Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and nonparallel physiological divergence
Across multiple lakes in North America, lake whitefish ( Coregonus clupeaformis) have independently evolved ‘dwarf’ and ‘normal’ sympatric species pairs that exhibit pronounced phenotypic and genetic divergence. In particular, traits associated with metabolism have been shown to be highly differenti...
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| Veröffentlicht in: | Journal of evolutionary biology 2012-09, Vol.25 (9), p.1823-1834 |
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| creator | Evans, M. L. Bernatchez, L. |
| description | Across multiple lakes in North America, lake whitefish (
Coregonus clupeaformis) have independently evolved ‘dwarf’ and ‘normal’ sympatric species pairs that exhibit pronounced phenotypic and genetic divergence. In particular, traits associated with metabolism have been shown to be highly differentiated between whitefish species. Here, we examine the transcription of genes associated with the five mitochondrial and nuclear genome‐encoded oxidative phosphorylation (OXPHOS) complexes, the primary physiological mechanism responsible for the production of ATP, in whitefish species pairs from Cliff Lake and Webster Lake in Maine, USA. We observed OXPHOS gene transcription divergence between dwarf and normal whitefish in each of the two lakes, with the former exhibiting transcription upregulation for genes associated with each of the OXPHOS complexes. We also observed a significant influence of lake on transcription levels for some of the genes, indicating that inter‐lake ecological or genetic differences are contributing to variation in OXPHOS gene transcription levels. Together, our results support the hypothesis that metabolic divergence is a critical adaptation involved in whitefish speciation and implicate OXPHOS gene upregulation as a factor involved in meeting the enhanced energetic demands of dwarf whitefish. Further studies are now needed to evaluate the contribution of genetically vs. plasticity driven variation in transcription associated with this critical physiological pathway. |
| doi_str_mv | 10.1111/j.1420-9101.2012.02570.x |
| format | Article |
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Coregonus clupeaformis) have independently evolved ‘dwarf’ and ‘normal’ sympatric species pairs that exhibit pronounced phenotypic and genetic divergence. In particular, traits associated with metabolism have been shown to be highly differentiated between whitefish species. Here, we examine the transcription of genes associated with the five mitochondrial and nuclear genome‐encoded oxidative phosphorylation (OXPHOS) complexes, the primary physiological mechanism responsible for the production of ATP, in whitefish species pairs from Cliff Lake and Webster Lake in Maine, USA. We observed OXPHOS gene transcription divergence between dwarf and normal whitefish in each of the two lakes, with the former exhibiting transcription upregulation for genes associated with each of the OXPHOS complexes. We also observed a significant influence of lake on transcription levels for some of the genes, indicating that inter‐lake ecological or genetic differences are contributing to variation in OXPHOS gene transcription levels. Together, our results support the hypothesis that metabolic divergence is a critical adaptation involved in whitefish speciation and implicate OXPHOS gene upregulation as a factor involved in meeting the enhanced energetic demands of dwarf whitefish. Further studies are now needed to evaluate the contribution of genetically vs. plasticity driven variation in transcription associated with this critical physiological pathway.</description><identifier>ISSN: 1010-061X</identifier><identifier>EISSN: 1420-9101</identifier><identifier>DOI: 10.1111/j.1420-9101.2012.02570.x</identifier><identifier>PMID: 22830417</identifier><language>eng</language><publisher>Switzerland: Blackwell Publishing Ltd</publisher><subject>Adaptation, Biological ; Adenosine Triphosphate - genetics ; Adenosine Triphosphate - metabolism ; Animals ; Base Sequence ; Cell Nucleus - genetics ; Coregonus ; Coregonus clupeaformis ; DNA, Mitochondrial - genetics ; Ecosystem ; Evolutionary biology ; Fish ; Gene Expression Profiling - methods ; Gene Expression Regulation ; gene transcription ; Genes, Mitochondrial ; Genetic Speciation ; Genetics, Population - methods ; Lakes ; Maine ; metabolism ; Mitochondria - genetics ; Oxidative Phosphorylation ; Oxidative stress ; phenotypic divergence ; Phosphorylation ; physiology ; Salmonidae - genetics ; Salmonidae - metabolism ; Salmonidae - physiology ; speciation ; Species Specificity ; Statistics, Nonparametric ; Sympatry ; Transcription, Genetic ; Up-Regulation</subject><ispartof>Journal of evolutionary biology, 2012-09, Vol.25 (9), p.1823-1834</ispartof><rights>2012 The Authors. Journal of Evolutionary Biology © 2012 European Society For Evolutionary Biology</rights><rights>2012 The Authors. Journal of Evolutionary Biology © 2012 European Society For Evolutionary Biology.