasive treatment option to recovery after cavernous nervous damage.
The assessment of changes in the intracavernous pressure and karyometry demonstrates the protective effect of annexin‐A1 in an animal model of cavernous nerve injury. We found that annexin‐A1 effectively preserved erectile function, evidently through significantly protecting the corpus cavernosum tissue against fibrosis.
OBJECTIVE
•
To evaluate the protective effect of annexin‐A1 against irreversible damage to cavernous tissue after cavernous nerve injury.
PATIENTS AND METHODS
•
Thirty Sprague‐Dawley male rats were divided into 3 groups; sham‐operated rats (n= 10), bilateral cavernous nerve injury treated intravenously with 100 µg/kg annexin‐A1 (n= 10), and a crush group of rats submitted to bilateral cavernous nerve injury and vehicle (n= 10). Groups were compared in respect to intracavernous pressure and karyometric parameters.
RESULTS
•
After annexin‐A1 treatment, the maximum changes in intracavernous pressure responses were significantly higher in the annexin‐A1 group compared to the vehicle‐only group on the 7th postoperative day (p‐value |
| doi_str_mv | 10.1111/j.1464-410X.2012.11097.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1112676865</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1112676865</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4287-c9dc239c67061b071fc24c20540b608513b514280249376666952fbd16ec476a3</originalsourceid><addsrcrecordid>eNqNkUtOHDEQhq0IFB7JFSJLEVI2M_jRdndvIgHiKaRkEaTsLLenTNzqcRPbTWZ2HIEzchLczEAQK2pTpd9flX9VIYQpmdIc--2UFrKYFJT8njJCWVZJXU4XH9D2y8PGc01quYV2YmwJyYIUH9EWY4IRxuU2Wv4MfQKT3C1gsDZXuLdYew8L5x_u7g8o1tfa-ZiwCwFuIUTXdIBneq6vAaceG51F3w8RJxfjAFjbBOGV7CHk4c63Q1jmhNMfwEGnT2jT6i7C53XeRVcnx7-OziaXP07Pjw4uJ6ZgVTkx9cwwXhtZEkkbUlJrWGEYEQVpJKkE5Y2gmSSsqHkpc9SC2WZGJZiilJrvom-ruTeh_ztATGruooGu0x6yPZX3yWQpKyky-vUN2vZD8NmdolxwLiktWaaqFWVCH2MAq26Cm-uwVJSM06hq1bh5NV5BjedRT-dRi9z6Zf3B0Mxh9tL4fI8M7K0BHY3ubNDeuPifk0LWVT16-L7i_rkOlu82oA4vrp5K_gjuwau0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1353361172</pqid></control><display><type>article</type><title>Protective effect of annexin‐A1 against irreversible damage to cavernous tissue after cavernous nerve injury in the rat</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Facio Jr, Fernando N. ; Burnett, Arthur L.</creator><creatorcontrib>Facio Jr, Fernando N. ; Burnett, Arthur L.</creatorcontrib><description>Study Type – Aetiology (case control)
Level of Evidence 3b
What's known on the subject? and What does the study add?
Penile rehabilitation is still controversial regarding good results. Our study shows a non‐invasive treatment option to recovery after cavernous nervous damage.
The assessment of changes in the intracavernous pressure and karyometry demonstrates the protective effect of annexin‐A1 in an animal model of cavernous nerve injury. We found that annexin‐A1 effectively preserved erectile function, evidently through significantly protecting the corpus cavernosum tissue against fibrosis.
OBJECTIVE
•
To evaluate the protective effect of annexin‐A1 against irreversible damage to cavernous tissue after cavernous nerve injury.
PATIENTS AND METHODS
•
Thirty Sprague‐Dawley male rats were divided into 3 groups; sham‐operated rats (n= 10), bilateral cavernous nerve injury treated intravenously with 100 µg/kg annexin‐A1 (n= 10), and a crush group of rats submitted to bilateral cavernous nerve injury and vehicle (n= 10). Groups were compared in respect to intracavernous pressure and karyometric parameters.
RESULTS
•
After annexin‐A1 treatment, the maximum changes in intracavernous pressure responses were significantly higher in the annexin‐A1 group compared to the vehicle‐only group on the 7th postoperative day (p‐value <0.05). Hematoxylin‐eosin staining showed that the percentage of cavernosal smooth muscle was higher in the annexin‐A1 group. Karyometry showed that the nuclear volume was greater in the annexin‐A1 group, as was the major/minor smooth muscle cell diameter ratio compared to the vehicle‐only group on the 7th postoperative day (p‐value <0.05).
