Type 1 Diabetes: Current Concepts in Epidemiology, Pathophysiology, Clinical Care, and Research
Type 1 diabetes (T1D) is an autoimmune disease mediated by a combination of genetic and environmental triggers resulting in lymphocytic infiltration of pancreatic islets, destruction of beta cells, and lifelong dependency on exogenous insulin. Although T1D is prevalent (1 in 300) and its incidence i...
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| Veröffentlicht in: | Current problems in pediatric and adolescent health care 2012-11, Vol.42 (10), p.269-291 |
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| container_title | Current problems in pediatric and adolescent health care |
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| creator | Gan, Mary Joyce, MD Albanese-O’Neill, Anastasia, RN, CDE Haller, Michael J., MD |
| description | Type 1 diabetes (T1D) is an autoimmune disease mediated by a combination of genetic and environmental triggers resulting in lymphocytic infiltration of pancreatic islets, destruction of beta cells, and lifelong dependency on exogenous insulin. Although T1D is prevalent (1 in 300) and its incidence is steadily increasing worldwide (3% per year), the exact gene-environment interactions precipitating the disease remain unknown. Living with T1D is challenging for patients, families, and caregivers. Because of the relative paucity of pediatric endocrinologists, general pediatricians and other subspecialists may occasionally be faced with the task of managing diabetes-related complaints. Herein, we provide a comprehensive review of the natural history, pathophysiology, and contemporary management of T1D. In addition, recent advances in T1D research are discussed. |
| doi_str_mv | 10.1016/j.cppeds.2012.07.002 |
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Although T1D is prevalent (1 in 300) and its incidence is steadily increasing worldwide (3% per year), the exact gene-environment interactions precipitating the disease remain unknown. Living with T1D is challenging for patients, families, and caregivers. Because of the relative paucity of pediatric endocrinologists, general pediatricians and other subspecialists may occasionally be faced with the task of managing diabetes-related complaints. Herein, we provide a comprehensive review of the natural history, pathophysiology, and contemporary management of T1D. 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Although T1D is prevalent (1 in 300) and its incidence is steadily increasing worldwide (3% per year), the exact gene-environment interactions precipitating the disease remain unknown. Living with T1D is challenging for patients, families, and caregivers. Because of the relative paucity of pediatric endocrinologists, general pediatricians and other subspecialists may occasionally be faced with the task of managing diabetes-related complaints. Herein, we provide a comprehensive review of the natural history, pathophysiology, and contemporary management of T1D. In addition, recent advances in T1D research are discussed.</description><subject>Age Factors</subject><subject>Autoantibodies - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Child</subject><subject>Clinical Trials as Topic</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - diagnosis</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes Mellitus, Type 1 - therapy</subject><subject>Diabetic Ketoacidosis - blood</subject><subject>Diabetic Ketoacidosis - diagnosis</subject><subject>Diabetic Ketoacidosis - therapy</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Global Health</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Hypoglycemia - chemically induced</subject><subject>Hypoglycemia - prevention & control</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Incidence</subject><subject>Insulin - administration & dosage</subject><subject>Insulin - adverse effects</subject><subject>Interdisciplinary Communication</subject><subject>Life Style</subject><subject>Obesity - complications</subject><subject>Patient Care Team</subject><subject>Patient Education as Topic</subject><subject>Pediatrics</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>United States - epidemiology</subject><issn>1538-5442</issn><issn>1538-3199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAQgC1ERduFf4CQjxy6YfzIiwMSCi1UqlQE5Ww59oT1ko2DnSDl3-Notxy4VLI01uibGc03hLxmkDFgxbt9ZsYRbcw4MJ5BmQHwZ-SC5aLaClbXz0__XEp-Ti5j3CdAABMvyHmKsigFvyDqYRmRMvrJ6RYnjO9pM4eAw0QbPxgcp0jdQK9HZ_HgfO9_Llf0q552ftwt8THR9G5wRve00QGvqB4s_YYRdTC7l-Ss033EV6e4IT9urh-aL9u7-8-3zce7rZGsnLal1iBt27VF2aVXtkKAgDK3kNeaS1kwWXALtm1FZzjniLLTRQ2ga41QCbEhb499x-B_zxgndXDRYN_rAf0cFYM6r7ioqiKh8oia4GMM2KkxuIMOS4LUqlbt1VGtWtUqKNVqbkPenCbM7QHtv6JHlwn4cAQw7fnHYVDROEwSrQtoJmW9e2rC_w3MSewvXDDu_RyG5FAxFVON-r6ed70u4wCMyVr8Be1yn_s</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Gan, Mary