Systemic Leptin Administration in Supraphysiological Doses Maintains Bone Mineral Density and Mechanical Strength Despite Significant Weight Loss

The effects of leptin on bone are controversial. Although in vitro studies have shown that leptin stimulates osteoblast differentiation and mineralization and inhibits osteoclastogenesis, some rodent studies have shown that leptin administered centrally might result in decreased bone formation. In t...

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