CONCLUSION
•
This is the first report that, by assessing changes in the intracavernous pressure and karyometry, demonstrates the protective effect of annexin‐A1 in an animal model of cavernous nerve injury. We found that annexin‐A1 effectively preserved erectile function, evidently through significantly protecting the corpus cavernosum tissue against fibrosis.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/j.1464-410X.2012.11097.x</identifier><identifier>PMID: 22520236</identifier><identifier>CODEN: BJINFO</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>animal model ; Animals ; Annexin A1 - pharmacology ; Biological and medical sciences ; erectile dysfunction ; Erectile Dysfunction - prevention & control ; Gynecology. Andrology. Obstetrics ; inflammation ; Male ; Male genital diseases ; Medical sciences ; Nephrology. Urinary tract diseases ; neuropraxia ; Neuroprotective Agents - pharmacology ; Non tumoral diseases ; Penis - injuries ; Penis - innervation ; Pressure ; Rats ; Rats, Sprague-Dawley ; Trauma, Nervous System</subject><ispartof>BJU international, 2012-11, Vol.110 (9), p.1346-1351</ispartof><rights>2012 BJU INTERNATIONAL</rights><rights>2015 INIST-CNRS</rights><rights>2012 BJU INTERNATIONAL.</rights><rights>BJUI © 2012 BJU International</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4287-c9dc239c67061b071fc24c20540b608513b514280249376666952fbd16ec476a3</citedby><cites>FETCH-LOGICAL-c4287-c9dc239c67061b071fc24c20540b608513b514280249376666952fbd16ec476a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-410X.2012.11097.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-410X.2012.11097.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26569892$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22520236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Facio Jr, Fernando N.</creatorcontrib><creatorcontrib>Burnett, Arthur L.</creatorcontrib><title>Protective effect of annexin‐A1 against irreversible damage to cavernous tissue after cavernous nerve injury in the rat</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>Study Type – Aetiology (case control)
Level of Evidence 3b
What's known on the subject? and What does the study add?
Penile rehabilitation is still controversial regarding good results. Our study shows a non‐invasive treatment option to recovery after cavernous nervous damage.
The assessment of changes in the intracavernous pressure and karyometry demonstrates the protective effect of annexin‐A1 in an animal model of cavernous nerve injury. We found that annexin‐A1 effectively preserved erectile function, evidently through significantly protecting the corpus cavernosum tissue against fibrosis.
OBJECTIVE
•
To evaluate the protective effect of annexin‐A1 against irreversible damage to cavernous tissue after cavernous nerve injury.
PATIENTS AND METHODS
•
Thirty Sprague‐Dawley male rats were divided into 3 groups; sham‐operated rats (n= 10), bilateral cavernous nerve injury treated intravenously with 100 µg/kg annexin‐A1 (n= 10), and a crush group of rats submitted to bilateral cavernous nerve injury and vehicle (n= 10). Groups were compared in respect to intracavernous pressure and karyometric parameters.
RESULTS
•
After annexin‐A1 treatment, the maximum changes in intracavernous pressure responses were significantly higher in the annexin‐A1 group compared to the vehicle‐only group on the 7th postoperative day (p‐value <0.05). Hematoxylin‐eosin staining showed that the percentage of cavernosal smooth muscle was higher in the annexin‐A1 group. Karyometry showed that the nuclear volume was greater in the annexin‐A1 group, as was the major/minor smooth muscle cell diameter ratio compared to the vehicle‐only group on the 7th postoperative day (p‐value <0.05).
CONCLUSION
•
This is the first report that, by assessing changes in the intracavernous pressure and karyometry, demonstrates the protective effect of annexin‐A1 in an animal model of cavernous nerve injury. We found that annexin‐A1 effectively preserved erectile function, evidently through significantly protecting the corpus cavernosum tissue against fibrosis.</description><subject>animal model</subject><subject>Animals</subject><subject>Annexin A1 - pharmacology</subject><subject>Biological and medical sciences</subject><subject>erectile dysfunction</subject><subject>Erectile Dysfunction - prevention & control</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>inflammation</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>neuropraxia</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Non tumoral diseases</subject><subject>Penis - injuries</subject><subject>Penis - innervation</subject><subject>Pressure</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Trauma, Nervous System</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtOHDEQhq0IFB7JFSJLEVI2M_jRdndvIgHiKaRkEaTsLLenTNzqcRPbTWZ2HIEzchLczEAQK2pTpd9flX9VIYQpmdIc--2UFrKYFJT8njJCWVZJXU4XH9D2y8PGc01quYV2YmwJyYIUH9EWY4IRxuU2Wv4MfQKT3C1gsDZXuLdYew8L5x_u7g8o1tfa-ZiwCwFuIUTXdIBneq6vAaceG51F3w8RJxfjAFjbBOGV7CHk4c63Q1jmhNMfwEGnT2jT6i7C53XeRVcnx7-OziaXP07Pjw4uJ6ZgVTkx9cwwXhtZEkkbUlJrWGEYEQVpJKkE5Y2gmSSsqHkpc9SC2WZGJZiilJrvom-ruTeh_ztATGruooGu0x6yPZX3yWQpKyky-vUN2vZD8NmdolxwLiktWaaqFWVCH2MAq26Cm-uwVJSM06hq1bh5NV5BjedRT-dRi9z6Zf3B0Mxh9tL4fI8M7K0BHY3ubNDeuPifk0LWVT16-L7i_rkOlu82oA4vrp5K_gjuwau0</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Facio Jr, Fernando N.