Surgical Indications for Gastrectomy Combined with Distal or Partial Pancreatectomy in Patients with Gastric Cancer
Background The purpose of this study was to clarify the surgical indications for gastrectomy combined with distal or partial pancreatectomy (GP) in patients with gastric cancer. Methods From January 1994 to December 2009, 29 patients with primary gastric cancer surgically invading the pancreas witho...
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| Veröffentlicht in: | World journal of surgery 2012-10, Vol.36 (10), p.2412-2419 |
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| creator | Sakamoto, Yasuo Sakaguchi, Yoshihisa Sugiyama, Masahiko Minami, Kazuhito Toh, Yasushi Okamura, Takeshi |
| description | Background
The purpose of this study was to clarify the surgical indications for gastrectomy combined with distal or partial pancreatectomy (GP) in patients with gastric cancer.
Methods
From January 1994 to December 2009, 29 patients with primary gastric cancer surgically invading the pancreas without distant organ metastasis underwent GP for R0 resection. The patients’ characteristics, surgical data, and clinicopathological features were used for the analysis of survival and prognostic factors.
Results
The median disease-free survival and median survival time (MST) of all patients were 15 and 30 months, respectively. Only pN3 status (characterized by 7 or more pathologically metastatic lymph nodes) according to the Japanese Classification of Gastric Carcinoma, 14th edition, was shown to be a prognostic factor in a multivariate analysis. The MST of the patients with pN3 and the other patients were 12 and 51 months, respectively (
p
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| doi_str_mv | 10.1007/s00268-012-1681-2 |
| format | Article |
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The purpose of this study was to clarify the surgical indications for gastrectomy combined with distal or partial pancreatectomy (GP) in patients with gastric cancer.
Methods
From January 1994 to December 2009, 29 patients with primary gastric cancer surgically invading the pancreas without distant organ metastasis underwent GP for R0 resection. The patients’ characteristics, surgical data, and clinicopathological features were used for the analysis of survival and prognostic factors.
Results
The median disease-free survival and median survival time (MST) of all patients were 15 and 30 months, respectively. Only pN3 status (characterized by 7 or more pathologically metastatic lymph nodes) according to the Japanese Classification of Gastric Carcinoma, 14th edition, was shown to be a prognostic factor in a multivariate analysis. The MST of the patients with pN3 and the other patients were 12 and 51 months, respectively (
p
< 0.001).
Conclusions
We suggest that pancreas invasion should not be considered a contraindication for gastrectomy and that patients with a small number of lymph node metastases (six or fewer) might be candidates for GP in the case of gastric cancer that requires pancreatectomy for R0 resection.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-012-1681-2</identifier><identifier>PMID: 22699747</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adult ; Advanced Gastric Cancer ; Aged ; Aged, 80 and over ; Cardiac Surgery ; Distal Pancreatectomy ; Female ; Gastrectomy - methods ; Gastric Cancer ; General Surgery ; Humans ; Male ; Median Survival Time ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Invasiveness ; Pancreatectomy - methods ; Pancreatic Fistula ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Retrospective Studies ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Surgery ; Thoracic Surgery ; Vascular Surgery</subject><ispartof>World journal of surgery, 2012-10, Vol.36 (10), p.2412-2419</ispartof><rights>Société Internationale de Chirurgie 2012</rights><rights>2012 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4224-7c03790c4cd8ff23f408c94399df16de229ec3b0890eb6c8f010f9bf3519a0223</citedby><cites>FETCH-LOGICAL-c4224-7c03790c4cd8ff23f408c94399df16de229ec3b0890eb6c8f010f9bf3519a0223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-012-1681-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-012-1681-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,41467,42536,45553,45554,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22699747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakamoto, Yasuo</creatorcontrib><creatorcontrib>Sakaguchi, Yoshihisa</creatorcontrib><creatorcontrib>Sugiyama, Masahiko</creatorcontrib><creatorcontrib>Minami, Kazuhito</creatorcontrib><creatorcontrib>Toh, Yasushi</creatorcontrib><creatorcontrib>Okamura, Takeshi</creatorcontrib><title>Surgical Indications for Gastrectomy Combined with Distal or Partial Pancreatectomy in Patients with Gastric Cancer</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
The purpose of this study was to clarify the surgical indications for gastrectomy combined with distal or partial pancreatectomy (GP) in patients with gastric cancer.
Methods
From January 1994 to December 2009, 29 patients with primary gastric cancer surgically invading the pancreas without distant organ metastasis underwent GP for R0 resection. The patients’ characteristics, surgical data, and clinicopathological features were used for the analysis of survival and prognostic factors.
Results
The median disease-free survival and median survival time (MST) of all patients were 15 and 30 months, respectively. Only pN3 status (characterized by 7 or more pathologically metastatic lymph nodes) according to the Japanese Classification of Gastric Carcinoma, 14th edition, was shown to be a prognostic factor in a multivariate analysis. The MST of the patients with pN3 and the other patients were 12 and 51 months, respectively (
p
< 0.001).
