Patterns of Peripapillary Retinal Nerve Fiber Layer Thinning in Vigabatrin-Exposed Individuals
Purpose To explore the relationship of peripapillary retinal nerve fiber layer (ppRNFL) thinning in individuals exposed to the antiepileptic drug vigabatrin with respect to 2 separate variables: cumulative vigabatrin exposure and severity of vigabatrin-associated visual field loss (VAVFL). Design Cr...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 2012-10, Vol.119 (10), p.2152-2160 |
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| creator | Clayton, Lisa M., PhD Devile, Marita Punte, Trusjen de Haan, Gerrit-Jan, MD, PhD Sander, Josemir W., MD, PhD Acheson, James F., MD Sisodiya, Sanjay M., MD, PhD |
| description | Purpose To explore the relationship of peripapillary retinal nerve fiber layer (ppRNFL) thinning in individuals exposed to the antiepileptic drug vigabatrin with respect to 2 separate variables: cumulative vigabatrin exposure and severity of vigabatrin-associated visual field loss (VAVFL). Design Cross-sectional observational study. Participants Subjects were older than 18 years, 129 with vigabatrin-treated epilepsy (vigabatrin-exposed group) and 87 individuals with epilepsy never treated with vigabatrin (nonexposed group). Methods All subjects underwent ppRNFL imaging using spectral-domain optical coherence tomography. Eighty-four vigabatrin-exposed individuals underwent Goldmann kinetic perimetry. The visual field examined from the right eye was categorized as normal (n = 47), mildly abnormal (n = 18), or moderately to severely abnormal (n = 19). In 91 vigabatrin-exposed individuals, the cumulative vigabatrin exposure could be ascertained: 41 subjects received 1000 g or less, 23 subjects received more than 1000 g but equal to or less than 2500 g, 16 subjects received more than 2500 g but equal to or less than 5000 g or less, and 11 subjects received more than 5000 g. Main Outcome Measures Differences in ppRNFL thickness across the twelve 30° sectors: (1) among all nonexposed individuals and all vigabatrin-exposed individuals, (2) between each vigabatrin-exposed group, according to cumulative vigabatrin exposure, and the nonexposed group, (3) among different vigabatrin-exposed subjects grouped according to cumulative vigabatrin exposure, and (4) among vigabatrin-exposed subjects grouped according to severity of VAVFL. Results The ppRNFL was significantly thinner in vigabatrin-exposed compared with nonexposed individuals in most 30° sectors ( P |
| doi_str_mv | 10.1016/j.ophtha.2012.05.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1093560706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0161642012004149</els_id><sourcerecordid>1093560706</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-e436fc9a32db5f37c3ac2b440da3fd454fe0a7e91abddba06adacba6cb0b78a83</originalsourceid><addsrcrecordid>eNqFkk9vEzEQxS0EomnhGyC0FyQuG8Zr778LEqpaqBRBBYUj1tiebRw23sXejci3r6MEkLhw8Vx-b8bvzTD2gsOSA6_ebJbDuJ7WuCyAF0solwDtI7bgpWxzWXPxmC0SxvNKFnDGzmPcAEBVCfmUnRVFU4q2Fgv2_RaniYKP2dBltxTciKPrewz77DNNzmOffaSwo-zaaQrZCvfpvVs7752_z5zPvrl71DgF5_OrX-MQyWY33rqdszP28Rl70qVCz0_1gn29vrq7_JCvPr2_uXy3yo2U9ZSTFFVnWhSF1WUnaiPQFFpKsCg6K0vZEWBNLUdtrUao0KLRWBkNum6wERfs9bHvGIafM8VJbV00lIx4GuaoOLSirKCGKqHyiJowxBioU2Nw22Q4QeqQrNqoY7LqkKyCUqVkk-zlacKst2T_iH5HmYBXJwCjwb4L6I2Lf7mq4U0NReLeHjlKeewcBRWNI2_IukBmUnZw__vJvw1M77xLM3_QnuJmmENaW_KsYtKoL4crOBwBLwAkl614APY4r6o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1093560706</pqid></control><display><type>article</type><title>Patterns of Peripapillary Retinal Nerve Fiber Layer Thinning in Vigabatrin-Exposed Individuals</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Clayton, Lisa M., PhD ; Devile, Marita ; Punte, Trusjen ; de Haan, Gerrit-Jan, MD, PhD ; Sander, Josemir W., MD, PhD ; Acheson, James F., MD ; Sisodiya, Sanjay M., MD, PhD</creator><creatorcontrib>Clayton, Lisa M., PhD ; Devile, Marita ; Punte, Trusjen ; de Haan, Gerrit-Jan, MD, PhD ; Sander, Josemir W., MD, PhD ; Acheson, James F., MD ; Sisodiya, Sanjay M., MD, PhD</creatorcontrib><description>Purpose To explore the relationship of peripapillary retinal nerve fiber layer (ppRNFL) thinning in individuals exposed to the antiepileptic drug vigabatrin with respect to 2 separate variables: cumulative vigabatrin exposure and severity of vigabatrin-associated visual field loss (VAVFL). Design Cross-sectional observational study. Participants Subjects were older than 18 years, 129 with vigabatrin-treated epilepsy (vigabatrin-exposed group) and 87 individuals with epilepsy never treated with vigabatrin (nonexposed group). Methods All subjects underwent ppRNFL imaging using spectral-domain optical coherence tomography. Eighty-four vigabatrin-exposed individuals underwent Goldmann kinetic perimetry. The visual field examined from the right eye was categorized as normal (n = 47), mildly abnormal (n = 18), or moderately to severely abnormal (n = 19). In 91 vigabatrin-exposed individuals, the cumulative vigabatrin exposure could be ascertained: 41 subjects received 1000 g or less, 23 subjects received more than 1000 g but equal to or less than 2500 g, 16 subjects received more than 2500 g but equal to or less than 5000 g or less, and 11 subjects received more than 5000 g. Main Outcome Measures Differences in ppRNFL thickness across the twelve 30° sectors: (1) among all nonexposed individuals and all vigabatrin-exposed individuals, (2) between each vigabatrin-exposed group, according to cumulative vigabatrin exposure, and the nonexposed group, (3) among different vigabatrin-exposed subjects grouped according to cumulative vigabatrin exposure, and (4) among vigabatrin-exposed subjects grouped according to severity of VAVFL. Results The ppRNFL was significantly thinner in vigabatrin-exposed compared with nonexposed individuals in most 30° sectors ( P <0.004). The temporal, temporal superior, and temporal inferior 30° sectors, as well as the nasal 30° sector, were not affected. There was a trend for increasing ppRNFL thinning with increasing cumulative vigabatrin exposure. The nasal-superior 30° sector was significantly thinner in group 1 (≤1000 g) compared with nonexposed individuals ( P <0.05) and in vigabatrin-exposed individuals with normal visual fields compared with nonexposed individuals ( P <0.05). Conclusions After vigabatrin exposure in individuals receiving cumulative doses of 1000 g or less or in the presence of normal visual fields, ppRNFL thinning in the nasal superior 30° sector may occur. With higher cumulative doses of vigabatrin exposure, additional ppRNFL thinning was observed. The temporal aspects of the ppRNFL are spared, even in individuals with large cumulative vigabatrin exposures and moderate or severe VAVFL. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/j.ophtha.2012.05.009</identifier><identifier>PMID: 22853973</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Anticonvulsants - adverse effects ; Biological and medical sciences ; Cross-Sectional Studies ; Epilepsy - drug therapy ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Nerve Fibers - drug effects ; Nerve Fibers - pathology ; Ophthalmology ; Optic Disk - drug effects ; Optic Disk - pathology ; Optic Nerve Diseases - chemically induced ; Optic Nerve Diseases - diagnosis ; Retinal Ganglion Cells - drug effects ; Retinal Ganglion Cells - pathology ; Tomography, Optical Coherence ; Vigabatrin - adverse effects ; Vision Disorders - chemically induced ; Vision Disorders - diagnosis ; Visual Field Tests ; Visual Fields</subject><ispartof>Ophthalmology (Rochester, Minn.), 2012-10, Vol.119 (10), p.2152-2160</ispartof><rights>American Academy of Ophthalmology</rights><rights>2012 American Academy of Ophthalmology</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-e436fc9a32db5f37c3ac2b440da3fd454fe0a7e91abddba06adacba6cb0b78a83</citedby><cites>FETCH-LOGICAL-c447t-e436fc9a32db5f37c3ac2b440da3fd454fe0a7e91abddba06adacba6cb0b78a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ophtha.2012.05.