Metallo-β-lactamase-producing Pseudomonas aeruginosa in the Netherlands: the nationwide emergence of a single sequence type
Recently, the first outbreak of clonally related VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010–2011, which identified the presence of VIM-2 MBL-producing P. aeruginos...
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| Veröffentlicht in: | Clinical microbiology and infection 2012-09, Vol.18 (9), p.E369-E372 |
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| container_title | Clinical microbiology and infection |
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| creator | Van der Bij, A.K. Van der Zwan, D. Peirano, G. Severin, J.A. Pitout, J.D.D. Van Westreenen, M. Goessens, W.H.F. |
| description | Recently, the first outbreak of clonally related VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010–2011, which identified the presence of VIM-2 MBL-producing P. aeruginosa in 11 different hospitals. Genotyping by multiple-locus variable-number tandem-repeat analysis (MLVA) showed that the majority of the 82 MBL-producing isolates found belonged to a single MLVA type (n = 70, 85%), identified as STI11 by multilocus sequence typing (MLST). As MBL-producing isolates cause serious infections that are difficult to treat, the presence of clonally related isolates in various hospitals throughout the Netherlands is of nationwide concern. |
| doi_str_mv | 10.1111/j.1469-0691.2012.03969.x |
| format | Article |
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Subsequently, a nationwide surveillance study was performed in 2010–2011, which identified the presence of VIM-2 MBL-producing P. aeruginosa in 11 different hospitals. Genotyping by multiple-locus variable-number tandem-repeat analysis (MLVA) showed that the majority of the 82 MBL-producing isolates found belonged to a single MLVA type (n = 70, 85%), identified as STI11 by multilocus sequence typing (MLST). 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Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases</rights><rights>2012 The Authors. 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As MBL-producing isolates cause serious infections that are difficult to treat, the presence of clonally related isolates in various hospitals throughout the Netherlands is of nationwide concern.</description><subject>Antimicrobial resistance</subject><subject>beta-Lactam Resistance</subject><subject>beta-Lactamases - biosynthesis</subject><subject>beta-Lactamases - genetics</subject><subject>carbapenemase</subject><subject>Cross Infection - microbiology</subject><subject>Genotyping</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infection</subject><subject>Metallo- beta -lactamase</subject><subject>Microbial Sensitivity Tests</subject><subject>Minisatellite Repeats</subject><subject>molecular epidemiology</subject><subject>Multilocus Sequence Typing</subject><subject>Netherlands</subject><subject>nosocomial transmission</subject><subject>Nucleotide sequence</subject><subject>Phenotype</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - classification</subject><subject>Pseudomonas aeruginosa - enzymology</subject><subject>Pseudomonas aeruginosa - genetics</subject><subject>Pseudomonas aeruginosa - isolation & purification</subject><subject>Pseudomonas Infections - microbiology</subject><subject>Retrospective Studies</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUdtu1DAQjRAVvcAvID_yktS3ZG0kHmDFTdq2PIDEmzW1J4tXSbzYCe1KfBUfwjfh7Ja-tn4Yj8bnnBmfKQrCaMXyOd9UTDa6pI1mFaeMV1ToRle3T4qT-4enOWdalQspvh8XpyltKKVcCPmsOOZc0bph8qT4fYEjdF0o__4pO7Aj9JCw3MbgJuuHNfmScHKhDwMkAhintR9CAuIHMv5Acok5xg4Gl17vCwOMPgw33iHBHuMaB4sktARIymodkoQ_p31x3G3xeXHUQpfwxd19Vnz78P7r8lO5uvr4efl2VVrJ828EAgNO62vOed1SBgsNc2i1dLwFJRQq6VotmBQNdVRTK2slM5jaRikQZ8Wrg27-V26fRtP7ZLHLg2OYkpk9VbVaiPph6GytFo2SGaoOUBtDShFbs42-h7jLoL2k2Zh5G2ammHlNZr8mc5upL--6TNc9unvi_71kwJsD4MZ3uHu0sFmuLuYs898d-Jht_eUxmmT97LvzEe1oXPAPT_kPG-G3eg</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Van der Bij, A.K.</creator><creator>Van der Zwan, D.</creator><creator>Peirano, G.</creator><creator>Severin, J.A.</creator><creator>Pitout, J.D.D.</creator><creator>Van Westreenen, M.</creator><creator>Goessens, W.H.F.</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>201209</creationdate><title>Metallo-β-lactamase-producing Pseudomonas aeruginosa in the Netherlands: the nationwide emergence of a single sequence type</title><author>Van der Bij, A.K. ; 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antimicrobial resistance beta-Lactam Resistance beta-Lactamases - biosynthesis beta-Lactamases - genetics carbapenemase Cross Infection - microbiology Genotyping Hospitals Humans Infection Metallo- beta -lactamase Microbial Sensitivity Tests Minisatellite Repeats molecular epidemiology Multilocus Sequence Typing Netherlands nosocomial transmission Nucleotide sequence Phenotype Pseudomonas aeruginosa Pseudomonas aeruginosa - classification Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - microbiology Retrospective Studies |
| title | Metallo-β-lactamase-producing Pseudomonas aeruginosa in the Netherlands: the nationwide emergence of a single sequence type |
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