Joyce, MD</creator><creator>Albanese-O’Neill, Anastasia, RN, CDE</creator><creator>Haller, Michael J., MD</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>Type 1 Diabetes: Current Concepts in Epidemiology, Pathophysiology, Clinical Care, and Research</title><author>Gan, Mary Joyce, MD ; Albanese-O’Neill, Anastasia, RN, CDE ; Haller, Michael J., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7aa04dbfb67f67f7b3303075d059a24461462d0dbb3fc222ee4fa6900a9ae0833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Factors</topic><topic>Autoantibodies - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Child</topic><topic>Clinical Trials as Topic</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - diagnosis</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes Mellitus, Type 1 - therapy</topic><topic>Diabetic Ketoacidosis - blood</topic><topic>Diabetic Ketoacidosis - diagnosis</topic><topic>Diabetic Ketoacidosis - therapy</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Global Health</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Hypoglycemia - chemically induced</topic><topic>Hypoglycemia - prevention & control</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Incidence</topic><topic>Insulin - administration & dosage</topic><topic>Insulin - adverse effects</topic><topic>Interdisciplinary Communication</topic><topic>Life Style</topic><topic>Obesity - complications</topic><topic>Patient Care Team</topic><topic>Patient Education as Topic</topic><topic>Pediatrics</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gan, Mary Joyce, MD</creatorcontrib><creatorcontrib>Albanese-O’Neill, Anastasia, RN, CDE</creatorcontrib><creatorcontrib>Haller, Michael J., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current problems in pediatric and adolescent health care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gan, Mary Joyce, MD</au><au>Albanese-O’Neill, Anastasia, RN, CDE</au><au>Haller, Michael J., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type 1 Diabetes: Current Concepts in Epidemiology, Pathophysiology, Clinical Care, and Research</atitle><jtitle>Current problems in pediatric and adolescent health care</jtitle><addtitle>Curr Probl Pediatr Adolesc Health Care</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>42</volume><issue>10</issue><spage>269</spage><epage>291</epage><pages>269-291</pages><issn>1538-5442</issn><eissn>1538-3199</eissn><abstract>Type 1 diabetes (T1D) is an autoimmune disease mediated by a combination of genetic and environmental triggers resulting in lymphocytic infiltration of pancreatic islets, destruction of beta cells, and lifelong dependency on exogenous insulin. Although T1D is prevalent (1 in 300) and its incidence is steadily increasing worldwide (3% per year), the exact gene-environment interactions precipitating the disease remain unknown. Living with T1D is challenging for patients, families, and caregivers. Because of the relative paucity of pediatric endocrinologists, general pediatricians and other subspecialists may occasionally be faced with the task of managing diabetes-related complaints. Herein, we provide a comprehensive review of the natural history, pathophysiology, and contemporary management of T1D. In addition, recent advances in T1D research are discussed.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>23046732</pmid><doi>10.1016/j.cppeds.2012.07.002</doi><tpages>23</tpages></addata></record> |
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| subjects | Age Factors Autoantibodies - blood Blood Glucose - metabolism Child Clinical Trials as Topic Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 1 - therapy Diabetic Ketoacidosis - blood Diabetic Ketoacidosis - diagnosis Diabetic Ketoacidosis - therapy Female Genetic Predisposition to Disease Global Health Glycated Hemoglobin A - metabolism Humans Hypoglycemia - chemically induced Hypoglycemia - prevention & control Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Incidence Insulin - administration & dosage Insulin - adverse effects Interdisciplinary Communication Life Style Obesity - complications Patient Care Team Patient Education as Topic Pediatrics Prevalence Prognosis Risk Factors United States - epidemiology |
| title | Type 1 Diabetes: Current Concepts in Epidemiology, Pathophysiology, Clinical Care, and Research |
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