Rapid Screening of ASXL1, IDH1, IDH2, and c-CBL Mutations in de Novo Acute Myeloid Leukemia by High-Resolution Melting

Recently, many novel molecular abnormalities were found to be distinctly associated with acute myeloid leukemia (AML). However, their clinical relevance and prognostic implications are not well established. We developed a new combination of high-resolution melting assays on a LightCycler 480 and dir...

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Veröffentlicht in:	The Journal of molecular diagnostics : JMD 2012-11, Vol.14 (6), p.594-601
Hauptverfasser:	Ibáñez, Mariam, Such, Esperanza, Cervera, José, Luna, Irene, Gómez-Seguí, Inés, López-Pavía, María, Dolz, Sandra, Barragán, Eva, Fuster, Oscar, Llop, Marta, Rodríguez-Veiga, Rebeca, Avaria, Amparo, Oltra, Silvestre, Senent, M. Leonor, Moscardó, Federico, Montesinos, Pau, Martínez-Cuadrón, David, Martín, Guillermo, Sanz, Miguel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Cohort Studies Female Genetic Testing - economics Genetic Testing - methods Humans Isocitrate Dehydrogenase - genetics Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Male Middle Aged Mutation Pathology Prognosis Proto-Oncogene Proteins c-cbl - genetics Repressor Proteins - genetics Time Factors Young Adult
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