Experimental investigation of the immunoregulatory and anti-inflammatory effects of the traditional Chinese medicine “Li-Yan Zhi-Ke Granule” for relieving chronic pharyngitis in rats
Chronic pharyngitis, a chronic inflammation of the pharyngeal mucous membrane and submucous lymphoid tissues, is often caused by unsatisfactory treatment of acute pharyngitis or repeated occurrences of upper respiratory tract infection and is related to a high-dust environment. Traditional herbal ph...
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| Veröffentlicht in: | Molecular biology reports 2011, Vol.38 (1), p.199-203 |
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| creator | Sun, Yiyi Zang, Zhihe Xu, Xiaohong Zhang, Zhonglin Zhong, Ling Zan, Wang Zhao, Yan Sun, Lin |
| description | Chronic pharyngitis, a chronic inflammation of the pharyngeal mucous membrane and submucous lymphoid tissues, is often caused by unsatisfactory treatment of acute pharyngitis or repeated occurrences of upper respiratory tract infection and is related to a high-dust environment. Traditional herbal pharmacotherapy is well known for combining plant species to create complex phytochemical mixtures in the attempt to ameliorate pathophysiological processes. The aim of current study is to investigate the effect of immunoregulation and anti-inflammation with the traditional Chinese medicine (TCM) “Li-Yan Zhi-Ke Granule” in rats. Determination of serum hemolysin and the carbon particle clearance test were performed. The results demonstrate that administration of the TCM “Li-Yan Zhi-Ke Granule” may improve the effect of phagocytosis by mononuclear macrophages and immune function in rats, and may also increase the immunoregulatory and anti-inflammatory responses of rats with chronic pharyngitis. This traditional drug could relieve the symptoms of sore throat and cough in rats with chronic pharyngitis. |
| doi_str_mv | 10.1007/s11033-010-0095-1 |
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Traditional herbal pharmacotherapy is well known for combining plant species to create complex phytochemical mixtures in the attempt to ameliorate pathophysiological processes. The aim of current study is to investigate the effect of immunoregulation and anti-inflammation with the traditional Chinese medicine (TCM) “Li-Yan Zhi-Ke Granule” in rats. Determination of serum hemolysin and the carbon particle clearance test were performed. The results demonstrate that administration of the TCM “Li-Yan Zhi-Ke Granule” may improve the effect of phagocytosis by mononuclear macrophages and immune function in rats, and may also increase the immunoregulatory and anti-inflammatory responses of rats with chronic pharyngitis. This traditional drug could relieve the symptoms of sore throat and cough in rats with chronic pharyngitis.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-010-0095-1</identifier><identifier>PMID: 20349277</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Animals ; Anti-inflammation ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Antibody Formation - drug effects ; Biomedical and Life Sciences ; Carbon ; Chinese medicine ; Chronic Disease ; Chronic infection ; Chronic pharyngitis ; Cough ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; Granules ; Hemolysin Proteins - blood ; Hemolysin Proteins - immunology ; Hemolysins ; Histology ; Immune response ; Immunomodulation - drug effects ; Immunoregulation ; Immunosuppressive agents ; Inflammation ; Inflammatory diseases ; Life Sciences ; Lymphoid tissue ; Macrophages ; Medicine, Chinese Traditional ; Mice ; Mononuclear Phagocyte System - drug effects ; Morphology ; Phagocytosis ; Phagocytosis - drug effects ; Pharyngitis ; Pharyngitis - blood ; Pharyngitis - drug therapy ; Pharynx ; Phytotherapy ; Rats ; Respiratory tract diseases ; Rodents ; Traditional Chinese Medicine</subject><ispartof>Molecular biology reports, 2011, Vol.38 (1), p.199-203</ispartof><rights>Springer Science+Business Media B.V. