Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes

Aims/hypothesis Obesity and insulin resistance are associated with low-grade chronic inflammation. Glucagon-like peptide-1 (GLP-1) is known to reduce insulin resistance. We investigated whether GLP-1 has anti-inflammatory effects on adipose tissue, including adipocytes and adipose tissue macrophages...

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Veröffentlicht in:	Diabetologia 2012-09, Vol.55 (9), p.2456-2468
Hauptverfasser:	Lee, Y.-S., Park, M.-S., Choung, J.-S., Kim, S.-S., Oh, H.-H., Choi, C.-S., Ha, S.-Y., Kang, Y., Kim, Y., Jun, H.-S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Adenoviruses Adipocytes Adipose Tissue - metabolism Animals Anti-Inflammatory Agents - pharmacology Biological and medical sciences Body fat Body Fat Distribution Cytokines Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Gene Expression Regulation Glucagon Glucagon-Like Peptide 1 - metabolism Glucagon-Like Peptide 1 - pharmacology Glucagon-Like Peptide-1 Receptor Glucose Human Physiology Hypotheses Inflammation Inflammation - drug therapy Inflammation - metabolism Insulin Resistance Internal Medicine Kinases Macrophages - drug effects Macrophages - metabolism Medical research Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice Mice, Obese NF-kappa B - metabolism Obesity Obesity - metabolism Peptides Proteins Real-Time Polymerase Chain Reaction Receptors, Glucagon - metabolism
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