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26818702$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22853973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clayton, Lisa M., PhD</creatorcontrib><creatorcontrib>Devile, Marita</creatorcontrib><creatorcontrib>Punte, Trusjen</creatorcontrib><creatorcontrib>de Haan, Gerrit-Jan, MD, PhD</creatorcontrib><creatorcontrib>Sander, Josemir W., MD, PhD</creatorcontrib><creatorcontrib>Acheson, James F., MD</creatorcontrib><creatorcontrib>Sisodiya, Sanjay M., MD, PhD</creatorcontrib><title>Patterns of Peripapillary Retinal Nerve Fiber Layer Thinning in Vigabatrin-Exposed Individuals</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>Purpose To explore the relationship of peripapillary retinal nerve fiber layer (ppRNFL) thinning in individuals exposed to the antiepileptic drug vigabatrin with respect to 2 separate variables: cumulative vigabatrin exposure and severity of vigabatrin-associated visual field loss (VAVFL). Design Cross-sectional observational study. Participants Subjects were older than 18 years, 129 with vigabatrin-treated epilepsy (vigabatrin-exposed group) and 87 individuals with epilepsy never treated with vigabatrin (nonexposed group). Methods All subjects underwent ppRNFL imaging using spectral-domain optical coherence tomography. Eighty-four vigabatrin-exposed individuals underwent Goldmann kinetic perimetry. The visual field examined from the right eye was categorized as normal (n = 47), mildly abnormal (n = 18), or moderately to severely abnormal (n = 19). In 91 vigabatrin-exposed individuals, the cumulative vigabatrin exposure could be ascertained: 41 subjects received 1000 g or less, 23 subjects received more than 1000 g but equal to or less than 2500 g, 16 subjects received more than 2500 g but equal to or less than 5000 g or less, and 11 subjects received more than 5000 g. Main Outcome Measures Differences in ppRNFL thickness across the twelve 30° sectors: (1) among all nonexposed individuals and all vigabatrin-exposed individuals, (2) between each vigabatrin-exposed group, according to cumulative vigabatrin exposure, and the nonexposed group, (3) among different vigabatrin-exposed subjects grouped according to cumulative vigabatrin exposure, and (4) among vigabatrin-exposed subjects grouped according to severity of VAVFL. Results The ppRNFL was significantly thinner in vigabatrin-exposed compared with nonexposed individuals in most 30° sectors ( P <0.004). The temporal, temporal superior, and temporal inferior 30° sectors, as well as the nasal 30° sector, were not affected. There was a trend for increasing ppRNFL thinning with increasing cumulative vigabatrin exposure. The nasal-superior 30° sector was significantly thinner in group 1 (≤1000 g) compared with nonexposed individuals ( P <0.05) and in vigabatrin-exposed individuals with normal visual fields compared with nonexposed individuals ( P <0.05). Conclusions After vigabatrin exposure in individuals receiving cumulative doses of 1000 g or less or in the presence of normal visual fields, ppRNFL thinning in the nasal superior 30° sector may occur. With higher cumulative doses of vigabatrin exposure, additional ppRNFL thinning was observed. The temporal aspects of the ppRNFL are spared, even in individuals with large cumulative vigabatrin exposures and moderate or severe VAVFL. