A functional polymorphism in PER3 gene is associated with prognosis in hepatocellular carcinoma
Background Previous studies have revealed that circadian genes play important roles in cell proliferation, apoptosis, cell cycle control, DNA damage response and treatment response of chemotherapy agents in cancers. Aims We hypothesized that the polymorphisms in circadian genes may be associated wit...
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| Veröffentlicht in: | Liver international 2012-10, Vol.32 (9), p.1451-1459 |
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| creator | Zhao, Binyu Lu, Jianguo Yin, Jikai Liu, Hanqiang Guo, Xu Yang, Yefa Ge, Naijian Zhu, Yong Zhang, Hongxin Xing, Jinliang |
| description | Background
Previous studies have revealed that circadian genes play important roles in cell proliferation, apoptosis, cell cycle control, DNA damage response and treatment response of chemotherapy agents in cancers.
Aims
We hypothesized that the polymorphisms in circadian genes may be associated with prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE).
Methods
Twelve functional single nucleotide polymorphisms (SNPs) in circadian negative feedback regulation genes (including
CRY1, CRY2, PER1, PER2 and
PER3) were genotyped using Sequenom iPLEX genotyping method in 337 HCC patients treated with TACE and analysed for associations with overall survival.
Results
Our data showed that one SNP rs2640908 in
PER3 gene was significantly associated with overall survival of HCC patients (P = 0.027). Patients carrying at least one variant allele of rs2640908 (WV + VV) had a significantly decreased risk of death (hazard ratio, 0.71; 95% confidence interval, 0.53–0.90), when compared with those carrying homozygous wild‐type alleles (WW). Kaplan–Meier analyses showed a significantly longer median survival time in patients with WV + VV genotypes of SNP rs2640908 than those with WW genotype (11.6 months vs. 8.1 months; log rank P = 0.030). In addition, we also observed a significant difference on the genotype distribution of SNP rs2640908 in patients with and without portal vein thrombus (P = 0.041).
Conclusions
Our study provides the first evidence that a single functional polymorphism of
PER3 gene is significantly associated with overall survival in HCC patients treated with TACE. |
| doi_str_mv | 10.1111/j.1478-3231.2012.02849.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1093443918</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1037887367</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3369-d166b90354705f7d62f5c9d06e76df2b41890b5d3e419da674a69ed0f0900e233</originalsourceid><addsrcrecordid>eNqNkU9v1DAQxS0EoqXlKyAfe0kY24kdHzhUpf_ECmihhdvIGztdb5M4jRN199uTsGXP-DIjvd_zjOYRQhmkbHof1ynLVJEILljKgfEUeJHpdPOKHO6F1_ueiwPyLsY1ANM6Z2_JAecFaMbhkOAprca2HHxoTU27UG-b0HcrHxvqW_r9_FbQB9c66iM1MYbSm8FZ-uyHFe368NCGOCkTuXKdGULp6nqsTU9L05e-DY05Jm8qU0f3_qUekbuL859nV8ni2-X12eki8UJInVgm5VKDyDMFeaWs5FVeagvSKWkrvsxYoWGZW-Eypq2RKjNSOwsVaADHhTgiJ7t_p62eRhcHbHyc1zGtC2NEBlpkmdCs-A9UqKJQQqoJ_fCCjsvGWex635h-i__uNwGfdsCzr912rzPAOSdc4xwBznHgnBP-zQk3uLi-n7vJn-z8Pg5us_eb_hGn8SrHX18v8eb3l5vPXOf4Q_wB6JeUig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1037887367</pqid></control><display><type>article</type><title>A functional polymorphism in PER3 gene is associated with prognosis in hepatocellular carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zhao, Binyu ; Lu, Jianguo ; Yin, Jikai ; Liu, Hanqiang ; Guo, Xu ; Yang, Yefa ; Ge, Naijian ; Zhu, Yong ; Zhang, Hongxin ; Xing, Jinliang</creator><creatorcontrib>Zhao, Binyu ; Lu, Jianguo ; Yin, Jikai ; Liu, Hanqiang ; Guo, Xu ; Yang, Yefa ; Ge, Naijian ; Zhu, Yong ; Zhang, Hongxin ; Xing, Jinliang</creatorcontrib><description>Background
Previous studies have revealed that circadian genes play important roles in cell proliferation, apoptosis, cell cycle control, DNA damage response and treatment response of chemotherapy agents in cancers.
