Silibinin Is a Potent Sensitizer of UVA Radiation-induced Oxidative Stress and Apoptosis in Human Keratinocyte HaCaT Cells

UVA radiation (315–400 nm), which constitutes ca 95% of the UV irradiation in natural sunlight reaching earth surface, is a major environmental risk factor associated with human skin cancer pathogenesis. UVA is an oxidizing agent that causes significant damage to cellular components through the rele...

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Veröffentlicht in:	Photochemistry and photobiology 2012-09, Vol.88 (5), p.1135-1140
Hauptverfasser:	Narayanapillai, Sreekanth, Agarwal, Chapla, Tilley, Cynthia, Agarwal, Rajesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Cell Line Cell Survival - drug effects Cell Survival - radiation effects Cells Chemical compounds Dose-Response Relationship, Radiation Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - radiation effects Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - radiation effects Gene Expression - drug effects Gene Expression - radiation effects Humans Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - radiation effects Oxidative stress Oxidative Stress - drug effects Oxidative Stress - radiation effects Photobiology Photosensitizing Agents - pharmacology Reactive Oxygen Species - agonists Reactive Oxygen Species - metabolism Silybin Silybum marianum Silybum marianum - chemistry Silymarin - pharmacology Skin cancer Transcription Factor CHOP - agonists Transcription Factor CHOP - genetics Ultraviolet radiation Ultraviolet Rays - adverse effects
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