Calcium-sensing receptor, calcimimetics, and cardiovascular calcifications in chronic kidney disease

Renal function impairment goes along with a disturbed calcium, phosphate, and vitamin D metabolism, resulting in secondary hyperparathyroidism (sHPT). These mineral metabolism disturbances are associated with soft tissue calcifications, particularly arteries, cardiac valves, and myocardium, ultimate...

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Veröffentlicht in:	Kidney international 2012-07, Vol.82 (1), p.19-25
Hauptverfasser:	Ureña Torres, Pablo A., De Broe, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries Arteriosclerosis Biological and medical sciences Calcification Calcification (ectopic) Calcimimetic Agents - therapeutic use calcimimetics Calcinosis - etiology Calcinosis - metabolism Calcinosis - physiopathology Calcium (extracellular) Calcium - metabolism Calcium phosphate calcium receptor Calcium-sensing receptors Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology Chronic Disease Dialysis Endocrinopathies Humans hyperparathyroidism Hyperparathyroidism, Secondary - etiology Hyperparathyroidism, Secondary - metabolism Hyperparathyroidism, Secondary - physiopathology Hyperparathyroidism, Secondary - therapy Kidney - drug effects Kidney - metabolism Kidney - physiopathology Kidney diseases Kidney Diseases - complications Kidney Diseases - metabolism Kidney Diseases - physiopathology Kidney Diseases - therapy Kidneys Medical sciences Metabolism Mineralization Mortality Myocardium Nephrology. Urinary tract diseases Non tumoral diseases. Target tissue resistance. Benign neoplasms Parathyroid hormone Parathyroid Hormone - metabolism Parathyroid hormone-related protein Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) Phosphate Phosphates - metabolism Receptors, Calcium-Sensing - agonists Receptors, Calcium-Sensing - metabolism Renal function renal osteodystrophy Risk Factors Structure-function relationships Urinary system involvement in other diseases. Miscellaneous vascular calcification Vascular Calcification - etiology Vascular Calcification - metabolism Vascular Calcification - physiopathology Vitamin D
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