Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor
Two faced nanoparticles: A zwitterionic polymer‐based nanoparticle with response to tumor acidity is developed for enhanced drug delivery to tumors. The nanoparticles are neutrally charged at physiological conditions and show prolonged circulation time; after leaking into tumor sites, in the acidic...
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| Veröffentlicht in: | Advanced materials (Weinheim) 2012-10, Vol.24 (40), p.5476-5480 |
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| container_issue | 40 |
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| container_title | Advanced materials (Weinheim) |
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| creator | Yuan, You-Yong Mao, Cheng-Qiong Du, Xiao-Jiao Du, Jin-Zhi Wang, Feng Wang, Jun |
| description | Two faced nanoparticles: A zwitterionic polymer‐based nanoparticle with response to tumor acidity is developed for enhanced drug delivery to tumors. The nanoparticles are neutrally charged at physiological conditions and show prolonged circulation time; after leaking into tumor sites, in the acidic extracellular tumor environment (pHe), nanoparticles are activated and become positively charged and are therefore efficiently taken up by tumor cells, leading to enhanced therapeutic effects in cancer treatment. |
| doi_str_mv | 10.1002/adma.201202296 |
| format | Article |
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| ispartof | Advanced materials (Weinheim), 2012-10, Vol.24 (40), p.5476-5480 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library |
| subjects | Animals Cell Line, Tumor controlled release Doxorubicin - administration & dosage Drug Carriers - chemistry drug delivery Humans Hydrogen-Ion Concentration Mice Mice, Nude micelles Nanoparticles - chemistry Neoplasms - drug therapy pH-responsive polymer Polyesters - chemistry Polymers - chemistry Transplantation, Heterologous zwitterionic |
| title | Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor |
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