Dose-Response Effects of Diphenylhydantoin on Pregnant Dams and Embryo-Fetal Development in Rats

Despite the widespread use of diphenylhydantoin (DPH), there is a lack of reliable information on the teratogenic effects, correlation with maternal and developmental toxicity, and dose–response relationship of DPH. This study investigated the dose–response effects of DPH on pregnant dams and embryo...

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Veröffentlicht in:	Birth defects research. Part B. Developmental and reproductive toxicology 2012-10, Vol.95 (5), p.337-345
Hauptverfasser:	Kim, Sung-Hwan, Lee, In-Chul, Baek, Hyung-Seon, Lim, Jeong-Hyeon, Moon, Changjong, Shin, Dong-Ho, Kim, Sung-Ho, Park, Seung-Chun, Kim, Jong-Choon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Animals Body Weight - drug effects Bone and Bones - abnormalities Bone and Bones - drug effects Bone and Bones - pathology Cesarean Section developmental toxicity diphenylhydantoin dose-response relationship Dose-Response Relationship, Drug Embryonic Development - drug effects Endocrine system Female Fetus - drug effects Fetus - embryology Male maternal toxicity Organ Size - drug effects Phenytoin - toxicity Pregnancy Rats Rodents teratogenicity Viscera - drug effects
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