</rights><rights>Journal of Evolutionary Biology © 2012 European Society For Evolutionary Biology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4800-8391a1fee96735542eebd72928b016a807dead4505c8be031888a4841ab8fb1b3</citedby><cites>FETCH-LOGICAL-c4800-8391a1fee96735542eebd72928b016a807dead4505c8be031888a4841ab8fb1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1420-9101.2012.02570.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1420-9101.2012.02570.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22830417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evans, M. L.</creatorcontrib><creatorcontrib>Bernatchez, L.</creatorcontrib><title>Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and nonparallel physiological divergence</title><title>Journal of evolutionary biology</title><addtitle>J Evol Biol</addtitle><description>Across multiple lakes in North America, lake whitefish (
Coregonus clupeaformis) have independently evolved ‘dwarf’ and ‘normal’ sympatric species pairs that exhibit pronounced phenotypic and genetic divergence. In particular, traits associated with metabolism have been shown to be highly differentiated between whitefish species. Here, we examine the transcription of genes associated with the five mitochondrial and nuclear genome‐encoded oxidative phosphorylation (OXPHOS) complexes, the primary physiological mechanism responsible for the production of ATP, in whitefish species pairs from Cliff Lake and Webster Lake in Maine, USA. We observed OXPHOS gene transcription divergence between dwarf and normal whitefish in each of the two lakes, with the former exhibiting transcription upregulation for genes associated with each of the OXPHOS complexes. We also observed a significant influence of lake on transcription levels for some of the genes, indicating that inter‐lake ecological or genetic differences are contributing to variation in OXPHOS gene transcription levels. Together, our results support the hypothesis that metabolic divergence is a critical adaptation involved in whitefish speciation and implicate OXPHOS gene upregulation as a factor involved in meeting the enhanced energetic demands of dwarf whitefish. Further studies are now needed to evaluate the contribution of genetically vs. plasticity driven variation in transcription associated with this critical physiological pathway.</description><subject>Adaptation, Biological</subject><subject>Adenosine Triphosphate - genetics</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Cell Nucleus - genetics</subject><subject>Coregonus</subject><subject>Coregonus clupeaformis</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Ecosystem</subject><subject>Evolutionary biology</subject><subject>Fish</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation</subject><subject>gene transcription</subject><subject>Genes, Mitochondrial</subject><subject>Genetic Speciation</subject><subject>Genetics, Population - methods</subject><subject>Lakes</subject><subject>Maine</subject><subject>metabolism</subject><subject>Mitochondria - genetics</subject><subject>Oxidative Phosphorylation</subject><subject>Oxidative stress</subject><subject>phenotypic divergence</subject><subject>Phosphorylation</subject><subject>physiology</subject><subject>Salmonidae - genetics</subject><subject>Salmonidae - metabolism</subject><subject>Salmonidae - physiology</subject><subject>speciation</subject><subject>Species Specificity</subject><subject>Statistics, Nonparametric</subject><subject>Sympatry</subject><subject>Transcription, Genetic</subject><subject>Up-Regulation</subject><issn>1010-061X</issn><issn>1420-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EoqXwF5AlLlwSxh9JnAMHqFo-VKkXkLhZTjLpeuW1g51td38E_xlnt-yBUy2N_I79zIxGLyGUQcny-bAumeRQtAxYyYHxEnjVQLl7Rs5PH8-zBgYF1OzXGXmV0hqA1bKqXpIzzpUAyZpz8ud2Zwcz23uk0yqkHHHvch48vUOPdI7Gpz7a6fBkPX1Y2RlHm1Y0TdhbTHQyNiYa8R6NW7J5xugTDWPW0TiHjho_UB_8KZ9W-2SDC3e2N44OeXrM03p8TV6MuQm-ebwvyM_rqx-XX4ub2y_fLj_dFL1UAIUSLTNsRGzrRlSV5Ijd0PCWqy6vaBQ0A5pBVlD1qkMQTCllpJLMdGrsWCcuyPtj3ymG31tMs97Y1KNzxmPYJs2gFbJqmhqegApRK15LltF3_6HrsI0-L3KgeNPWIDOljlQfQ0oRRz1FuzFxnyG9uKvXejFRLybqxV19cFfvcunbxwHbboPDqfCfnRn4eAQerMP9kxvr71efFyX-ApOTtXs</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Evans, M. L.