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.</description><subject>Adult</subject><subject>Anticonvulsants - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Epilepsy - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Nerve Fibers - drug effects</subject><subject>Nerve Fibers - pathology</subject><subject>Ophthalmology</subject><subject>Optic Disk - drug effects</subject><subject>Optic Disk - pathology</subject><subject>Optic Nerve Diseases - chemically induced</subject><subject>Optic Nerve Diseases - diagnosis</subject><subject>Retinal Ganglion Cells - drug effects</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Tomography, Optical Coherence</subject><subject>Vigabatrin - adverse effects</subject><subject>Vision Disorders - chemically induced</subject><subject>Vision Disorders - diagnosis</subject><subject>Visual Field Tests</subject><subject>Visual Fields</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9vEzEQxS0EomnhGyC0FyQuG8Zr778LEqpaqBRBBYUj1tiebRw23sXejci3r6MEkLhw8Vx-b8bvzTD2gsOSA6_ebJbDuJ7WuCyAF0solwDtI7bgpWxzWXPxmC0SxvNKFnDGzmPcAEBVCfmUnRVFU4q2Fgv2_RaniYKP2dBltxTciKPrewz77DNNzmOffaSwo-zaaQrZCvfpvVs7752_z5zPvrl71DgF5_OrX-MQyWY33rqdszP28Rl70qVCz0_1gn29vrq7_JCvPr2_uXy3yo2U9ZSTFFVnWhSF1WUnaiPQFFpKsCg6K0vZEWBNLUdtrUao0KLRWBkNum6wERfs9bHvGIafM8VJbV00lIx4GuaoOLSirKCGKqHyiJowxBioU2Nw22Q4QeqQrNqoY7LqkKyCUqVkk-zlacKst2T_iH5HmYBXJwCjwb4L6I2Lf7mq4U0NReLeHjlKeewcBRWNI2_IukBmUnZw__vJvw1M77xLM3_QnuJmmENaW_KsYtKoL4crOBwBLwAkl614APY4r6o</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Clayton, Lisa M., PhD</creator><creator>Devile, Marita</creator><creator>Punte, Trusjen</creator><creator>de Haan, Gerrit-Jan, MD, PhD</creator><creator>Sander, Josemir W., MD, PhD</creator><creator>Acheson, James F., MD</creator><creator>Sisodiya, Sanjay M., MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Patterns of Peripapillary Retinal Nerve Fiber Layer Thinning in Vigabatrin-Exposed Individuals</title><author>Clayton, Lisa M., PhD ; Devile, Marita ; Punte, Trusjen ; de Haan, Gerrit-Jan, MD, PhD ; Sander, Josemir W., MD, PhD ; Acheson, James F., MD ; Sisodiya, Sanjay M., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-e436fc9a32db5f37c3ac2b440da3fd454fe0a7e91abddba06adacba6cb0b78a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Anticonvulsants - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Epilepsy - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Nerve Fibers - drug effects</topic><topic>Nerve Fibers - pathology</topic><topic>Ophthalmology</topic><topic>Optic Disk - drug effects</topic><topic>Optic Disk - pathology</topic><topic>Optic Nerve Diseases - chemically induced</topic><topic>Optic Nerve Diseases - diagnosis</topic><topic>Retinal Ganglion Cells - drug effects</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Tomography, Optical Coherence</topic><topic>Vigabatrin - adverse effects</topic><topic>Vision Disorders - chemically induced</topic><topic>Vision Disorders - diagnosis</topic><topic>Visual Field Tests</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clayton, Lisa M., PhD</creatorcontrib><creatorcontrib>Devile, Marita</creatorcontrib><creatorcontrib>Punte, Trusjen</creatorcontrib><creatorcontrib>de Haan, Gerrit-Jan, MD, PhD</creatorcontrib><creatorcontrib>Sander, Josemir W., MD, PhD</creatorcontrib><creatorcontrib>Acheson, James F., MD</creatorcontrib><creatorcontrib>Sisodiya, Sanjay M., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clayton, Lisa M., PhD</au><au>Devile, Marita</au><au>Punte, Trusjen</au><au>de Haan, Gerrit-Jan, MD, PhD</au><au>Sander, Josemir W., MD, PhD</au><au>Acheson, James F., MD</au><au>Sisodiya, Sanjay M., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of Peripapillary Retinal Nerve Fiber Layer Thinning in Vigabatrin-Exposed