Three-Dimensional Geometry of Honeycomb Collagen Promotes Higher Beating Rate of Myocardial Cells in Culture
Myocardial cells were isolated from newborn rats, cultured on a novel three‐dimensional (3‐D) honeycomb collagen scaffold (HC) and their morphology and beating rates compared with ones on conventional plastic dishes. On the first day, the cells attached to HC had already started beating. As time wen...
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| Veröffentlicht in: | Artificial organs 2012-09, Vol.36 (9), p.816-819 |
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| container_title | Artificial organs |
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| creator | Guo, Zhikun Iku, Shouhei Zheng, Xianjie Sammons, Rachel L. Kuboki, Yoshinori |
| description | Myocardial cells were isolated from newborn rats, cultured on a novel three‐dimensional (3‐D) honeycomb collagen scaffold (HC) and their morphology and beating rates compared with ones on conventional plastic dishes. On the first day, the cells attached to HC had already started beating. As time went on, the rate of beating increased as the pores of HC gradually filled with the cells, which integrated to form the cell–matrix complex. At day 8, beating reached the highest frequency of 162 beats per minute, which was twice that of the control cells on plastic dishes. It was concluded that 3‐D geometry of the HC is conducive to functional growth of the myocardial tissues, and will potentially be useful for tissue engineering of myocardial regeneration. |
| doi_str_mv | 10.1111/j.1525-1594.2012.01446.x |
| format | Article |
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Artificial Organs © 2012, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc</rights><rights>2012, Copyright the Authors. 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It was concluded that 3‐D geometry of the HC is conducive to functional growth of the myocardial tissues, and will potentially be useful for tissue engineering of myocardial regeneration.</description><subject>Animals</subject><subject>Beating rate</subject><subject>Biocompatibility</subject><subject>Cell culture</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Collagen - chemistry</subject><subject>Honeycomb collagen</subject><subject>Myocardial cells</subject><subject>Myocytes, Cardiac - cytology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Three-dimensional culture</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds - chemistry</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxSMEokvhKyAfuST4f9YHDm1KdxGFLlUR3CwnGW-9JHGxE3Xz7ZuwZc-di0fy-z2P5yUJIjgjU33cZURQkRKheEYxoRkmnMts_yJZHC9eJgtMJE6F5L9Pkjcx7jDGOcfydXJCKVe5YHKRNLd3ASC9cC100fnONGgFvoU-jMhbtPYdjJVvS1T4pjFb6NAm-Nb3ENHabe8goHMwveu26Mb0MCPfRl-ZULvJqYCmich1qBiafgjwNnllTRPh3dN5mvy8_HxbrNOr69WX4uwqrfg0Xzr9UFa8wpbaZc1ZaaiszZJxJSjBuSXcsBrAMmIVt6S0TBhB89zYUi2VVJSdJh8OvvfB_x0g9rp1sZqGMR34IWqCFeO5FIQ8Q8oUxZyz2XV5kFbBxxjA6vvgWhPGSaTnWPROz9vX8_b1HIv-F4veT-j7p1eGsoX6CP7PYRJ8OggeXAPjs4312fXN3E18euBd7GF_5E34o2XOcqF_fV9pvLk8__FVbfSKPQKHIaoK</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Guo, Zhikun</creator><creator>Iku, Shouhei</creator><creator>Zheng, Xianjie</creator><creator>Sammons, Rachel L.</creator><creator>Kuboki, Yoshinori</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201209</creationdate><title>Three-Dimensional Geometry of Honeycomb Collagen Promotes Higher Beating Rate of Myocardial Cells in Culture</title><author>Guo, Zhikun ; Iku, Shouhei ; Zheng, Xianjie ; Sammons, Rachel L. ; Kuboki, Yoshinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4406-1116c4c0f2f8d43ba26da834952107f14a3deef31f94f1bf35a5277afb9896923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Beating rate</topic><topic>Biocompatibility</topic><topic>Cell culture</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Collagen - chemistry</topic><topic>Honeycomb collagen</topic><topic>Myocardial cells</topic><topic>Myocytes, Cardiac - cytology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Three-dimensional culture</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Zhikun</creatorcontrib><creatorcontrib>Iku, Shouhei</creatorcontrib><creatorcontrib>Zheng, Xianjie</creatorcontrib><creatorcontrib>Sammons, Rachel L.</creatorcontrib><creatorcontrib>Kuboki, Yoshinori</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Zhikun</au><au>Iku, Shouhei</au><au>Zheng, Xianjie</au><au>Sammons, Rachel L.</au><au>Kuboki, Yoshinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-Dimensional Geometry of Honeycomb Collagen Promotes Higher Beating Rate of Myocardial Cells in Culture</atitle><jtitle>Artificial organs</jtitle><addtitle>Artif Organs</addtitle><date>2012-09</date><risdate>2012</risdate><volume>36</volume><issue>9</issue><spage>816</spage><epage>819</epage><pages>816-819</pages><issn>0160-564X</issn><eissn>1525-1594</eissn><abstract>Myocardial cells were isolated from newborn rats, cultured on a novel three‐dimensional (3‐D) honeycomb collagen scaffold (HC) and their morphology and beating rates compared with ones on conventional plastic dishes. 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| ispartof | Artificial organs, 2012-09, Vol.36 (9), p.816-819 |
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| subjects | Animals Beating rate Biocompatibility Cell culture Cell Proliferation Cells, Cultured Collagen - chemistry Honeycomb collagen Myocardial cells Myocytes, Cardiac - cytology Rats Rats, Sprague-Dawley Three-dimensional culture Tissue Engineering - methods Tissue Scaffolds - chemistry |
| title | Three-Dimensional Geometry of Honeycomb Collagen Promotes Higher Beating Rate of Myocardial Cells in Culture |
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