Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis

Natural killer (NK) cells play a role in the early control and natural course of hepatitis C virus (HCV) infection. NK cell function is regulated by a multitude of receptors, including activating NKp46 receptor. However, reports on NKp46 in hepatitis C are controversial. Therefore, we investigated t...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2012-10, Vol.56 (4), p.1201-1213
Hauptverfasser:	Krämer, Benjamin, Körner, Christian, Kebschull, Moritz, Glässner, Andreas, Eisenhardt, Marianne, Nischalke, Hans-Dieter, Alexander, Michael, Sauerbruch, Tilman, Spengler, Ulrich, Nattermann, Jacob
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Biopsy, Needle Case-Control Studies Cells, Cultured Cytotoxicity, Immunologic - genetics Cytotoxicity, Immunologic - immunology Disease Progression Fatty Liver - genetics Fatty Liver - immunology Fatty Liver - physiopathology Female Flow Cytometry Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Viral Hepacivirus - immunology Hepacivirus - pathogenicity Hepatic Stellate Cells - immunology Hepatic Stellate Cells - physiology Hepatitis Hepatitis C Hepatitis C, Chronic - genetics Hepatitis C, Chronic - immunology Hepatitis C, Chronic - physiopathology Hepatitis, Autoimmune - genetics Hepatitis, Autoimmune - immunology Hepatitis, Autoimmune - physiopathology Hepatology HIV Human immunodeficiency virus Humans Immunohistochemistry Killer Cells, Natural - immunology Killer Cells, Natural - physiology Linear Models Liver Cirrhosis - genetics Liver Cirrhosis - immunology Liver Cirrhosis - physiopathology Liver Cirrhosis - virology Liver Function Tests Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Natural Cytotoxicity Triggering Receptor 1 - genetics Natural Cytotoxicity Triggering Receptor 1 - metabolism Natural Cytotoxicity Triggering Receptor 3 - genetics Natural Cytotoxicity Triggering Receptor 3 - immunology Other diseases. Semiology RNA, Viral - genetics Sensitivity and Specificity Statistics, Nonparametric T cell receptors Virus Replication - genetics Virus Replication - immunology Young Adult
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