</creator><creator>Bernatchez, L.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>201209</creationdate><title>Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and nonparallel physiological divergence</title><author>Evans, M. L. ; Bernatchez, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4800-8391a1fee96735542eebd72928b016a807dead4505c8be031888a4841ab8fb1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adaptation, Biological</topic><topic>Adenosine Triphosphate - genetics</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Cell Nucleus - genetics</topic><topic>Coregonus</topic><topic>Coregonus clupeaformis</topic><topic>DNA, Mitochondrial - genetics</topic><topic>Ecosystem</topic><topic>Evolutionary biology</topic><topic>Fish</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation</topic><topic>gene transcription</topic><topic>Genes, Mitochondrial</topic><topic>Genetic Speciation</topic><topic>Genetics, Population - methods</topic><topic>Lakes</topic><topic>Maine</topic><topic>metabolism</topic><topic>Mitochondria - genetics</topic><topic>Oxidative Phosphorylation</topic><topic>Oxidative stress</topic><topic>phenotypic divergence</topic><topic>Phosphorylation</topic><topic>physiology</topic><topic>Salmonidae - genetics</topic><topic>Salmonidae - metabolism</topic><topic>Salmonidae - physiology</topic><topic>speciation</topic><topic>Species Specificity</topic><topic>Statistics, Nonparametric</topic><topic>Sympatry</topic><topic>Transcription, Genetic</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evans, M. 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L.</au><au>Bernatchez, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and nonparallel physiological divergence</atitle><jtitle>Journal of evolutionary biology</jtitle><addtitle>J Evol Biol</addtitle><date>2012-09</date><risdate>2012</risdate><volume>25</volume><issue>9</issue><spage>1823</spage><epage>1834</epage><pages>1823-1834</pages><issn>1010-061X</issn><eissn>1420-9101</eissn><abstract>Across multiple lakes in North America, lake whitefish (
Coregonus clupeaformis) have independently evolved ‘dwarf’ and ‘normal’ sympatric species pairs that exhibit pronounced phenotypic and genetic divergence. In particular, traits associated with metabolism have been shown to be highly differentiated between whitefish species. Here, we examine the transcription of genes associated with the five mitochondrial and nuclear genome‐encoded oxidative phosphorylation (OXPHOS) complexes, the primary physiological mechanism responsible for the production of ATP, in whitefish species pairs from Cliff Lake and Webster Lake in Maine, USA. We observed OXPHOS gene transcription divergence between dwarf and normal whitefish in each of the two lakes, with the former exhibiting transcription upregulation for genes associated with each of the OXPHOS complexes. We also observed a significant influence of lake on transcription levels for some of the genes, indicating that inter‐lake ecological or genetic differences are contributing to variation in OXPHOS gene transcription levels. Together, our results support the hypothesis that metabolic divergence is a critical adaptation involved in whitefish speciation and implicate OXPHOS gene upregulation as a factor involved in meeting the enhanced energetic demands of dwarf whitefish. Further studies are now needed to evaluate the contribution of genetically vs. plasticity driven variation in transcription associated with this critical physiological pathway.</abstract><cop>Switzerland</cop><pub>Blackwell Publishing Ltd</pub><pmid>22830417</pmid><doi>10.1111/j.1420-9101.2012.02570.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation, Biological Adenosine Triphosphate - genetics Adenosine Triphosphate - metabolism Animals Base Sequence Cell Nucleus - genetics Coregonus Coregonus clupeaformis DNA, Mitochondrial - genetics Ecosystem Evolutionary biology Fish Gene Expression Profiling - methods Gene Expression Regulation gene transcription Genes, Mitochondrial Genetic Speciation Genetics, Population - methods Lakes Maine metabolism Mitochondria - genetics Oxidative Phosphorylation Oxidative stress phenotypic divergence Phosphorylation physiology Salmonidae - genetics Salmonidae - metabolism Salmonidae - physiology speciation Species Specificity Statistics, Nonparametric Sympatry Transcription, Genetic Up-Regulation |
| title | Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and nonparallel physiological divergence |
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