Acute kidney injury
Summary Acute kidney injury (formerly known as acute renal failure) is a syndrome characterised by the rapid loss of the kidney's excretory function and is typically diagnosed by the accumulation of end products of nitrogen metabolism (urea and creatinine) or decreased urine output, or both. It...
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| Veröffentlicht in: | The Lancet (British edition) 2012-08, Vol.380 (9843), p.756-766 |
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| creator | Bellomo, Rinaldo, Prof Kellum, John A, MD Ronco, Claudio, MD |
| description | Summary Acute kidney injury (formerly known as acute renal failure) is a syndrome characterised by the rapid loss of the kidney's excretory function and is typically diagnosed by the accumulation of end products of nitrogen metabolism (urea and creatinine) or decreased urine output, or both. It is the clinical manifestation of several disorders that affect the kidney acutely. Acute kidney injury is common in hospital patients and very common in critically ill patients. In these patients, it is most often secondary to extrarenal events. How such events cause acute kidney injury is controversial. No specific therapies have emerged that can attenuate acute kidney injury or expedite recovery; thus, treatment is supportive. New diagnostic techniques (eg, renal biomarkers) might help with early diagnosis. Patients are given renal replacement therapy if acute kidney injury is severe and biochemical or volume-related, or if uraemic-toxaemia-related complications are of concern. If patients survive their illness and do not have premorbid chronic kidney disease, they typically recover to dialysis independence. However, evidence suggests that patients who have had acute kidney injury are at increased risk of subsequent chronic kidney disease. |
| doi_str_mv | 10.1016/S0140-6736(11)61454-2 |
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It is the clinical manifestation of several disorders that affect the kidney acutely. Acute kidney injury is common in hospital patients and very common in critically ill patients. In these patients, it is most often secondary to extrarenal events. How such events cause acute kidney injury is controversial. No specific therapies have emerged that can attenuate acute kidney injury or expedite recovery; thus, treatment is supportive. New diagnostic techniques (eg, renal biomarkers) might help with early diagnosis. Patients are given renal replacement therapy if acute kidney injury is severe and biochemical or volume-related, or if uraemic-toxaemia-related complications are of concern. If patients survive their illness and do not have premorbid chronic kidney disease, they typically recover to dialysis independence. However, evidence suggests that patients who have had acute kidney injury are at increased risk of subsequent chronic kidney disease.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(11)61454-2</identifier><identifier>PMID: 22617274</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Acute Kidney Injury - diagnosis ; Acute Kidney Injury - etiology ; Acute Kidney Injury - therapy ; Biochemistry ; Bioindicators ; Biological and medical sciences ; Biomarkers - blood ; Clinical Laboratory Techniques - methods ; Complications ; Dialysis ; Epidemiology ; General aspects ; Hemodialysis ; Hospitals ; Humans ; Injuries ; Internal Medicine ; Kidney ; Kidney diseases ; Kidneys ; Medical sciences ; Mortality ; Nephrology. Urinary tract diseases ; Neurotransmitter Agents - physiology ; Nitrogen ; Prognosis ; Renal Replacement Therapy - methods ; Urea ; Urinary system involvement in other diseases. Miscellaneous ; Urine</subject><ispartof>The Lancet (British edition), 2012-08, Vol.380 (9843), p.756-766</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c633t-760b17e699b7d9969dc213060b313c0ffe2989fbccf3aab56c90332f6ab634393</citedby><cites>FETCH-LOGICAL-c633t-760b17e699b7d9969dc213060b313c0ffe2989fbccf3aab56c90332f6ab634393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1082450862?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3538,27906,27907,45977,64365,64367,64369,72219</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26275488$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22617274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bellomo, Rinaldo, Prof</creatorcontrib><creatorcontrib>Kellum, John A, MD</creatorcontrib><creatorcontrib>Ronco, Claudio, MD</creatorcontrib><title>Acute kidney injury</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Summary Acute kidney injury (formerly known as acute renal failure) is a syndrome characterised by the rapid loss of the kidney's excretory function and is typically diagnosed by the accumulation of end products of nitrogen metabolism (urea and creatinine) or decreased urine output, or both. It is the clinical manifestation of several disorders that affect the kidney acutely. Acute kidney injury is common in hospital patients and very common in critically ill patients. In these patients, it is most often secondary to extrarenal events. How such events cause acute kidney injury is controversial. No specific therapies have emerged that can attenuate acute kidney injury or expedite recovery; thus, treatment is supportive. New diagnostic techniques (eg, renal biomarkers) might help with early diagnosis. Patients are given renal replacement therapy if acute kidney injury is severe and biochemical or volume-related, or if uraemic-toxaemia-related complications are of concern. If patients survive their illness and do not have premorbid chronic kidney disease, they typically recover to dialysis independence. However, evidence suggests that patients who have had acute kidney injury are at increased risk of subsequent chronic kidney disease.</description><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - therapy</subject><subject>Biochemistry</subject><subject>Bioindicators</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Clinical Laboratory Techniques - methods</subject><subject>Complications</subject><subject>Dialysis</subject><subject>Epidemiology</subject><subject>General aspects</subject><subject>Hemodialysis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Injuries</subject><subject>Internal Medicine</subject><subject>Kidney</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Neurotransmitter Agents - physiology</subject><subject>Nitrogen</subject><subject>Prognosis</subject><subject>Renal Replacement Therapy - methods</subject><subject>Urea</subject><subject>Urinary system involvement in other diseases. 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Urinary tract diseases</topic><topic>Neurotransmitter Agents - physiology</topic><topic>Nitrogen</topic><topic>Prognosis</topic><topic>Renal Replacement Therapy - methods</topic><topic>Urea</topic><topic>Urinary system involvement in other diseases. 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It is the clinical manifestation of several disorders that affect the kidney acutely. Acute kidney injury is common in hospital patients and very common in critically ill patients. In these patients, it is most often secondary to extrarenal events. How such events cause acute kidney injury is controversial. No specific therapies have emerged that can attenuate acute kidney injury or expedite recovery; thus, treatment is supportive. New diagnostic techniques (eg, renal biomarkers) might help with early diagnosis. Patients are given renal replacement therapy if acute kidney injury is severe and biochemical or volume-related, or if uraemic-toxaemia-related complications are of concern. If patients survive their illness and do not have premorbid chronic kidney disease, they typically recover to dialysis independence. However, evidence suggests that patients who have had acute kidney injury are at increased risk of subsequent chronic kidney disease.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>22617274</pmid><doi>10.1016/S0140-6736(11)61454-2</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 2012-08, Vol.380 (9843), p.756-766 |
| issn | 0140-6736 1474-547X |
| language | eng |
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| subjects | Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Acute Kidney Injury - therapy Biochemistry Bioindicators Biological and medical sciences Biomarkers - blood Clinical Laboratory Techniques - methods Complications Dialysis Epidemiology General aspects Hemodialysis Hospitals Humans Injuries Internal Medicine Kidney Kidney diseases Kidneys Medical sciences Mortality Nephrology. Urinary tract diseases Neurotransmitter Agents - physiology Nitrogen Prognosis Renal Replacement Therapy - methods Urea Urinary system involvement in other diseases. Miscellaneous Urine |
| title | Acute kidney injury |
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