Age-related memory decline is associated with vascular and microglial degeneration in aged rats

► Memory impairment with age associated with microglial and vascular degeneration. ► Reduced VEGF expression with age impaired vascular remodeling and memory. ► Glial and vessel degeneration may represent pathology of MCI, but not dementia. The hippocampus processes memory is an early target of agin...

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Veröffentlicht in:	Behavioural brain research 2012-12, Vol.235 (2), p.210-217
Hauptverfasser:	Zhang, Rong, Kadar, Tamar, Sirimanne, Ernest, MacGibbon, Alastair, Guan, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Aging Analysis of Variance Animals Antigens, Surface - metabolism Brain Brain - metabolism Brain - pathology Capillaries Choline O-Acetyltransferase - metabolism Data processing Disease Models, Animal Dopamine Glial cells Glial degeneration Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Hippocampus Immunochemistry Locomotion - physiology Male Maze Learning Memory Memory Disorders - complications Memory Disorders - pathology Microglia - metabolism Microglia - pathology Microvasculature Nerve Tissue Proteins - metabolism Neurodegeneration Neuronal-glial interactions Nitric Oxide Synthase Type I - metabolism Normal aging Probes Rats Swimming Tyrosine 3-Monooxygenase - metabolism Vascular degeneration and VEGF expression Vascular Diseases - complications Vascular Diseases - pathology Vascular endothelial growth factor Vascular Endothelial Growth Factors
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