Impact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles - Part II. Physicochemical characterisation of spray-dried materials

Objectives In this work we investigated the residual organic solvent content and physicochemical properties of spray‐dried chlorothiazide sodium (CTZNa) and potassium (CTZK) salts. Methods The powders were characterised by thermal, X‐ray diffraction, infrared and dynamic vapour sorption (DVS) anal...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2012-11, Vol.64 (11), p.1583-1591
Hauptverfasser:	Paluch, Krzysztof J., Tajber, Lidia, Amaro, Maria I., Corrigan, Owen I., Healy, Anne Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	amorphous Chemistry, Pharmaceutical - methods Chlorothiazide - chemistry Chromatography, Gas critical relative humidity of recrystallisation Drug Stability Drug Storage Organic Chemicals - chemistry oxidation of organic solvent Oxidation-Reduction permitted daily exposure Powders residual solvent level Solvents - chemistry spray-drying Temperature Transition Temperature X-Ray Diffraction
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