A hypoallergenic variant of the major birch pollen allergen shows distinct characteristics in antigen processing and T-cell activation

Background BM4 is a novel genetically engineered variant of the major birch pollen allergen Bet v 1 that lacks the typical Bet v 1‐like fold and displays negligible IgE‐binding but strong T cell–activating capacity. The aim of this study was to elucidate possible differences between BM4 and Bet v 1...

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Veröffentlicht in:	Allergy (Copenhagen) 2012-11, Vol.67 (11), p.1375-1382
Hauptverfasser:	Kitzmüller, C., Wallner, M., Deifl, S., Mutschlechner, S., Walterskirchen, C., Zlabinger, G. J., Ferreira, F., Bohle, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	allergen-specific immunotherapy Allergens - immunology Allergies Amino Acid Sequence Antigen Presentation Antigens, Plant - chemistry Antigens, Plant - immunology Antigens, Plant - metabolism Bet v 1 Betula - immunology Biological and medical sciences Cell Polarity Dermatology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans hypoallergen Immunology Immunotherapy Lymphocyte Activation Medical sciences Molecular Sequence Data Pollen Pollen - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis T-cell modulation T-Lymphocytes - immunology
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