Aims
We hypothesized that the polymorphisms in circadian genes may be associated with prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE).
Methods
Twelve functional single nucleotide polymorphisms (SNPs) in circadian negative feedback regulation genes (including
CRY1, CRY2, PER1, PER2 and
PER3) were genotyped using Sequenom iPLEX genotyping method in 337 HCC patients treated with TACE and analysed for associations with overall survival.
Results
Our data showed that one SNP rs2640908 in
PER3 gene was significantly associated with overall survival of HCC patients (P = 0.027). Patients carrying at least one variant allele of rs2640908 (WV + VV) had a significantly decreased risk of death (hazard ratio, 0.71; 95% confidence interval, 0.53–0.90), when compared with those carrying homozygous wild‐type alleles (WW). Kaplan–Meier analyses showed a significantly longer median survival time in patients with WV + VV genotypes of SNP rs2640908 than those with WW genotype (11.6 months vs. 8.1 months; log rank P = 0.030). In addition, we also observed a significant difference on the genotype distribution of SNP rs2640908 in patients with and without portal vein thrombus (P = 0.041).
Conclusions
Our study provides the first evidence that a single functional polymorphism of
PER3 gene is significantly associated with overall survival in HCC patients treated with TACE.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/j.1478-3231.2012.02849.x</identifier><identifier>PMID: 22809120</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Apoptosis ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - therapy ; Cell cycle ; Cell proliferation ; Chemoembolization, Therapeutic ; Chemotherapy ; China - epidemiology ; circadian gene ; Circadian Rhythm - genetics ; Circadian rhythms ; Data processing ; DNA damage ; Feedback ; Female ; Gene polymorphism ; Gene regulation ; Genetic Predisposition to Disease ; Genotype ; Genotyping ; Hepatocellular carcinoma ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms - diagnosis ; Liver Neoplasms - genetics ; Liver Neoplasms - mortality ; Liver Neoplasms - therapy ; Male ; Middle Aged ; Period 1 protein ; Period 2 protein ; Period 3 protein ; Period Circadian Proteins - genetics ; Polymorphism, Single Nucleotide ; Prognosis ; Single-nucleotide polymorphism ; Survival ; Survival Rate ; Transcription ; Young Adult</subject><ispartof>Liver international, 2012-10, Vol.32 (9), p.1451-1459</ispartof><rights>2012 John Wiley & Sons A/S</rights><rights>2012 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1478-3231.2012.02849.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1478-3231.2012.02849.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22809120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Binyu</creatorcontrib><creatorcontrib>Lu, Jianguo</creatorcontrib><creatorcontrib>Yin, Jikai</creatorcontrib><creatorcontrib>Liu, Hanqiang</creatorcontrib><creatorcontrib>Guo, Xu</creatorcontrib><creatorcontrib>Yang, Yefa</creatorcontrib><creatorcontrib>Ge, Naijian</creatorcontrib><creatorcontrib>Zhu, Yong</creatorcontrib><creatorcontrib>Zhang, Hongxin</creatorcontrib><creatorcontrib>Xing, Jinliang</creatorcontrib><title>A functional polymorphism in PER3 gene is associated with prognosis in hepatocellular carcinoma</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background
Previous studies have revealed that circadian genes play important roles in cell proliferation, apoptosis, cell cycle control, DNA damage response and treatment response of chemotherapy agents in cancers.
Aims
We hypothesized that the polymorphisms in circadian genes may be associated with prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE).
