Femoral-gluteal adiposity is not associated with insulin sensitivity in Type 1 diabetes

Aims To quantify and compare associations between femoral–gluteal adiposity and insulin sensitivity in adults with Type 1 diabetes mellitus with adults with normal glucose tolerance. Methods Individuals with Type 1 diabetes (n = 28) were recruited from the Pittsburgh Epidemiology of Diabetes Complication study, a 24‐year prospective study of childhood‐onset diabetes, and compared cross‐sectionally with individuals with normal glucose tolerance (n = 56) of similar age, sex and BMI. Insulin sensitivity was defined as whole‐body glucose disposal measured by hyperinsulinaemic–euglycaemic clamps. Adiposity was quantified by dual energy X‐ray absorptiometry. Results Individuals with Type 1 diabetes exhibited lower insulin sensitivity (5.8 vs. 8.2 mg min−1 kg fat‐free mass−1, P