TRPM7 Is Required for Breast Tumor Cell Metastasis

TRPM7 encodes a Ca2+-permeable nonselective cation channel with kinase activity. TRPM7 has been implicated in control of cell adhesion and migration, but whether TRPM7 activity contributes to cancer progression has not been established. Here we report that high levels of TRPM7 expression independent...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-08, Vol.72 (16), p.4250-4261
Hauptverfasser:	MIDDELBEEK, Jeroen, KUIPERS, Arthur J, SWEEP, Fred C. G. J, BULT, Peter, SPAN, Paul N, LEEUWEN, Frank N. Van, JALINK, Kees, HENNEMAN, Linda, VISSER, Daan, EIDHOF, Ilse, HORSSEN, Remco Van, WIERINGA, Bé, CANISIUS, Sander V, ZWART, Wilbert, WESSELS, Lodewyk F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Adhesion - physiology Cell Line, Tumor Cell Movement - physiology Cytoskeleton - drug effects Cytoskeleton - pathology Disease Progression Female Gene Knockdown Techniques Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Mice Mice, Transgenic Neoplasm Metastasis Neoplasm Staging Pharmacology. Drug treatments Protein-Serine-Threonine Kinases Receptors, Estrogen - biosynthesis Receptors, Estrogen - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics TRPM Cation Channels - biosynthesis TRPM Cation Channels - deficiency TRPM Cation Channels - genetics Tumors
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