Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies
Evidence for an association between fruit and vegetable intake and breast cancer risk is inconclusive. To clarify the association, we conducted a systematic review and meta-analysis of the evidence from prospective studies. We searched PubMed for prospective studies of fruit and vegetable intake and...
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| Veröffentlicht in: | Breast cancer research and treatment 2012-07, Vol.134 (2), p.479-493 |
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| container_title | Breast cancer research and treatment |
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| creator | Aune, D. Chan, D. S. M. Vieira, A. R. Rosenblatt, D. A. Navarro Vieira, R. Greenwood, D. C. Norat, T. |
| description | Evidence for an association between fruit and vegetable intake and breast cancer risk is inconclusive. To clarify the association, we conducted a systematic review and meta-analysis of the evidence from prospective studies. We searched PubMed for prospective studies of fruit and vegetable intake and breast cancer risk until April 30, 2011. We included fifteen prospective studies that reported relative risk estimates and 95 % confidence intervals (CIs) of breast cancer associated with fruit and vegetable intake. Random effects models were used to estimate summary relative risks. The summary relative risk (RR) for the highest versus the lowest intake was 0.89 (95 % CI: 0.80–0.99,
I
2
= 0 %) for fruits and vegetables combined, 0.92 (95 % CI: 0.86–0.98,
I
2
= 9 %) for fruits, and 0.99 (95 % CI: 0.92–1.06,
I
2
= 20 %) for vegetables. In dose–response analyses, the summary RR per 200 g/day was 0.96 (95 % CI: 0.93–1.00,
I
2
= 2 %) for fruits and vegetables combined, 0.94 (95 % CI: 0.89–1.00,
I
2
= 39 %) for fruits, and 1.00 (95 % CI: 0.95–1.06,
I
2
= 17 %) for vegetables. In this meta-analysis of prospective studies, high intake of fruits, and fruits and vegetables combined, but not vegetables, is associated with a weak reduction in risk of breast cancer. |
| doi_str_mv | 10.1007/s10549-012-2118-1 |
| format | Article |
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I
2
= 0 %) for fruits and vegetables combined, 0.92 (95 % CI: 0.86–0.98,
I
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= 9 %) for fruits, and 0.99 (95 % CI: 0.92–1.06,
I
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= 20 %) for vegetables. In dose–response analyses, the summary RR per 200 g/day was 0.96 (95 % CI: 0.93–1.00,
I
2
= 2 %) for fruits and vegetables combined, 0.94 (95 % CI: 0.89–1.00,
I
2
= 39 %) for fruits, and 1.00 (95 % CI: 0.95–1.06,
I
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I
2
= 0 %) for fruits and vegetables combined, 0.92 (95 % CI: 0.86–0.98,
I
2
= 9 %) for fruits, and 0.99 (95 % CI: 0.92–1.06,
I
2
= 20 %) for vegetables. In dose–response analyses, the summary RR per 200 g/day was 0.96 (95 % CI: 0.93–1.00,
I
2
= 2 %) for fruits and vegetables combined, 0.94 (95 % CI: 0.89–1.00,
I
2
= 39 %) for fruits, and 1.00 (95 % CI: 0.95–1.06,
I
2
= 17 %) for vegetables. In this meta-analysis of prospective studies, high intake of fruits, and fruits and vegetables combined, but not vegetables, is associated with a weak reduction in risk of breast cancer.</description><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Diet</subject><subject>Dose-response effects</subject><subject>Female</subject><subject>Fruit</subject><subject>Fruit - adverse effects</subject><subject>Fruits</subject><subject>Gynecology. Andrology. 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S. M.</au><au>Vieira, A. R.</au><au>Rosenblatt, D. A. Navarro</au><au>Vieira, R.</au><au>Greenwood, D. C.</au><au>Norat, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><addtitle>Breast Cancer Res Treat</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>134</volume><issue>2</issue><spage>479</spage><epage>493</epage><pages>479-493</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>Evidence for an association between fruit and vegetable intake and breast cancer risk is inconclusive. To clarify the association, we conducted a systematic review and meta-analysis of the evidence from prospective studies. We searched PubMed for prospective studies of fruit and vegetable intake and breast cancer risk until April 30, 2011. We included fifteen prospective studies that reported relative risk estimates and 95 % confidence intervals (CIs) of breast cancer associated with fruit and vegetable intake. Random effects models were used to estimate summary relative risks. The summary relative risk (RR) for the highest versus the lowest intake was 0.89 (95 % CI: 0.80–0.99,
I
2
= 0 %) for fruits and vegetables combined, 0.92 (95 % CI: 0.86–0.98,
I
2
= 9 %) for fruits, and 0.99 (95 % CI: 0.92–1.06,
I
2
= 20 %) for vegetables. In dose–response analyses, the summary RR per 200 g/day was 0.96 (95 % CI: 0.93–1.00,
I
2
= 2 %) for fruits and vegetables combined, 0.94 (95 % CI: 0.89–1.00,
I
2
= 39 %) for fruits, and 1.00 (95 % CI: 0.95–1.06,
I
2
= 17 %) for vegetables. In this meta-analysis of prospective studies, high intake of fruits, and fruits and vegetables combined, but not vegetables, is associated with a weak reduction in risk of breast cancer.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22706630</pmid><doi>10.1007/s10549-012-2118-1</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biological and medical sciences Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - etiology Cancer Cancer research Diet Dose-response effects Female Fruit Fruit - adverse effects Fruits Gynecology. Andrology. Obstetrics Health aspects Humans Mammary gland diseases Medical sciences Medicine Medicine & Public Health Oncology Oncology, Experimental Prospective Studies Review Reviews Risk Factors Systematic review Tumors Vegetables Vegetables - adverse effects |
| title | Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies |
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