Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism

Summary Over the past two decades, structural biology has shown how T‐cell receptors engage peptide/major histocompatibility complex (MHC) complexes and provided insight into the mechanisms underlying antigen specificity and cross‐reactivity. Here we review and contextualize our contributions, which...

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Veröffentlicht in:	Immunological reviews 2012-11, Vol.250 (1), p.10-31
Hauptverfasser:	Baker, Brian M., Scott, Daniel R., Blevins, Sydney J., Hawse, William F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - chemistry Antigens - immunology Antigens - metabolism Binding Sites Cross Reactions cross-reactivity Humans Lymphocyte Activation Major Histocompatibility Complex - immunology MHC Mice Models, Molecular molecular flexibility Peptides - chemistry Peptides - immunology Peptides - metabolism Protein Binding Protein Conformation Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism specificity structure T-Cell Antigen Receptor Specificity T-cell receptor T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism
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