Methods
Twelve functional single nucleotide polymorphisms (SNPs) in circadian negative feedback regulation genes (including
CRY1, CRY2, PER1, PER2 and
PER3) were genotyped using Sequenom iPLEX genotyping method in 337 HCC patients treated with TACE and analysed for associations with overall survival.
Results
Our data showed that one SNP rs2640908 in
PER3 gene was significantly associated with overall survival of HCC patients (P = 0.027). Patients carrying at least one variant allele of rs2640908 (WV + VV) had a significantly decreased risk of death (hazard ratio, 0.71; 95% confidence interval, 0.53–0.90), when compared with those carrying homozygous wild‐type alleles (WW). Kaplan–Meier analyses showed a significantly longer median survival time in patients with WV + VV genotypes of SNP rs2640908 than those with WW genotype (11.6 months vs. 8.1 months; log rank P = 0.030). In addition, we also observed a significant difference on the genotype distribution of SNP rs2640908 in patients with and without portal vein thrombus (P = 0.041).
Conclusions
Our study provides the first evidence that a single functional polymorphism of
PER3 gene is significantly associated with overall survival in HCC patients treated with TACE.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Cell cycle</subject><subject>Cell proliferation</subject><subject>Chemoembolization, Therapeutic</subject><subject>Chemotherapy</subject><subject>China - epidemiology</subject><subject>circadian gene</subject><subject>Circadian Rhythm - genetics</subject><subject>Circadian rhythms</subject><subject>Data processing</subject><subject>DNA damage</subject><subject>Feedback</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Gene regulation</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Period 1 protein</subject><subject>Period 2 protein</subject><subject>Period 3 protein</subject><subject>Period Circadian Proteins - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prognosis</subject><subject>Single-nucleotide polymorphism</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Transcription</subject><subject>Young Adult</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EoqXlKyAfe0kY24kdHzhUpf_ECmihhdvIGztdb5M4jRN199uTsGXP-DIjvd_zjOYRQhmkbHof1ynLVJEILljKgfEUeJHpdPOKHO6F1_ueiwPyLsY1ANM6Z2_JAecFaMbhkOAprca2HHxoTU27UG-b0HcrHxvqW_r9_FbQB9c66iM1MYbSm8FZ-uyHFe368NCGOCkTuXKdGULp6nqsTU9L05e-DY05Jm8qU0f3_qUekbuL859nV8ni2-X12eki8UJInVgm5VKDyDMFeaWs5FVeagvSKWkrvsxYoWGZW-Eypq2RKjNSOwsVaADHhTgiJ7t_p62eRhcHbHyc1zGtC2NEBlpkmdCs-A9UqKJQQqoJ_fCCjsvGWex635h-i__uNwGfdsCzr912rzPAOSdc4xwBznHgnBP-zQk3uLi-n7vJn-z8Pg5us_eb_hGn8SrHX18v8eb3l5vPXOf4Q_wB6JeUig</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Zhao, Binyu</creator><creator>Lu, Jianguo</creator><creator>Yin, Jikai</creator><creator>Liu, Hanqiang</creator><creator>Guo, Xu</creator><creator>Yang, Yefa</creator><creator>Ge, Naijian</creator><creator>Zhu, Yong</creator><creator>Zhang, Hongxin</creator><creator>Xing, Jinliang</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201210</creationdate><title>A functional polymorphism in PER3 gene is associated with prognosis in hepatocellular carcinoma</title><author>Zhao, Binyu ; Lu, Jianguo ; Yin, Jikai ; Liu, Hanqiang ; Guo, Xu ; Yang, Yefa ; Ge, Naijian ; Zhu, Yong ; Zhang, Hongxin ; Xing, Jinliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3369-d166b90354705f7d62f5c9d06e76df2b41890b5d3e419da674a69ed0f0900e233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>Cell cycle</topic><topic>Cell proliferation</topic><topic>Chemoembolization, Therapeutic</topic><topic>Chemotherapy</topic><topic>China - epidemiology</topic><topic>circadian gene</topic><topic>Circadian Rhythm - genetics</topic><topic>Circadian rhythms</topic><topic>Data processing</topic><topic>DNA damage</topic><topic>Feedback</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Gene regulation</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotyping</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Period 