One-step (18)F-labeling of peptides for positron emission tomography imaging using the SiFA methodology

Here we present a procedure to label peptides with the positron-emitting radioisotope fluorine-18 ((18)F) using the silicon-fluoride acceptor (SiFA) labeling methodology. Positron emission tomography (PET) has gained high importance in noninvasive imaging of various diseases over the past decades, a...

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Veröffentlicht in:	Nature protocols 2012-11, Vol.7 (11), p.1946-1955
Hauptverfasser:	Wängler, Carmen, Niedermoser, Sabrina, Chin, Joshua, Orchowski, Katy, Schirrmacher, Esther, Jurkschat, Klaus, Iovkova-Berends, Liuba, Kostikov, Alexey P, Schirrmacher, Ralf, Wängler, Björn
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid Diagnostic imaging Fluorine Radioisotopes Isotope Labeling - methods Labeling Methods Organosilicon Compounds - analysis Organosilicon Compounds - chemistry Peptides Peptides - analysis Peptides - chemistry PET imaging Positron-Emission Tomography - methods Temperature
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