</creator><creator>Burnett, Arthur L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Protective effect of annexin‐A1 against irreversible damage to cavernous tissue after cavernous nerve injury in the rat</title><author>Facio Jr, Fernando N. ; Burnett, Arthur L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4287-c9dc239c67061b071fc24c20540b608513b514280249376666952fbd16ec476a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>animal model</topic><topic>Animals</topic><topic>Annexin A1 - pharmacology</topic><topic>Biological and medical sciences</topic><topic>erectile dysfunction</topic><topic>Erectile Dysfunction - prevention & control</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>inflammation</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>neuropraxia</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Non tumoral diseases</topic><topic>Penis - injuries</topic><topic>Penis - innervation</topic><topic>Pressure</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Trauma, Nervous System</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Facio Jr, Fernando N.</creatorcontrib><creatorcontrib>Burnett, Arthur L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Facio Jr, Fernando N.</au><au>Burnett, Arthur L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of annexin‐A1 against irreversible damage to cavernous tissue after cavernous nerve injury in the rat</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2012-11</date><risdate>2012</risdate><volume>110</volume><issue>9</issue><spage>1346</spage><epage>1351</epage><pages>1346-1351</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><coden>BJINFO</coden><abstract>Study Type – Aetiology (case control)
Level of Evidence 3b
What's known on the subject? and What does the study add?
Penile rehabilitation is still controversial regarding good results. Our study shows a non‐invasive treatment option to recovery after cavernous nervous damage.
The assessment of changes in the intracavernous pressure and karyometry demonstrates the protective effect of annexin‐A1 in an animal model of cavernous nerve injury. We found that annexin‐A1 effectively preserved erectile function, evidently through significantly protecting the corpus cavernosum tissue against fibrosis.
OBJECTIVE
•
To evaluate the protective effect of annexin‐A1 against irreversible damage to cavernous tissue after cavernous nerve injury.
PATIENTS AND METHODS
•
Thirty Sprague‐Dawley male rats were divided into 3 groups; sham‐operated rats (n= 10), bilateral cavernous nerve injury treated intravenously with 100 µg/kg annexin‐A1 (n= 10), and a crush group of rats submitted to bilateral cavernous nerve injury and vehicle (n= 10). Groups were compared in respect to intracavernous pressure and karyometric parameters.
RESULTS
•
After annexin‐A1 treatment, the maximum changes in intracavernous pressure responses were significantly higher in the annexin‐A1 group compared to the vehicle‐only group on the 7th postoperative day (p‐value <0.05). Hematoxylin‐eosin staining showed that the percentage of cavernosal smooth muscle was higher in the annexin‐A1 group. Karyometry showed that the nuclear volume was greater in the annexin‐A1 group, as was the major/minor smooth muscle cell diameter ratio compared to the vehicle‐only group on the 7th postoperative day (p‐value <0.05).
CONCLUSION
•
This is the first report that, by assessing changes in the intracavernous pressure and karyometry, demonstrates the protective effect of annexin‐A1 in an animal model of cavernous nerve injury. We found that annexin‐A1 effectively preserved erectile function, evidently through significantly protecting the corpus cavernosum tissue against fibrosis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22520236</pmid><doi>10.1111/j.1464-410X.2012.11097.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1464-4096 |
| ispartof | BJU international, 2012-11, Vol.110 (9), p.1346-1351 |
| issn | 1464-4096 1464-410X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1112676865 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | animal model Animals Annexin A1 - pharmacology Biological and medical sciences erectile dysfunction Erectile Dysfunction - prevention & control Gynecology. Andrology. Obstetrics inflammation Male Male genital diseases Medical sciences Nephrology. Urinary tract diseases neuropraxia Neuroprotective Agents - pharmacology Non tumoral diseases Penis - injuries Penis - innervation Pressure Rats Rats, Sprague-Dawley Trauma, Nervous System |
| title | Protective effect of annexin‐A1 against irreversible damage to cavernous tissue after cavernous nerve injury in the rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T01%3A11%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20effect%20of%20annexin%E2%80%90A1%20against%20irreversible%20damage%20to%20cavernous%20tissue%20after%20cavernous%20nerve%20injury%20in%20the%20rat&rft.jtitle=BJU%20international&rft.au=Facio%20Jr,%20Fernando%20N.&rft.date=2012-11&rft.volume=110&rft.issue=9&rft.spage=1346&rft.epage=1351&rft.pages=1346-1351&rft.issn=1464-4096&rft.eissn=1464-410X&rft.coden=BJINFO&rft_id=info:doi/10.1111/j.1464-410X.2012.11097.x&rft_dat=%3Cproquest_cross%3E1112676865%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1353361172&rft_id=info:pmid/22520236&rfr_iscdi=true |