Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and associated changes in the Ca²⁺-induced mitochondrial permeability transition and mitochondrial membrane potential in AML12 hepatocytes

The effects of the schisandrin B stereoisomers, (±)γ-schisandrin [(±)γ-Sch] and (-)schisandrin B [(-)Sch B], on hypoxia/reoxygenation-induced apoptosis were investigated in AML12 hepatocytes. Changes in cellular reduced glutathione (GSH) levels, Ca²⁺-induced mitochondrial permeability transitions (M...

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Veröffentlicht in:	Phytotherapy research 2009-11, Vol.23 (11), p.1592-1602
Hauptverfasser:	Chiu, Po Yee, Luk, Ka Fai, Leung, Hoi Yan, Ng, Ka Ming, Ko, Kam Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	AML12 Apoptosis Biological and medical sciences Caspase-3 Cytochrome c Drugs General pharmacology Glutathione Hepatocytes Hypoxia hypoxia/reoxygenation Medical sciences Membrane permeability Membrane potential Mitochondria mitochondrial membrane potential mitochondrial permeability transition Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Pores schisandrin B Stereoisomers
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