Chemotactic and Immunoregulatory Properties of Bone Cells are Modulated by Endotoxin-Stimulated Lymphocytes

In our study, we explored the bidirectional communication via soluble factors between bone cells and endotoxin-stimulated splenic lymphocytes in an in vitro coculture model that mimics the inflammatory environment. Both the ability of lymphocytes to affect differentiation and immune properties of bo...

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Veröffentlicht in:	Inflammation 2012-10, Vol.35 (5), p.1618-1631
Hauptverfasser:	Cvija, Hrvoje, Kovacic, Natasa, Katavic, Vedran, Ivcevic, Sanja, Aguila, Hector Leonardo, Marusic, Ana, Grcevic, Danka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Cell Differentiation Cells, Cultured Chemokine CCL2 - biosynthesis Chemokine CCL5 - biosynthesis Chemokine CXCL10 Chemokine CXCL13 - biosynthesis Female Immunology Inflammation Interleukin-1 - biosynthesis Interleukin-6 - biosynthesis Internal Medicine Lipopolysaccharides - immunology Lymphocyte Activation Lymphocytes - immunology Lymphocytes - metabolism Mice Mice, Inbred C57BL Osteoblasts - immunology Osteoblasts - metabolism Osteoclasts - immunology Osteoclasts - metabolism Osteoprotegerin - biosynthesis Pathology Pharmacology/Toxicology RANK Ligand - biosynthesis RANK Ligand - metabolism Rheumatology Tumor Necrosis Factor-alpha - biosynthesis Up-Regulation
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