Conclusions
We suggest that pancreas invasion should not be considered a contraindication for gastrectomy and that patients with a small number of lymph node metastases (six or fewer) might be candidates for GP in the case of gastric cancer that requires pancreatectomy for R0 resection.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Advanced Gastric Cancer</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiac Surgery</subject><subject>Distal Pancreatectomy</subject><subject>Female</subject><subject>Gastrectomy - methods</subject><subject>Gastric Cancer</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Median Survival Time</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Pancreatectomy - methods</subject><subject>Pancreatic Fistula</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Retrospective Studies</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgery</subject><subject>Thoracic Surgery</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkV9LHDEUxUNp0e3WD-CLDPSlL9Pe_NlM8mjXahVBwZY-hkwm0chMRpMMst--2c62iFDMy72E3zkc7kHoEMNnDNB8SQCEixowqTEXuCZv0AIzSmpCCX2LFkA5Kzum--h9SvcAuOHA99A-IVzKhjULlG6meOuN7qvz0JWZ_RhS5cZYnemUozV5HDbVehxaH2xXPfl8V534lIugMNc6Zl_Wax1MtDrvcB_KT_Y25DQr_nh5U60LZ-MH9M7pPtmD3Vyin6fffqy_15dXZ-fr48vaMEJY3RigjQTDTCecI9QxEEYyKmXnMO8sIdIa2oKQYFtuhAMMTraOrrDUQAhdok-z70McHyebshp8MrbvdbDjlBQuT6wEkbigH1-g9-MUQ0mnMAjOBFthWig8UyaOKUXr1EP0g46bAqltI2puRJVG1LYRtQ1xtHOe2sF2_xR_KyiAnIEn39vN647q18XN11PgUE6xRGTWpiILtzY-j_2_RL8Blk-nAw</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Sakamoto, Yasuo</creator><creator>Sakaguchi, Yoshihisa</creator><creator>Sugiyama, Masahiko</creator><creator>Minami, Kazuhito</creator><creator>Toh, Yasushi</creator><creator>Okamura, Takeshi</creator><general>Springer-Verlag</general><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201210</creationdate><title>Surgical Indications for Gastrectomy Combined with Distal or Partial Pancreatectomy in Patients with Gastric Cancer</title><author>Sakamoto, Yasuo ; Sakaguchi, Yoshihisa ; Sugiyama, Masahiko ; Minami, Kazuhito ; Toh, Yasushi ; Okamura, Takeshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4224-7c03790c4cd8ff23f408c94399df16de229ec3b0890eb6c8f010f9bf3519a0223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Advanced Gastric Cancer</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiac Surgery</topic><topic>Distal Pancreatectomy</topic><topic>Female</topic><topic>Gastrectomy - methods</topic><topic>Gastric Cancer</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Median Survival Time</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Pancreatectomy - methods</topic><topic>Pancreatic Fistula</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Retrospective Studies</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgery</topic><topic>Thoracic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakamoto, Yasuo</creatorcontrib><creatorcontrib>Sakaguchi, Yoshihisa</creatorcontrib><creatorcontrib>Sugiyama, Masahiko</creatorcontrib><creatorcontrib>Minami, Kazuhito</creatorcontrib><creatorcontrib>Toh, Yasushi</creatorcontrib><creatorcontrib>Okamura, Takeshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakamoto, Yasuo</au><au>Sakaguchi, Yoshihisa</au><au>Sugiyama, Masahiko</au><au>Minami, Kazuhito</au><au>Toh, Yasushi</au><au>Okamura, Takeshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgical Indications for Gastrectomy Combined with Distal or Partial Pancreatectomy in Patients with Gastric Cancer</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2012-10</date><risdate>2012</risdate><volume>36</volume><issue>10</issue><spage>2412</spage><epage>2419</epage><pages>2412-2419</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background
The purpose of this study was to clarify the surgical indications for gastrectomy combined with distal or partial pancreatectomy (GP) in patients with gastric cancer.
Methods
From January 1994 to December 2009, 29 patients with primary gastric cancer surgically invading the pancreas without distant organ metastasis underwent GP for R0 resection. The patients’ characteristics, surgical data, and clinicopathological features were used for the analysis of survival and prognostic factors.
Results
The median disease-free survival and median survival time (MST) of all patients were 15 and 30 months, respectively. Only pN3 status (characterized by 7 or more pathologically metastatic lymph nodes) according to the Japanese Classification of Gastric Carcinoma, 14th edition, was shown to be a prognostic factor in a multivariate analysis. The MST of the patients with pN3 and the other patients were 12 and 51 months, respectively (
p
< 0.001).
Conclusions
We suggest that pancreas invasion should not be considered a contraindication for gastrectomy and that patients with a small number of lymph node metastases (six or fewer) might be candidates for GP in the case of gastric cancer that requires pancreatectomy for R0 resection.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22699747</pmid><doi>10.1007/s00268-012-1681-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Abdominal Surgery Adult Advanced Gastric Cancer Aged Aged, 80 and over Cardiac Surgery Distal Pancreatectomy Female Gastrectomy - methods Gastric Cancer General Surgery Humans Male Median Survival Time Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness Pancreatectomy - methods Pancreatic Fistula Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Retrospective Studies Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgery Thoracic Surgery Vascular Surgery |
| title | Surgical Indications for Gastrectomy Combined with Distal or Partial Pancreatectomy in Patients with Gastric Cancer |
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