The mediation of the central histaminergic system in the pressor effect of intracerebroventricularly injected melittin, a phospholipase A2 activator, in normotensive rats

Abstract Melittin is a polypeptide component of bee venom that leads to an increase in arachidonic acid release and subsequently in prostaglandin synthesis by activating phospholipase A2 . Recently we demonstrated that centrally or peripherally administrated melittin caused pressor effect and centra...

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Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2012-10, Vol.87 (4), p.153-158
Hauptverfasser:	Altinbas, Burcin, Topuz, Bora B, Yilmaz, Mustafa S, Aydin, Cenk, Savci, Vahide, Jochem, Jerzy, Aydin, Sami, Yalcin, Murat
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Arterial Pressure - drug effects Brain phospholipase A2 Central histaminergic system Endocrinology & Metabolism Heart rate Injections, Intraventricular Intracerebroventricular Male Mean arterial pressure Melitten - administration & dosage Melitten - pharmacology Melittin Microdialysis Phospholipases A2 - metabolism Rats Rats, Sprague-Dawley
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