Impact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification system

Objectives  This work investigated the impact of spray drying variables such as feed concentration, solvent composition and the drying mode, on the micromeritic properties of chlorothiazide sodium (CTZNa) and chlorothiazide potassium (CTZK). Methods  Microparticles were prepared by spray drying and...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2012-11, Vol.64 (11), p.1570-1582
Hauptverfasser:	Paluch, Krzysztof J., Tajber, Lidia, Corrigan, Owen I., Healy, Anne Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	amorphous Chemistry, Pharmaceutical - methods Chlorothiazide - chemistry Helium - chemistry Microscopy, Electron, Scanning Microspheres morphology nanoporous microparticles Porosity Salts Solvents - chemistry specific surface area spray drying Surface Properties
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