Dipeptidyl Peptidase-4 Modulates Left Ventricular Dysfunction in Chronic Heart Failure via Angiogenesis-Dependent and -Independent Actions

The inhibition of dipeptidyl peptidase-4 (DPP4) protects the heart from acute myocardial ischemia. However, the role of DPP4 in chronic heart failure independent of coronary artery disease remains unclear. We first localized the membrane-bound form of DPP4 to the capillary endothelia of rat and huma...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2012-10, Vol.126 (15), p.1838-1851
Hauptverfasser:	SHIGETA, Toshimasa, AOYAMA, Morihiko, MUROHARA, Toyoaki, BANDO, Yasuko K, MONJI, Akio, MITSUI, Toko, TAKATSU, Miwa, CHENG, Xiang-Wu, OKUMURA, Takahiro, HIRASHIKI, Akihiro, NAGATA, Kohzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Chronic Disease Diabetes Complications - metabolism Diabetes Complications - physiopathology Diastole Dipeptidyl Peptidase 4 - blood Dipeptidyl Peptidase 4 - metabolism Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Heart Failure - metabolism Heart Failure - physiopathology Humans Male Medical sciences Miscellaneous Neovascularization, Pathologic - physiopathology Pharmacology. Drug treatments Rats Rats, Inbred Strains Ventricular Dysfunction, Left - metabolism Ventricular Dysfunction, Left - physiopathology
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