1 protein</topic><topic>Period 2 protein</topic><topic>Period 3 protein</topic><topic>Period Circadian Proteins - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prognosis</topic><topic>Single-nucleotide polymorphism</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Transcription</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Binyu</creatorcontrib><creatorcontrib>Lu, Jianguo</creatorcontrib><creatorcontrib>Yin, Jikai</creatorcontrib><creatorcontrib>Liu, Hanqiang</creatorcontrib><creatorcontrib>Guo, Xu</creatorcontrib><creatorcontrib>Yang, Yefa</creatorcontrib><creatorcontrib>Ge, Naijian</creatorcontrib><creatorcontrib>Zhu, Yong</creatorcontrib><creatorcontrib>Zhang, Hongxin</creatorcontrib><creatorcontrib>Xing, Jinliang</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Binyu</au><au>Lu, Jianguo</au><au>Yin, Jikai</au><au>Liu, Hanqiang</au><au>Guo, Xu</au><au>Yang, Yefa</au><au>Ge, Naijian</au><au>Zhu, Yong</au><au>Zhang, Hongxin</au><au>Xing, Jinliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A functional polymorphism in PER3 gene is associated with prognosis in hepatocellular carcinoma</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2012-10</date><risdate>2012</risdate><volume>32</volume><issue>9</issue><spage>1451</spage><epage>1459</epage><pages>1451-1459</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background
Previous studies have revealed that circadian genes play important roles in cell proliferation, apoptosis, cell cycle control, DNA damage response and treatment response of chemotherapy agents in cancers.
Aims
We hypothesized that the polymorphisms in circadian genes may be associated with prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE).
Methods
Twelve functional single nucleotide polymorphisms (SNPs) in circadian negative feedback regulation genes (including
CRY1, CRY2, PER1, PER2 and
PER3) were genotyped using Sequenom iPLEX genotyping method in 337 HCC patients treated with TACE and analysed for associations with overall survival.
Results
Our data showed that one SNP rs2640908 in
PER3 gene was significantly associated with overall survival of HCC patients (P = 0.027). Patients carrying at least one variant allele of rs2640908 (WV + VV) had a significantly decreased risk of death (hazard ratio, 0.71; 95% confidence interval, 0.53–0.90), when compared with those carrying homozygous wild‐type alleles (WW). Kaplan–Meier analyses showed a significantly longer median survival time in patients with WV + VV genotypes of SNP rs2640908 than those with WW genotype (11.6 months vs. 8.1 months; log rank P = 0.030). In addition, we also observed a significant difference on the genotype distribution of SNP rs2640908 in patients with and without portal vein thrombus (P = 0.041).
Conclusions
Our study provides the first evidence that a single functional polymorphism of
PER3 gene is significantly associated with overall survival in HCC patients treated with TACE.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>22809120</pmid><doi>10.1111/j.1478-3231.2012.02849.x</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Apoptosis Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - therapy Cell cycle Cell proliferation Chemoembolization, Therapeutic Chemotherapy China - epidemiology circadian gene Circadian Rhythm - genetics Circadian rhythms Data processing DNA damage Feedback Female Gene polymorphism Gene regulation Genetic Predisposition to Disease Genotype Genotyping Hepatocellular carcinoma Humans Kaplan-Meier Estimate Liver Neoplasms - diagnosis Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - therapy Male Middle Aged Period 1 protein Period 2 protein Period 3 protein Period Circadian Proteins - genetics Polymorphism, Single Nucleotide Prognosis Single-nucleotide polymorphism Survival Survival Rate Transcription Young Adult |
| title | A functional polymorphism in PER3 gene is associated with prognosis in hepatocellular carcinoma |
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