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-c107862178fe220dc8ea6a055bd4cc29c4e9efa7299be83d236145570f54e4223</citedby><cites>FETCH-LOGICAL-c427t-c107862178fe220dc8ea6a055bd4cc29c4e9efa7299be83d236145570f54e4223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-010-0095-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-010-0095-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20349277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Yiyi</creatorcontrib><creatorcontrib>Zang, Zhihe</creatorcontrib><creatorcontrib>Xu, Xiaohong</creatorcontrib><creatorcontrib>Zhang, Zhonglin</creatorcontrib><creatorcontrib>Zhong, Ling</creatorcontrib><creatorcontrib>Zan, Wang</creatorcontrib><creatorcontrib>Zhao, Yan</creatorcontrib><creatorcontrib>Sun, Lin</creatorcontrib><title>Experimental investigation of the immunoregulatory and anti-inflammatory effects of the traditional Chinese medicine “Li-Yan Zhi-Ke Granule” for relieving chronic pharyngitis in rats</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Chronic pharyngitis, a chronic inflammation of the pharyngeal mucous membrane and submucous lymphoid tissues, is often caused by unsatisfactory treatment of acute pharyngitis or repeated occurrences of upper respiratory tract infection and is related to a high-dust environment. Traditional herbal pharmacotherapy is well known for combining plant species to create complex phytochemical mixtures in the attempt to ameliorate pathophysiological processes. The aim of current study is to investigate the effect of immunoregulation and anti-inflammation with the traditional Chinese medicine (TCM) “Li-Yan Zhi-Ke Granule” in rats. Determination of serum hemolysin and the carbon particle clearance test were performed. The results demonstrate that administration of the TCM “Li-Yan Zhi-Ke Granule” may improve the effect of phagocytosis by mononuclear macrophages and immune function in rats, and may also increase the immunoregulatory and anti-inflammatory responses of rats with chronic pharyngitis. This traditional drug could relieve the symptoms of sore throat and cough in rats with chronic pharyngitis.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animals</subject><subject>Anti-inflammation</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antibody Formation - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Carbon</subject><subject>Chinese medicine</subject><subject>Chronic Disease</subject><subject>Chronic infection</subject><subject>Chronic pharyngitis</subject><subject>Cough</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Granules</subject><subject>Hemolysin Proteins - blood</subject><subject>Hemolysin Proteins - immunology</subject><subject>Hemolysins</subject><subject>Histology</subject><subject>Immune response</subject><subject>Immunomodulation - 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Traditional herbal pharmacotherapy is well known for combining plant species to create complex phytochemical mixtures in the attempt to ameliorate pathophysiological processes. The aim of current study is to investigate the effect of immunoregulation and anti-inflammation with the traditional Chinese medicine (TCM) “Li-Yan Zhi-Ke Granule” in rats. Determination of serum hemolysin and the carbon particle clearance test were performed. The results demonstrate that administration of the TCM “Li-Yan Zhi-Ke Granule” may improve the effect of phagocytosis by mononuclear macrophages and immune function in rats, and may also increase the immunoregulatory and anti-inflammatory responses of rats with chronic pharyngitis. This traditional drug could relieve the symptoms of sore throat and cough in rats with chronic pharyngitis.</abstract><cop>Dordrecht</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>20349277</pmid><doi>10.1007/s11033-010-0095-1</doi><tpages>5</tpages></addata></record> |
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| subjects | Animal Anatomy Animal Biochemistry Animals Anti-inflammation Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antibody Formation - drug effects Biomedical and Life Sciences Carbon Chinese medicine Chronic Disease Chronic infection Chronic pharyngitis Cough Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Granules Hemolysin Proteins - blood Hemolysin Proteins - immunology Hemolysins Histology Immune response Immunomodulation - drug effects Immunoregulation Immunosuppressive agents Inflammation Inflammatory diseases Life Sciences Lymphoid tissue Macrophages Medicine, Chinese Traditional Mice Mononuclear Phagocyte System - drug effects Morphology Phagocytosis Phagocytosis - drug effects Pharyngitis Pharyngitis - blood Pharyngitis - drug therapy Pharynx Phytotherapy Rats Respiratory tract diseases Rodents Traditional Chinese Medicine |
| title | Experimental investigation of the immunoregulatory and anti-inflammatory effects of the traditional Chinese medicine “Li-Yan Zhi-Ke Granule” for relieving chronic pharyngitis in rats |
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