Individuals</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>119</volume><issue>10</issue><spage>2152</spage><epage>2160</epage><pages>2152-2160</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>Purpose To explore the relationship of peripapillary retinal nerve fiber layer (ppRNFL) thinning in individuals exposed to the antiepileptic drug vigabatrin with respect to 2 separate variables: cumulative vigabatrin exposure and severity of vigabatrin-associated visual field loss (VAVFL). Design Cross-sectional observational study. Participants Subjects were older than 18 years, 129 with vigabatrin-treated epilepsy (vigabatrin-exposed group) and 87 individuals with epilepsy never treated with vigabatrin (nonexposed group). Methods All subjects underwent ppRNFL imaging using spectral-domain optical coherence tomography. Eighty-four vigabatrin-exposed individuals underwent Goldmann kinetic perimetry. The visual field examined from the right eye was categorized as normal (n = 47), mildly abnormal (n = 18), or moderately to severely abnormal (n = 19). In 91 vigabatrin-exposed individuals, the cumulative vigabatrin exposure could be ascertained: 41 subjects received 1000 g or less, 23 subjects received more than 1000 g but equal to or less than 2500 g, 16 subjects received more than 2500 g but equal to or less than 5000 g or less, and 11 subjects received more than 5000 g. Main Outcome Measures Differences in ppRNFL thickness across the twelve 30° sectors: (1) among all nonexposed individuals and all vigabatrin-exposed individuals, (2) between each vigabatrin-exposed group, according to cumulative vigabatrin exposure, and the nonexposed group, (3) among different vigabatrin-exposed subjects grouped according to cumulative vigabatrin exposure, and (4) among vigabatrin-exposed subjects grouped according to severity of VAVFL. Results The ppRNFL was significantly thinner in vigabatrin-exposed compared with nonexposed individuals in most 30° sectors ( P <0.004). The temporal, temporal superior, and temporal inferior 30° sectors, as well as the nasal 30° sector, were not affected. There was a trend for increasing ppRNFL thinning with increasing cumulative vigabatrin exposure. The nasal-superior 30° sector was significantly thinner in group 1 (≤1000 g) compared with nonexposed individuals ( P <0.05) and in vigabatrin-exposed individuals with normal visual fields compared with nonexposed individuals ( P <0.05). Conclusions After vigabatrin exposure in individuals receiving cumulative doses of 1000 g or less or in the presence of normal visual fields, ppRNFL thinning in the nasal superior 30° sector may occur. With higher cumulative doses of vigabatrin exposure, additional ppRNFL thinning was observed. The temporal aspects of the ppRNFL are spared, even in individuals with large cumulative vigabatrin exposures and moderate or severe VAVFL. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22853973</pmid><doi>10.1016/j.ophtha.2012.05.009</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Anticonvulsants - adverse effects Biological and medical sciences Cross-Sectional Studies Epilepsy - drug therapy Female Humans Male Medical sciences Middle Aged Miscellaneous Nerve Fibers - drug effects Nerve Fibers - pathology Ophthalmology Optic Disk - drug effects Optic Disk - pathology Optic Nerve Diseases - chemically induced Optic Nerve Diseases - diagnosis Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - pathology Tomography, Optical Coherence Vigabatrin - adverse effects Vision Disorders - chemically induced Vision Disorders - diagnosis Visual Field Tests Visual Fields |
| title | Patterns of Peripapillary Retinal Nerve Fiber Layer Thinning in Vigabatrin-Exposed Individuals |
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