Molecular Mechanism of ATP Hydrolysis in F1-ATPase Revealed by Molecular Simulations and Single-Molecule Observations

Enzymatic hydrolysis of nucleotide triphosphate (NTP) plays a pivotal role in protein functions. In spite of its biological significance, however, the chemistry of the hydrolysis catalysis remains obscure because of the complex nature of the reaction. Here we report a study of the molecular mechanis...

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Veröffentlicht in:	Journal of the American Chemical Society 2012-05, Vol.134 (20), p.8447-8454
Hauptverfasser:	Hayashi, Shigehiko, Ueno, Hiroshi, Shaikh, Abdul Rajjak, Umemura, Myco, Kamiya, Motoshi, Ito, Yuko, Ikeguchi, Mitsunori, Komoriya, Yoshihito, Iino, Ryota, Noji, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Animals Cattle Hydrolysis Molecular Dynamics Simulation Mutation Proton-Translocating ATPases - chemistry Proton-Translocating ATPases - genetics Proton-Translocating ATPases - metabolism Thermodynamics
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