Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

The spindle assembly checkpoint (SAC) is the major surveillance system that ensures that sister chromatids do not separate until all chromosomes are correctly bioriented during mitosis. Components of the checkpoint include Mad1, Mad2, Mad3 (BubR1), Bub3, and the kinases Bub1, Mph1 (Mps1), and Aurora...

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Veröffentlicht in:	Current biology 2012-05, Vol.22 (10), p.891-899
Hauptverfasser:	Shepperd, Lindsey A., Meadows, John C., Sochaj, Alicja M., Lancaster, Theresa C., Zou, Juan, Buttrick, Graham J., Rappsilber, Juri, Hardwick, Kevin G., Millar, Jonathan B.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase-promoting complex aurora B protein BUBR1 protein Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism chromatids Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosomes cohesion Cyclins Dissolution Gene Expression Regulation, Fungal I Kappa B epsilon protein kinases Kinetochores Kinetochores - metabolism M Phase Cell Cycle Checkpoints - physiology Microtubules Mitosis monitoring Phosphorylation Phosphorylation - physiology Protein Kinases - genetics Protein Kinases - metabolism Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism proteins Recruitment Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism securin sister chromatids Spindles
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