Spending functions and continuous-monitoring boundaries

Clinical trials are monitored periodically for safety, efficacy, and futility. The spending function is a popular tool for efficacy monitoring because it does not require pre‐specification of the number or timing of interim analyses. But there are infinitely many spending functions, so some guidance...

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Veröffentlicht in:	Statistics in medicine 2012-11, Vol.31 (25), p.3024-3030
Hauptverfasser:	Proschan, Michael A., Gordon Lan, K. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	B-value boundaries Brownian motion Clinical trials Clinical Trials as Topic - statistics & numerical data Data Interpretation, Statistical Design of experiments group-sequential monitoring information fraction interim analyses Mathematical functions Models, Statistical Patient Safety - statistics & numerical data power spending functions
Online-Zugang:	Volltext
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