New approach to analyze genetic and clinical data in bisphosphonate-induced osteonecrosis of the jaw

Oral Diseases (2012) 18, 580–585 Objectives: Osteonecrosis of the jaw (ONJ) is a major complication associated with long‐term use of bisphosphonates (BP). We aimed to investigate the effect of CYP2C8 rs1934951 SNP and its relationship to a number of clinical and biochemical factors in 46 Hungarian...

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Veröffentlicht in:	Oral diseases 2012-09, Vol.18 (6), p.580-585
Hauptverfasser:	Balla, B, Vaszilko, M, Kósa, JP, Podani, J, Takács, I, Tóbiás, B, Nagy, Z, Lazáry, Á, Lakatos, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Administration, Intravenous Administration, Oral Aged Aged, 80 and over Antineoplastic Agents, Hormonal - therapeutic use Aryl Hydrocarbon Hydroxylases - genetics Bisphosphonate-Associated Osteonecrosis of the Jaw - enzymology Bisphosphonate-Associated Osteonecrosis of the Jaw - genetics Bisphosphonates Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - adverse effects Breast cancer Breast Neoplasms - drug therapy Calcium - blood CYP2C8 polymorphism Cytochrome P-450 CYP2C8 Data processing Dentistry Diphosphonates - administration & dosage Diphosphonates - adverse effects DNA probes Estrogen Receptor Modulators - therapeutic use Female genomics Genotype Genotypes Guanine Humans Hungary Intravenous administration Jaw Lipids - blood Male Mandible Mandibular Diseases - enzymology Mandibular Diseases - genetics maxilla Maxillary Diseases - genetics Medical research Middle Aged Osteonecrosis osteonecrosis of the jaws Parathyroid hormone Parathyroid Hormone - blood Polymorphism, Single Nucleotide - genetics Primers Principal Component Analysis Principal components analysis Recurrence Serum lipids Single-nucleotide polymorphism Statistics Time Factors Vitamin D - analogs & derivatives Vitamin D - blood
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