A new nonestrogenic steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type I blocks the estrogen-dependent breast cancer tumor growth induced by estrone

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) converts estrone (E1) into estradiol (E2) and is expressed in many steroidogenic tissues and breast cancer cell lines. Because the potent estrogen E2 stimulates the growth and development of hormone-dependent diseases, inhibition of the final step o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer therapeutics 2012-10, Vol.11 (10), p.2096-2104
Hauptverfasser:	Ayan, Diana, Maltais, René, Roy, Jenny, Poirier, Donald
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors 17-Hydroxysteroid Dehydrogenases - metabolism Animals Breast Neoplasms - enzymology Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Drug Screening Assays, Antitumor Enzyme Inhibitors - blood Enzyme Inhibitors - pharmacology Estradiol - chemistry Estradiol - pharmacology Estrogen Receptor alpha - metabolism Estrogens - blood Estrogens - pharmacology Estrone - chemistry Estrone - pharmacology Female Humans Male Mice Mice, Inbred BALB C Mice, Nude Ovariectomy Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!